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Gene: C1QTNF6 |
Gene summary for C1QTNF6 |
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Gene information | Species | Human | Gene symbol | C1QTNF6 | Gene ID | 114904 |
Gene name | C1q and TNF related 6 | |
Gene Alias | CTFP6 | |
Cytomap | 22q12.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024R1J0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
114904 | C1QTNF6 | P2T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.43e-01 | 0.1177 |
114904 | C1QTNF6 | P4T-E | Human | Esophagus | ESCC | 7.93e-07 | 2.00e-01 | 0.1323 |
114904 | C1QTNF6 | P8T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.32e-01 | 0.0889 |
114904 | C1QTNF6 | P9T-E | Human | Esophagus | ESCC | 3.82e-08 | 2.18e-01 | 0.1131 |
114904 | C1QTNF6 | P10T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.24e-01 | 0.116 |
114904 | C1QTNF6 | P11T-E | Human | Esophagus | ESCC | 1.85e-29 | 1.14e+00 | 0.1426 |
114904 | C1QTNF6 | P17T-E | Human | Esophagus | ESCC | 1.49e-02 | 1.38e-01 | 0.1278 |
114904 | C1QTNF6 | P19T-E | Human | Esophagus | ESCC | 1.65e-10 | 6.70e-01 | 0.1662 |
114904 | C1QTNF6 | P21T-E | Human | Esophagus | ESCC | 1.88e-11 | 2.39e-01 | 0.1617 |
114904 | C1QTNF6 | P22T-E | Human | Esophagus | ESCC | 1.62e-13 | 3.07e-01 | 0.1236 |
114904 | C1QTNF6 | P24T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.69e-01 | 0.1287 |
114904 | C1QTNF6 | P26T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.03e-01 | 0.1276 |
114904 | C1QTNF6 | P32T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.12e-01 | 0.1666 |
114904 | C1QTNF6 | P37T-E | Human | Esophagus | ESCC | 5.50e-16 | 3.45e-01 | 0.1371 |
114904 | C1QTNF6 | P40T-E | Human | Esophagus | ESCC | 1.20e-04 | 2.19e-01 | 0.109 |
114904 | C1QTNF6 | P42T-E | Human | Esophagus | ESCC | 2.42e-06 | 2.63e-01 | 0.1175 |
114904 | C1QTNF6 | P44T-E | Human | Esophagus | ESCC | 1.67e-06 | 4.07e-01 | 0.1096 |
114904 | C1QTNF6 | P47T-E | Human | Esophagus | ESCC | 8.56e-12 | 2.28e-01 | 0.1067 |
114904 | C1QTNF6 | P49T-E | Human | Esophagus | ESCC | 3.75e-07 | 5.95e-01 | 0.1768 |
114904 | C1QTNF6 | P52T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.09e-01 | 0.1555 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C1QTNF6 | SNV | Missense_Mutation | c.333G>T | p.Met111Ile | p.M111I | Q9BXI9 | protein_coding | tolerated(0.39) | benign(0.006) | TCGA-55-6984-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | chemo | PD | |
C1QTNF6 | SNV | Missense_Mutation | c.661G>T | p.Ala221Ser | p.A221S | Q9BXI9 | protein_coding | tolerated(0.06) | probably_damaging(0.992) | TCGA-21-1071-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
C1QTNF6 | SNV | Missense_Mutation | novel | c.557N>T | p.Pro186Leu | p.P186L | Q9BXI9 | protein_coding | tolerated(0.63) | benign(0.343) | TCGA-21-1079-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
C1QTNF6 | SNV | Missense_Mutation | c.333N>T | p.Met111Ile | p.M111I | Q9BXI9 | protein_coding | tolerated(0.39) | benign(0.006) | TCGA-22-5491-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
C1QTNF6 | SNV | Missense_Mutation | c.232N>T | p.Gly78Cys | p.G78C | Q9BXI9 | protein_coding | tolerated(0.19) | possibly_damaging(0.864) | TCGA-43-5668-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Other, specify in notesMAGE3-AS15-NSC-003 | clinical | PD | |
C1QTNF6 | SNV | Missense_Mutation | novel | c.5N>G | p.Gln2Arg | p.Q2R | Q9BXI9 | protein_coding | tolerated_low_confidence(0.32) | benign(0) | TCGA-BA-4078-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
C1QTNF6 | SNV | Missense_Mutation | rs201178136 | c.757N>T | p.Arg253Cys | p.R253C | Q9BXI9 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
C1QTNF6 | SNV | Missense_Mutation | c.484A>G | p.Thr162Ala | p.T162A | Q9BXI9 | protein_coding | tolerated(1) | benign(0.009) | TCGA-BR-4256-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
C1QTNF6 | SNV | Missense_Mutation | c.305N>G | p.Pro102Arg | p.P102R | Q9BXI9 | protein_coding | tolerated(1) | benign(0) | TCGA-BR-8059-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
C1QTNF6 | SNV | Missense_Mutation | rs751594408 | c.235N>T | p.Arg79Cys | p.R79C | Q9BXI9 | protein_coding | tolerated(0.07) | benign(0) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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