|
Gene: CA5A |
Gene summary for CA5A |
Gene summary. |
Gene information | Species | Human | Gene symbol | CA5A | Gene ID | 763 |
Gene name | carbonic anhydrase 5A | |
Gene Alias | CA5 | |
Cytomap | 16q24.2 | |
Gene Type | protein-coding | GO ID | GO:0006730 | UniProtAcc | P35218 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
763 | CA5A | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.96e-08 | 1.97e-01 | 0.0155 |
763 | CA5A | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.40e-10 | 2.97e-01 | -0.1808 |
763 | CA5A | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.72e-02 | 2.69e-01 | 0.0216 |
763 | CA5A | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.29e-07 | 2.87e-01 | -0.0811 |
763 | CA5A | HTA11_78_2000001011 | Human | Colorectum | AD | 4.33e-07 | 2.59e-01 | -0.1088 |
763 | CA5A | HTA11_347_2000001011 | Human | Colorectum | AD | 1.02e-18 | 3.54e-01 | -0.1954 |
763 | CA5A | HTA11_411_2000001011 | Human | Colorectum | SER | 4.47e-04 | 3.21e-01 | -0.2602 |
763 | CA5A | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.68e-14 | 5.00e-01 | -0.1207 |
763 | CA5A | HTA11_83_2000001011 | Human | Colorectum | SER | 1.39e-12 | 3.85e-01 | -0.1526 |
763 | CA5A | HTA11_696_2000001011 | Human | Colorectum | AD | 1.10e-24 | 5.70e-01 | -0.1464 |
763 | CA5A | HTA11_866_2000001011 | Human | Colorectum | AD | 1.86e-20 | 4.45e-01 | -0.1001 |
763 | CA5A | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.31e-17 | 4.26e-01 | -0.059 |
763 | CA5A | HTA11_546_2000001011 | Human | Colorectum | AD | 1.71e-09 | 4.70e-01 | -0.0842 |
763 | CA5A | HTA11_7862_2000001011 | Human | Colorectum | AD | 6.48e-04 | 2.77e-01 | -0.0179 |
763 | CA5A | HTA11_866_3004761011 | Human | Colorectum | AD | 1.09e-08 | 2.39e-01 | 0.096 |
763 | CA5A | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.05e-03 | 2.97e-01 | 0.0528 |
763 | CA5A | HTA11_7663_2000001011 | Human | Colorectum | SER | 5.19e-04 | 3.24e-01 | 0.0131 |
763 | CA5A | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.62e-05 | 2.89e-01 | -0.0177 |
763 | CA5A | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.58e-07 | 2.83e-01 | 0.0338 |
763 | CA5A | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.59e-11 | 2.75e-01 | 0.0674 |
Page: 1 2 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006730 | Colorectum | AD | one-carbon metabolic process | 18/3918 | 40/18723 | 5.36e-04 | 5.74e-03 | 18 |
GO:00067301 | Colorectum | SER | one-carbon metabolic process | 15/2897 | 40/18723 | 5.71e-04 | 7.86e-03 | 15 |
GO:00067302 | Colorectum | MSS | one-carbon metabolic process | 15/3467 | 40/18723 | 3.72e-03 | 2.73e-02 | 15 |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CA5A | SNV | Missense_Mutation | c.80C>T | p.Ser27Leu | p.S27L | P35218 | protein_coding | tolerated(0.73) | benign(0) | TCGA-QF-A5YS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR | |
CA5A | SNV | Missense_Mutation | novel | c.585N>T | p.Arg195Ser | p.R195S | P35218 | protein_coding | deleterious(0) | benign(0.113) | TCGA-05-4397-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CA5A | SNV | Missense_Mutation | c.204N>A | p.Asn68Lys | p.N68K | P35218 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-39-5019-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CA5A | SNV | Missense_Mutation | c.319N>A | p.Asp107Asn | p.D107N | P35218 | protein_coding | tolerated(0.07) | probably_damaging(0.94) | TCGA-39-5028-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
CA5A | SNV | Missense_Mutation | novel | c.430A>G | p.Thr144Ala | p.T144A | P35218 | protein_coding | tolerated(0.1) | benign(0.014) | TCGA-52-7810-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CA5A | SNV | Missense_Mutation | novel | c.145N>T | p.His49Tyr | p.H49Y | P35218 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-T2-A6WX-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
CA5A | SNV | Missense_Mutation | rs745437622 | c.256T>C | p.Ser86Pro | p.S86P | P35218 | protein_coding | deleterious(0.01) | possibly_damaging(0.66) | TCGA-J9-A8CM-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
CA5A | SNV | Missense_Mutation | c.91N>C | p.Gly31Arg | p.G31R | P35218 | protein_coding | tolerated(0.15) | benign(0) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
763 | CA5A | ENZYME, DRUGGABLE GENOME | activator | 178100344 | HISTIDINE | |
763 | CA5A | ENZYME, DRUGGABLE GENOME | activator | 178101506 | AMPHETAMINE | |
763 | CA5A | ENZYME, DRUGGABLE GENOME | activator | 135651493 | HISTAMINE | |
763 | CA5A | ENZYME, DRUGGABLE GENOME | inhibitor | CHEMBL18 | ETHOXZOLAMIDE |
Page: 1 |