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Gene: C7orf43 |
Gene summary for C7ORF43 |
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Gene information | Species | Human | Gene symbol | C7orf43 | Gene ID | 55262 |
Gene name | trafficking protein particle complex subunit 14 | |
Gene Alias | C7orf43 | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | B3KNS5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55262 | C7orf43 | HCC1_Meng | Human | Liver | HCC | 1.07e-06 | 1.77e-02 | 0.0246 |
55262 | C7orf43 | S014 | Human | Liver | HCC | 1.88e-02 | 1.42e-01 | 0.2254 |
55262 | C7orf43 | S015 | Human | Liver | HCC | 1.88e-03 | 2.23e-01 | 0.2375 |
55262 | C7orf43 | S016 | Human | Liver | HCC | 1.06e-04 | 1.61e-01 | 0.2243 |
55262 | C7orf43 | S027 | Human | Liver | HCC | 5.31e-22 | 1.11e+00 | 0.2446 |
55262 | C7orf43 | S028 | Human | Liver | HCC | 2.62e-39 | 1.45e+00 | 0.2503 |
55262 | C7orf43 | S029 | Human | Liver | HCC | 8.36e-45 | 1.69e+00 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C7orf43 | SNV | Missense_Mutation | novel | c.1541G>A | p.Arg514His | p.R514H | Q8WVR3 | protein_coding | deleterious(0) | possibly_damaging(0.796) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C7orf43 | SNV | Missense_Mutation | c.1574N>A | p.Arg525Gln | p.R525Q | Q8WVR3 | protein_coding | tolerated(0.11) | benign(0.292) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
C7orf43 | SNV | Missense_Mutation | c.1307C>T | p.Thr436Met | p.T436M | Q8WVR3 | protein_coding | deleterious(0.01) | possibly_damaging(0.764) | TCGA-D1-A165-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
C7orf43 | SNV | Missense_Mutation | c.589T>C | p.Ser197Pro | p.S197P | Q8WVR3 | protein_coding | tolerated(0.08) | benign(0.354) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C7orf43 | SNV | Missense_Mutation | rs866454876 | c.1100G>A | p.Arg367His | p.R367H | Q8WVR3 | protein_coding | deleterious(0.02) | possibly_damaging(0.775) | TCGA-DI-A0WH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C7orf43 | deletion | Frame_Shift_Del | novel | c.965delG | p.Gly322ValfsTer16 | p.G322Vfs*16 | Q8WVR3 | protein_coding | TCGA-B5-A11O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
C7orf43 | SNV | Missense_Mutation | c.1561C>A | p.Gln521Lys | p.Q521K | Q8WVR3 | protein_coding | deleterious(0.02) | probably_damaging(0.932) | TCGA-CC-5261-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
C7orf43 | SNV | Missense_Mutation | c.1183N>T | p.Asn395Tyr | p.N395Y | Q8WVR3 | protein_coding | deleterious(0) | possibly_damaging(0.761) | TCGA-DD-A4NG-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
C7orf43 | SNV | Missense_Mutation | novel | c.556N>C | p.Asp186His | p.D186H | Q8WVR3 | protein_coding | deleterious(0.01) | possibly_damaging(0.875) | TCGA-55-8301-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PR |
C7orf43 | SNV | Missense_Mutation | novel | c.723N>T | p.Lys241Asn | p.K241N | Q8WVR3 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-86-7701-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | etoposide | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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