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Gene: CCDC190 |
Gene summary for CCDC190 |
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Gene information | Species | Human | Gene symbol | CCDC190 | Gene ID | 339512 |
Gene name | coiled-coil domain containing 190 | |
Gene Alias | C1orf110 | |
Cytomap | 1q23.3 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q86UF4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
339512 | CCDC190 | CCI_1 | Human | Cervix | CC | 2.30e-07 | 5.00e-01 | 0.528 |
339512 | CCDC190 | CCI_2 | Human | Cervix | CC | 2.86e-05 | 3.35e-01 | 0.5249 |
339512 | CCDC190 | LZE2D | Human | Esophagus | HGIN | 6.44e-06 | 5.85e-01 | 0.0642 |
339512 | CCDC190 | LZE2T | Human | Esophagus | ESCC | 1.80e-11 | 1.00e+00 | 0.082 |
339512 | CCDC190 | LZE7T | Human | Esophagus | ESCC | 2.07e-09 | 6.19e-01 | 0.0667 |
339512 | CCDC190 | LZE8T | Human | Esophagus | ESCC | 9.33e-11 | 3.37e-01 | 0.067 |
339512 | CCDC190 | LZE20T | Human | Esophagus | ESCC | 1.30e-10 | 4.18e-01 | 0.0662 |
339512 | CCDC190 | LZE21D1 | Human | Esophagus | HGIN | 4.41e-04 | 4.25e-01 | 0.0632 |
339512 | CCDC190 | LZE22D1 | Human | Esophagus | HGIN | 3.52e-12 | 7.02e-01 | 0.0595 |
339512 | CCDC190 | LZE22T | Human | Esophagus | ESCC | 6.95e-12 | 8.56e-01 | 0.068 |
339512 | CCDC190 | LZE24T | Human | Esophagus | ESCC | 3.10e-46 | 1.39e+00 | 0.0596 |
339512 | CCDC190 | LZE21T | Human | Esophagus | ESCC | 2.27e-11 | 6.39e-01 | 0.0655 |
339512 | CCDC190 | P1T-E | Human | Esophagus | ESCC | 3.58e-07 | 2.95e-01 | 0.0875 |
339512 | CCDC190 | P4T-E | Human | Esophagus | ESCC | 2.81e-13 | 3.34e-01 | 0.1323 |
339512 | CCDC190 | P9T-E | Human | Esophagus | ESCC | 4.09e-44 | 1.07e+00 | 0.1131 |
339512 | CCDC190 | P15T-E | Human | Esophagus | ESCC | 1.05e-10 | 3.26e-01 | 0.1149 |
339512 | CCDC190 | P20T-E | Human | Esophagus | ESCC | 2.54e-64 | 1.40e+00 | 0.1124 |
339512 | CCDC190 | P22T-E | Human | Esophagus | ESCC | 6.62e-20 | 3.89e-01 | 0.1236 |
339512 | CCDC190 | P23T-E | Human | Esophagus | ESCC | 3.47e-64 | 1.70e+00 | 0.108 |
339512 | CCDC190 | P27T-E | Human | Esophagus | ESCC | 1.13e-16 | 3.35e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC190 | SNV | Missense_Mutation | novel | c.259N>A | p.Val87Met | p.V87M | Q86UF4 | protein_coding | tolerated(0.51) | benign(0) | TCGA-EY-A2OO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
CCDC190 | SNV | Missense_Mutation | novel | c.469G>T | p.Ala157Ser | p.A157S | Q86UF4 | protein_coding | deleterious(0.04) | possibly_damaging(0.578) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
CCDC190 | insertion | Frame_Shift_Ins | novel | c.499_500insTT | p.Lys167IlefsTer4 | p.K167Ifs*4 | Q86UF4 | protein_coding | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
CCDC190 | insertion | Frame_Shift_Ins | novel | c.498_499insTCTTTAGACCTTTCAACTT | p.Lys167SerfsTer7 | p.K167Sfs*7 | Q86UF4 | protein_coding | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
CCDC190 | insertion | In_Frame_Ins | novel | c.404_405insCTTAGAACACACAGACACACACAGGGA | p.Lys135delinsAsnLeuGluHisThrAspThrHisArgGlu | p.K135delinsNLEHTDTHRE | Q86UF4 | protein_coding | TCGA-B5-A11F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD | ||
CCDC190 | insertion | Frame_Shift_Ins | novel | c.499_500insTT | p.Lys167IlefsTer4 | p.K167Ifs*4 | Q86UF4 | protein_coding | TCGA-B5-A11I-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | PD | ||
CCDC190 | insertion | Frame_Shift_Ins | novel | c.498_499insTCTTTAGACCTTTCAACTT | p.Lys167SerfsTer7 | p.K167Sfs*7 | Q86UF4 | protein_coding | TCGA-B5-A11I-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | PD | ||
CCDC190 | insertion | Frame_Shift_Ins | novel | c.542_543insA | p.Asn181LysfsTer14 | p.N181Kfs*14 | Q86UF4 | protein_coding | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
CCDC190 | SNV | Missense_Mutation | c.658G>T | p.Gly220Trp | p.G220W | Q86UF4 | protein_coding | tolerated(0.19) | benign(0.005) | TCGA-FV-A4ZP-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
CCDC190 | SNV | Missense_Mutation | c.124C>A | p.His42Asn | p.H42N | Q86UF4 | protein_coding | tolerated(0.07) | possibly_damaging(0.602) | TCGA-44-3917-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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