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Gene: CACNG8 |
Gene summary for CACNG8 |
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Gene information | Species | Human | Gene symbol | CACNG8 | Gene ID | 59283 |
Gene name | calcium voltage-gated channel auxiliary subunit gamma 8 | |
Gene Alias | CACNG8 | |
Cytomap | 19q13.42 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q8WXS5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
59283 | CACNG8 | HCC2_Meng | Human | Liver | HCC | 2.53e-06 | 1.45e-01 | 0.0107 |
59283 | CACNG8 | HCC1 | Human | Liver | HCC | 1.19e-14 | 1.38e+00 | 0.5336 |
59283 | CACNG8 | HCC2 | Human | Liver | HCC | 6.81e-31 | 2.29e+00 | 0.5341 |
59283 | CACNG8 | HCC5 | Human | Liver | HCC | 4.86e-36 | 1.90e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007259422 | Liver | HCC | establishment of protein localization to organelle | 299/7958 | 422/18723 | 1.06e-32 | 6.10e-30 | 299 |
GO:000703421 | Liver | HCC | vacuolar transport | 108/7958 | 157/18723 | 2.22e-11 | 8.69e-10 | 108 |
GO:000704121 | Liver | HCC | lysosomal transport | 76/7958 | 114/18723 | 1.56e-07 | 2.88e-06 | 76 |
GO:00315031 | Liver | HCC | protein-containing complex localization | 129/7958 | 220/18723 | 9.38e-07 | 1.42e-05 | 129 |
GO:007266521 | Liver | HCC | protein localization to vacuole | 48/7958 | 67/18723 | 1.27e-06 | 1.85e-05 | 48 |
GO:00726662 | Liver | HCC | establishment of protein localization to vacuole | 35/7958 | 49/18723 | 3.90e-05 | 3.85e-04 | 35 |
GO:004311221 | Liver | HCC | receptor metabolic process | 96/7958 | 166/18723 | 4.69e-05 | 4.50e-04 | 96 |
GO:00614621 | Liver | HCC | protein localization to lysosome | 33/7958 | 46/18723 | 5.63e-05 | 5.26e-04 | 33 |
GO:000689821 | Liver | HCC | receptor-mediated endocytosis | 134/7958 | 244/18723 | 5.73e-05 | 5.31e-04 | 134 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CACNG8 | SNV | Missense_Mutation | novel | c.304N>C | p.Val102Leu | p.V102L | Q8WXS5 | protein_coding | tolerated(0.62) | benign(0.043) | TCGA-63-A5MB-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
CACNG8 | SNV | Missense_Mutation | c.196N>A | p.Pro66Thr | p.P66T | Q8WXS5 | protein_coding | tolerated(0.08) | benign(0.007) | TCGA-66-2727-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CACNG8 | SNV | Missense_Mutation | novel | c.270N>G | p.Ile90Met | p.I90M | Q8WXS5 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-NC-A5HE-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
CACNG8 | insertion | Frame_Shift_Ins | novel | c.577dupG | p.Asp193GlyfsTer85 | p.D193Gfs*85 | Q8WXS5 | protein_coding | TCGA-85-7844-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
CACNG8 | SNV | Missense_Mutation | novel | c.206G>A | p.Gly69Glu | p.G69E | Q8WXS5 | protein_coding | tolerated_low_confidence(0.29) | benign(0.005) | TCGA-CN-5358-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
CACNG8 | SNV | Missense_Mutation | c.214N>A | p.Gly72Ser | p.G72S | Q8WXS5 | protein_coding | tolerated_low_confidence(0.28) | benign(0.003) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD | |
CACNG8 | SNV | Missense_Mutation | c.424N>C | p.Gly142Arg | p.G142R | Q8WXS5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CN-A63U-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CACNG8 | SNV | Missense_Mutation | rs770734902 | c.97N>A | p.Gly33Ser | p.G33S | Q8WXS5 | protein_coding | tolerated(0.77) | probably_damaging(0.999) | TCGA-CV-6954-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CACNG8 | SNV | Missense_Mutation | novel | c.112G>A | p.Ala38Thr | p.A38T | Q8WXS5 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-DQ-5631-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
CACNG8 | SNV | Missense_Mutation | rs750396252 | c.697N>A | p.Glu233Lys | p.E233K | Q8WXS5 | protein_coding | deleterious(0.04) | benign(0.063) | TCGA-P3-A5QF-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cetuximab | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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