![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CCDC138 |
Gene summary for CCDC138 |
![]() |
Gene information | Species | Human | Gene symbol | CCDC138 | Gene ID | 165055 |
Gene name | coiled-coil domain containing 138 | |
Gene Alias | CCDC138 | |
Cytomap | 2q13 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q96M89 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
165055 | CCDC138 | CCI_2 | Human | Cervix | CC | 4.31e-03 | 5.96e-01 | 0.5249 |
165055 | CCDC138 | CCI_3 | Human | Cervix | CC | 1.12e-12 | 7.98e-01 | 0.516 |
165055 | CCDC138 | A015-C-203 | Human | Colorectum | FAP | 3.29e-05 | -1.59e-01 | -0.1294 |
165055 | CCDC138 | A002-C-205 | Human | Colorectum | FAP | 2.91e-03 | -1.81e-01 | -0.1236 |
165055 | CCDC138 | A015-C-104 | Human | Colorectum | FAP | 1.21e-05 | -1.28e-01 | -0.1899 |
165055 | CCDC138 | A002-C-016 | Human | Colorectum | FAP | 2.04e-03 | -1.55e-01 | 0.0521 |
165055 | CCDC138 | A002-C-116 | Human | Colorectum | FAP | 4.04e-06 | -2.02e-01 | -0.0452 |
165055 | CCDC138 | A018-E-020 | Human | Colorectum | FAP | 2.51e-02 | -1.57e-01 | -0.2034 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC138 | SNV | Missense_Mutation | novel | c.491N>A | p.Ser164Tyr | p.S164Y | Q96M89 | protein_coding | deleterious(0.01) | possibly_damaging(0.874) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC138 | SNV | Missense_Mutation | rs777265536 | c.943N>A | p.Glu315Lys | p.E315K | Q96M89 | protein_coding | deleterious(0) | benign(0.187) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
CCDC138 | SNV | Missense_Mutation | c.1788N>G | p.Ile596Met | p.I596M | Q96M89 | protein_coding | deleterious(0.04) | possibly_damaging(0.847) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CCDC138 | SNV | Missense_Mutation | novel | c.1243N>A | p.Pro415Thr | p.P415T | Q96M89 | protein_coding | deleterious(0) | probably_damaging(0.916) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
CCDC138 | SNV | Missense_Mutation | novel | c.772C>A | p.Leu258Ile | p.L258I | Q96M89 | protein_coding | deleterious(0.04) | possibly_damaging(0.556) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
CCDC138 | SNV | Missense_Mutation | rs778719186 | c.431N>A | p.Arg144Gln | p.R144Q | Q96M89 | protein_coding | tolerated_low_confidence(0.35) | benign(0) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC138 | SNV | Missense_Mutation | c.1695N>T | p.Lys565Asn | p.K565N | Q96M89 | protein_coding | tolerated(0.45) | benign(0.003) | TCGA-BS-A0UA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CCDC138 | SNV | Missense_Mutation | c.1406N>A | p.Ser469Tyr | p.S469Y | Q96M89 | protein_coding | deleterious(0.02) | benign(0.325) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CCDC138 | SNV | Missense_Mutation | c.962N>T | p.Arg321Ile | p.R321I | Q96M89 | protein_coding | deleterious(0) | benign(0.141) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CCDC138 | SNV | Missense_Mutation | c.1866N>G | p.Ile622Met | p.I622M | Q96M89 | protein_coding | deleterious(0) | possibly_damaging(0.907) | TCGA-D1-A16Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |