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Gene: CBX2 |
Gene summary for CBX2 |
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Gene information | Species | Human | Gene symbol | CBX2 | Gene ID | 84733 |
Gene name | chromobox 2 | |
Gene Alias | CDCA6 | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q14781 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84733 | CBX2 | LZE22T | Human | Esophagus | ESCC | 1.57e-02 | 2.52e-01 | 0.068 |
84733 | CBX2 | LZE21T | Human | Esophagus | ESCC | 6.52e-03 | 2.77e-01 | 0.0655 |
84733 | CBX2 | P2T-E | Human | Esophagus | ESCC | 1.47e-14 | 2.62e-01 | 0.1177 |
84733 | CBX2 | P4T-E | Human | Esophagus | ESCC | 1.75e-05 | 1.63e-01 | 0.1323 |
84733 | CBX2 | P9T-E | Human | Esophagus | ESCC | 1.45e-04 | 1.56e-01 | 0.1131 |
84733 | CBX2 | P10T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.49e-01 | 0.116 |
84733 | CBX2 | P11T-E | Human | Esophagus | ESCC | 2.06e-07 | 2.80e-01 | 0.1426 |
84733 | CBX2 | P12T-E | Human | Esophagus | ESCC | 4.40e-09 | 1.86e-01 | 0.1122 |
84733 | CBX2 | P15T-E | Human | Esophagus | ESCC | 5.83e-12 | 3.21e-01 | 0.1149 |
84733 | CBX2 | P16T-E | Human | Esophagus | ESCC | 8.56e-12 | 2.56e-01 | 0.1153 |
84733 | CBX2 | P21T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.01e-01 | 0.1617 |
84733 | CBX2 | P22T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.57e-01 | 0.1236 |
84733 | CBX2 | P26T-E | Human | Esophagus | ESCC | 2.86e-20 | 3.52e-01 | 0.1276 |
84733 | CBX2 | P27T-E | Human | Esophagus | ESCC | 3.50e-02 | 9.73e-02 | 0.1055 |
84733 | CBX2 | P28T-E | Human | Esophagus | ESCC | 3.02e-26 | 4.74e-01 | 0.1149 |
84733 | CBX2 | P30T-E | Human | Esophagus | ESCC | 1.56e-18 | 6.21e-01 | 0.137 |
84733 | CBX2 | P31T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.56e-01 | 0.1251 |
84733 | CBX2 | P32T-E | Human | Esophagus | ESCC | 3.60e-13 | 2.65e-01 | 0.1666 |
84733 | CBX2 | P37T-E | Human | Esophagus | ESCC | 7.83e-07 | 1.64e-01 | 0.1371 |
84733 | CBX2 | P40T-E | Human | Esophagus | ESCC | 3.18e-05 | 1.72e-01 | 0.109 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:000632511 | Liver | HCC | chromatin organization | 206/7958 | 409/18723 | 7.23e-04 | 4.41e-03 | 206 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CBX2 | SNV | Missense_Mutation | c.1474N>T | p.Asp492Tyr | p.D492Y | Q14781 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-97-7554-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | alimta | SD | |
CBX2 | SNV | Missense_Mutation | c.1517N>T | p.Thr506Ile | p.T506I | Q14781 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-MP-A4TK-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
CBX2 | SNV | Missense_Mutation | novel | c.670G>T | p.Gly224Cys | p.G224C | Q14781 | protein_coding | deleterious(0.02) | possibly_damaging(0.848) | TCGA-NJ-A4YG-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CBX2 | SNV | Missense_Mutation | rs375170872 | c.271C>T | p.Arg91Trp | p.R91W | Q14781 | protein_coding | deleterious(0.03) | benign(0.059) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CBX2 | SNV | Missense_Mutation | novel | c.1165N>T | p.Gly389Trp | p.G389W | Q14781 | protein_coding | deleterious(0.03) | possibly_damaging(0.887) | TCGA-39-5016-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CBX2 | SNV | Missense_Mutation | novel | c.658N>A | p.Glu220Lys | p.E220K | Q14781 | protein_coding | tolerated(0.27) | possibly_damaging(0.475) | TCGA-43-6773-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CBX2 | SNV | Missense_Mutation | novel | c.1284G>T | p.Arg428Ser | p.R428S | Q14781 | protein_coding | deleterious(0.02) | benign(0.401) | TCGA-66-2787-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CBX2 | SNV | Missense_Mutation | novel | c.1565C>G | p.Thr522Ser | p.T522S | Q14781 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-77-A5G6-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
CBX2 | SNV | Missense_Mutation | rs139509934 | c.481N>T | p.Arg161Trp | p.R161W | Q14781 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-NC-A5HI-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
CBX2 | SNV | Missense_Mutation | rs781926428 | c.1522G>A | p.Val508Ile | p.V508I | Q14781 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-BA-A6DJ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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