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Gene: CAMLG |
Gene summary for CAMLG |
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Gene information | Species | Human | Gene symbol | CAMLG | Gene ID | 819 |
Gene name | calcium modulating ligand | |
Gene Alias | CAML | |
Cytomap | 5q31.1 | |
Gene Type | protein-coding | GO ID | GO:0001776 | UniProtAcc | P49069 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
819 | CAMLG | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.11e-03 | 3.08e-01 | -0.0811 |
819 | CAMLG | HTA11_347_2000001011 | Human | Colorectum | AD | 2.12e-05 | 2.73e-01 | -0.1954 |
819 | CAMLG | HTA11_866_3004761011 | Human | Colorectum | AD | 9.47e-07 | 3.17e-01 | 0.096 |
819 | CAMLG | HTA11_7663_2000001011 | Human | Colorectum | SER | 4.88e-02 | 3.70e-01 | 0.0131 |
819 | CAMLG | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.86e-10 | 3.03e-01 | 0.0674 |
819 | CAMLG | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.95e-10 | 4.06e-01 | 0.294 |
819 | CAMLG | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 3.75e-03 | 5.49e-01 | 0.3487 |
819 | CAMLG | HTA11_99999965104_69814 | Human | Colorectum | MSS | 8.63e-04 | 3.45e-01 | 0.281 |
819 | CAMLG | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.24e-24 | 7.55e-01 | 0.3859 |
819 | CAMLG | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.75e-07 | 2.88e-01 | 0.3005 |
819 | CAMLG | AEH-subject1 | Human | Endometrium | AEH | 3.98e-10 | -3.98e-01 | -0.3059 |
819 | CAMLG | AEH-subject2 | Human | Endometrium | AEH | 4.03e-14 | -4.24e-01 | -0.2525 |
819 | CAMLG | AEH-subject3 | Human | Endometrium | AEH | 1.20e-25 | -5.16e-01 | -0.2576 |
819 | CAMLG | AEH-subject4 | Human | Endometrium | AEH | 5.25e-09 | -3.56e-01 | -0.2657 |
819 | CAMLG | AEH-subject5 | Human | Endometrium | AEH | 5.04e-12 | -4.49e-01 | -0.2953 |
819 | CAMLG | EEC-subject1 | Human | Endometrium | EEC | 2.02e-13 | -3.96e-01 | -0.2682 |
819 | CAMLG | EEC-subject2 | Human | Endometrium | EEC | 6.00e-22 | -5.23e-01 | -0.2607 |
819 | CAMLG | EEC-subject3 | Human | Endometrium | EEC | 5.48e-37 | -4.30e-01 | -0.2525 |
819 | CAMLG | EEC-subject4 | Human | Endometrium | EEC | 8.96e-07 | -3.58e-01 | -0.2571 |
819 | CAMLG | EEC-subject5 | Human | Endometrium | EEC | 1.27e-09 | -3.54e-01 | -0.249 |
Page: 1 2 3 4 5 6 7 8 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0042176 | Colorectum | AD | regulation of protein catabolic process | 160/3918 | 391/18723 | 1.06e-19 | 7.34e-17 | 160 |
GO:1903362 | Colorectum | AD | regulation of cellular protein catabolic process | 109/3918 | 255/18723 | 2.14e-15 | 6.08e-13 | 109 |
GO:0010498 | Colorectum | AD | proteasomal protein catabolic process | 174/3918 | 490/18723 | 3.18e-14 | 7.66e-12 | 174 |
GO:0009895 | Colorectum | AD | negative regulation of catabolic process | 124/3918 | 320/18723 | 1.66e-13 | 3.35e-11 | 124 |
GO:1903050 | Colorectum | AD | regulation of proteolysis involved in cellular protein catabolic process | 92/3918 | 221/18723 | 2.04e-12 | 3.19e-10 | 92 |
GO:0031330 | Colorectum | AD | negative regulation of cellular catabolic process | 104/3918 | 262/18723 | 2.66e-12 | 3.96e-10 | 104 |
GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
GO:0043161 | Colorectum | AD | proteasome-mediated ubiquitin-dependent protein catabolic process | 141/3918 | 412/18723 | 1.77e-10 | 1.68e-08 | 141 |
GO:0031647 | Colorectum | AD | regulation of protein stability | 108/3918 | 298/18723 | 6.33e-10 | 5.08e-08 | 108 |
GO:0042177 | Colorectum | AD | negative regulation of protein catabolic process | 55/3918 | 121/18723 | 1.19e-09 | 8.85e-08 | 55 |
GO:0061136 | Colorectum | AD | regulation of proteasomal protein catabolic process | 75/3918 | 187/18723 | 1.65e-09 | 1.20e-07 | 75 |
GO:2000058 | Colorectum | AD | regulation of ubiquitin-dependent protein catabolic process | 68/3918 | 164/18723 | 1.82e-09 | 1.31e-07 | 68 |
GO:1903363 | Colorectum | AD | negative regulation of cellular protein catabolic process | 39/3918 | 75/18723 | 2.69e-09 | 1.87e-07 | 39 |
GO:0050821 | Colorectum | AD | protein stabilization | 73/3918 | 191/18723 | 3.02e-08 | 1.64e-06 | 73 |
GO:1903320 | Colorectum | AD | regulation of protein modification by small protein conjugation or removal | 86/3918 | 242/18723 | 9.43e-08 | 4.65e-06 | 86 |
GO:0032434 | Colorectum | AD | regulation of proteasomal ubiquitin-dependent protein catabolic process | 54/3918 | 134/18723 | 2.51e-07 | 1.02e-05 | 54 |
GO:1903051 | Colorectum | AD | negative regulation of proteolysis involved in cellular protein catabolic process | 31/3918 | 64/18723 | 8.71e-07 | 2.98e-05 | 31 |
GO:0031396 | Colorectum | AD | regulation of protein ubiquitination | 72/3918 | 210/18723 | 4.50e-06 | 1.21e-04 | 72 |
GO:2000059 | Colorectum | AD | negative regulation of ubiquitin-dependent protein catabolic process | 24/3918 | 48/18723 | 7.38e-06 | 1.81e-04 | 24 |
GO:0048872 | Colorectum | AD | homeostasis of number of cells | 87/3918 | 272/18723 | 1.16e-05 | 2.61e-04 | 87 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAMLG | SNV | Missense_Mutation | c.601N>T | p.Leu201Phe | p.L201F | P49069 | protein_coding | tolerated(0.32) | benign(0.003) | TCGA-95-7944-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CAMLG | SNV | Missense_Mutation | rs375153038 | c.31N>A | p.Gly11Arg | p.G11R | P49069 | protein_coding | deleterious_low_confidence(0) | benign(0.018) | TCGA-99-8025-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | gemzar | SD |
CAMLG | SNV | Missense_Mutation | c.865G>C | p.Asp289His | p.D289H | P49069 | protein_coding | tolerated(0.18) | benign(0.003) | TCGA-22-5491-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CAMLG | SNV | Missense_Mutation | rs765331970 | c.763N>A | p.Glu255Lys | p.E255K | P49069 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
CAMLG | SNV | Missense_Mutation | rs757373789 | c.446N>A | p.Arg149His | p.R149H | P49069 | protein_coding | tolerated_low_confidence(0.19) | benign(0.006) | TCGA-CD-A4MI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
CAMLG | insertion | In_Frame_Ins | novel | c.524_525insCAC | p.Ser175_Gln176insThr | p.S175_Q176insT | P49069 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
819 | CAMLG | NA | CYCLOSPORINE A | |||
819 | CAMLG | NA | CYCLOSPORINE | CYCLOSPORINE |
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