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Gene: CCDC66 |
Gene summary for CCDC66 |
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Gene information | Species | Human | Gene symbol | CCDC66 | Gene ID | 285331 |
Gene name | coiled-coil domain containing 66 | |
Gene Alias | CCDC66 | |
Cytomap | 3p14.3 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | A2RUB6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
285331 | CCDC66 | C21 | Human | Oral cavity | OSCC | 6.61e-07 | 2.34e-01 | 0.2678 |
285331 | CCDC66 | C38 | Human | Oral cavity | OSCC | 9.68e-04 | 5.88e-01 | 0.172 |
285331 | CCDC66 | C43 | Human | Oral cavity | OSCC | 1.66e-04 | 1.65e-01 | 0.1704 |
285331 | CCDC66 | C46 | Human | Oral cavity | OSCC | 4.83e-37 | 8.40e-01 | 0.1673 |
285331 | CCDC66 | C08 | Human | Oral cavity | OSCC | 1.55e-02 | 1.85e-01 | 0.1919 |
285331 | CCDC66 | C09 | Human | Oral cavity | OSCC | 3.24e-06 | 2.39e-01 | 0.1431 |
285331 | CCDC66 | LN46 | Human | Oral cavity | OSCC | 6.78e-14 | 7.29e-01 | 0.1666 |
285331 | CCDC66 | SYSMH2 | Human | Oral cavity | OSCC | 1.51e-06 | 2.33e-01 | 0.2326 |
285331 | CCDC66 | SYSMH3 | Human | Oral cavity | OSCC | 1.70e-13 | 4.82e-01 | 0.2442 |
285331 | CCDC66 | SYSMH6 | Human | Oral cavity | OSCC | 2.19e-05 | 2.12e-01 | 0.1275 |
285331 | CCDC66 | male-WTA | Human | Thyroid | PTC | 1.21e-11 | 1.21e-01 | 0.1037 |
285331 | CCDC66 | PTC01 | Human | Thyroid | PTC | 3.12e-16 | 2.70e-01 | 0.1899 |
285331 | CCDC66 | PTC03 | Human | Thyroid | PTC | 5.39e-12 | 3.61e-01 | 0.1784 |
285331 | CCDC66 | PTC04 | Human | Thyroid | PTC | 4.38e-21 | 3.17e-01 | 0.1927 |
285331 | CCDC66 | PTC05 | Human | Thyroid | PTC | 7.84e-19 | 6.51e-01 | 0.2065 |
285331 | CCDC66 | PTC06 | Human | Thyroid | PTC | 7.68e-29 | 5.42e-01 | 0.2057 |
285331 | CCDC66 | PTC07 | Human | Thyroid | PTC | 5.85e-33 | 5.83e-01 | 0.2044 |
285331 | CCDC66 | ATC09 | Human | Thyroid | ATC | 4.80e-06 | 2.64e-01 | 0.2871 |
285331 | CCDC66 | ATC12 | Human | Thyroid | ATC | 1.47e-18 | 3.99e-01 | 0.34 |
285331 | CCDC66 | ATC13 | Human | Thyroid | ATC | 3.91e-41 | 7.35e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000931416 | Oral cavity | OSCC | response to radiation | 241/7305 | 456/18723 | 9.76e-10 | 2.40e-08 | 241 |
GO:00094164 | Oral cavity | OSCC | response to light stimulus | 159/7305 | 320/18723 | 5.98e-05 | 4.92e-04 | 159 |
GO:0009314111 | Thyroid | PTC | response to radiation | 195/5968 | 456/18723 | 5.10e-07 | 8.27e-06 | 195 |
GO:00094167 | Thyroid | PTC | response to light stimulus | 127/5968 | 320/18723 | 1.76e-03 | 9.58e-03 | 127 |
GO:000931426 | Thyroid | ATC | response to radiation | 210/6293 | 456/18723 | 1.69e-08 | 3.39e-07 | 210 |
GO:000941613 | Thyroid | ATC | response to light stimulus | 139/6293 | 320/18723 | 1.42e-04 | 9.88e-04 | 139 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC66 | SNV | Missense_Mutation | novel | c.926N>G | p.Asp309Gly | p.D309G | A2RUB6 | protein_coding | tolerated(0.05) | benign(0.024) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CCDC66 | SNV | Missense_Mutation | novel | c.1687N>C | p.Ser563Pro | p.S563P | A2RUB6 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CCDC66 | SNV | Missense_Mutation | rs774817360 | c.1613G>A | p.Arg538Gln | p.R538Q | A2RUB6 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCDC66 | SNV | Missense_Mutation | c.746C>A | p.Thr249Asn | p.T249N | A2RUB6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CCDC66 | SNV | Missense_Mutation | c.2154N>T | p.Lys718Asn | p.K718N | A2RUB6 | protein_coding | deleterious(0) | probably_damaging(0.913) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CCDC66 | SNV | Missense_Mutation | novel | c.149N>A | p.Thr50Asn | p.T50N | A2RUB6 | protein_coding | tolerated(0.08) | benign(0.013) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CCDC66 | deletion | Frame_Shift_Del | c.194delN | p.Lys66AsnfsTer22 | p.K66Nfs*22 | A2RUB6 | protein_coding | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
CCDC66 | insertion | Frame_Shift_Ins | novel | c.612_613insA | p.Thr207AsnfsTer2 | p.T207Nfs*2 | A2RUB6 | protein_coding | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CCDC66 | insertion | Frame_Shift_Ins | novel | c.612_613insA | p.Thr207AsnfsTer2 | p.T207Nfs*2 | A2RUB6 | protein_coding | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
CCDC66 | insertion | Frame_Shift_Ins | rs753303042 | c.2450_2451insA | p.Asn819LysfsTer3 | p.N819Kfs*3 | A2RUB6 | protein_coding | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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