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Gene: C1QA |
Gene summary for C1QA |
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Gene information | Species | Human | Gene symbol | C1QA | Gene ID | 712 |
Gene name | complement C1q A chain | |
Gene Alias | C1QA | |
Cytomap | 1p36.12 | |
Gene Type | protein-coding | GO ID | GO:0001774 | UniProtAcc | A0A024RAG6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
712 | C1QA | GSM4909287 | Human | Breast | IDC | 1.85e-03 | 1.66e-01 | 0.2057 |
712 | C1QA | NCCBC11 | Human | Breast | DCIS | 3.48e-09 | 7.76e-01 | 0.1232 |
712 | C1QA | NCCBC14 | Human | Breast | DCIS | 7.58e-07 | 3.87e-01 | 0.2021 |
712 | C1QA | NCCBC3 | Human | Breast | DCIS | 1.79e-52 | 1.20e+00 | 0.1198 |
712 | C1QA | NCCBC5 | Human | Breast | DCIS | 1.34e-14 | 6.50e-01 | 0.2046 |
712 | C1QA | P2 | Human | Breast | IDC | 1.18e-02 | 1.88e-01 | 0.21 |
712 | C1QA | HCC1_Meng | Human | Liver | HCC | 3.17e-28 | 4.00e-02 | 0.0246 |
712 | C1QA | cirrhotic2 | Human | Liver | Cirrhotic | 5.59e-10 | 8.81e-02 | 0.0201 |
712 | C1QA | cirrhotic3 | Human | Liver | Cirrhotic | 6.50e-07 | -9.00e-06 | 0.0215 |
712 | C1QA | HCC2 | Human | Liver | HCC | 6.27e-10 | 1.37e+00 | 0.5341 |
712 | C1QA | Pt13.a | Human | Liver | HCC | 9.40e-28 | 1.07e+00 | 0.021 |
712 | C1QA | Pt13.b | Human | Liver | HCC | 5.26e-19 | 4.53e-01 | 0.0251 |
712 | C1QA | Pt13.c | Human | Liver | HCC | 1.54e-48 | 1.64e+00 | 0.0076 |
712 | C1QA | Pt14.d | Human | Liver | HCC | 4.32e-37 | 1.17e+00 | 0.0143 |
712 | C1QA | C21 | Human | Oral cavity | OSCC | 2.44e-91 | 2.94e+00 | 0.2678 |
712 | C1QA | C30 | Human | Oral cavity | OSCC | 3.41e-24 | 8.55e-01 | 0.3055 |
712 | C1QA | C38 | Human | Oral cavity | OSCC | 2.16e-03 | 6.46e-01 | 0.172 |
712 | C1QA | C51 | Human | Oral cavity | OSCC | 4.10e-16 | 6.56e-01 | 0.2674 |
712 | C1QA | C57 | Human | Oral cavity | OSCC | 4.49e-02 | 1.73e-01 | 0.1679 |
712 | C1QA | C07 | Human | Oral cavity | OSCC | 3.06e-03 | 4.95e-01 | 0.2491 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001003814 | Breast | IDC | response to metal ion | 65/1434 | 373/18723 | 2.95e-10 | 3.42e-08 | 65 |
GO:007099714 | Breast | IDC | neuron death | 57/1434 | 361/18723 | 1.31e-07 | 7.38e-06 | 57 |
GO:000756813 | Breast | IDC | aging | 52/1434 | 339/18723 | 1.14e-06 | 5.10e-05 | 52 |
GO:190121414 | Breast | IDC | regulation of neuron death | 48/1434 | 319/18723 | 5.01e-06 | 1.69e-04 | 48 |
GO:190121614 | Breast | IDC | positive regulation of neuron death | 19/1434 | 97/18723 | 1.22e-04 | 2.25e-03 | 19 |
GO:004206311 | Breast | IDC | gliogenesis | 39/1434 | 301/18723 | 8.63e-04 | 1.00e-02 | 39 |
GO:00100011 | Breast | IDC | glial cell differentiation | 31/1434 | 225/18723 | 1.04e-03 | 1.15e-02 | 31 |
GO:00069596 | Breast | IDC | humoral immune response | 40/1434 | 317/18723 | 1.25e-03 | 1.33e-02 | 40 |
GO:0010039 | Breast | IDC | response to iron ion | 8/1434 | 32/18723 | 2.32e-03 | 2.10e-02 | 8 |
GO:00022532 | Breast | IDC | activation of immune response | 43/1434 | 375/18723 | 5.16e-03 | 3.84e-02 | 43 |
GO:001003824 | Breast | DCIS | response to metal ion | 65/1390 | 373/18723 | 8.03e-11 | 9.88e-09 | 65 |
GO:007099724 | Breast | DCIS | neuron death | 57/1390 | 361/18723 | 4.56e-08 | 2.84e-06 | 57 |
GO:190121421 | Breast | DCIS | regulation of neuron death | 48/1390 | 319/18723 | 2.13e-06 | 7.79e-05 | 48 |
GO:000756823 | Breast | DCIS | aging | 50/1390 | 339/18723 | 2.38e-06 | 8.46e-05 | 50 |
GO:190121622 | Breast | DCIS | positive regulation of neuron death | 20/1390 | 97/18723 | 2.45e-05 | 5.68e-04 | 20 |
GO:00420632 | Breast | DCIS | gliogenesis | 39/1390 | 301/18723 | 4.76e-04 | 6.25e-03 | 39 |
GO:00100012 | Breast | DCIS | glial cell differentiation | 31/1390 | 225/18723 | 6.24e-04 | 7.87e-03 | 31 |
GO:00100391 | Breast | DCIS | response to iron ion | 8/1390 | 32/18723 | 1.90e-03 | 1.81e-02 | 8 |
GO:000225311 | Breast | DCIS | activation of immune response | 43/1390 | 375/18723 | 2.96e-03 | 2.54e-02 | 43 |
GO:000695911 | Breast | DCIS | humoral immune response | 37/1390 | 317/18723 | 4.16e-03 | 3.29e-02 | 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0502023 | Breast | IDC | Prion disease | 102/867 | 273/8465 | 3.70e-34 | 4.01e-32 | 3.00e-32 | 102 |
hsa0517124 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0502033 | Breast | IDC | Prion disease | 102/867 | 273/8465 | 3.70e-34 | 4.01e-32 | 3.00e-32 | 102 |
hsa0517134 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0502043 | Breast | DCIS | Prion disease | 100/846 | 273/8465 | 1.44e-33 | 1.55e-31 | 1.14e-31 | 100 |
hsa0502053 | Breast | DCIS | Prion disease | 100/846 | 273/8465 | 1.44e-33 | 1.55e-31 | 1.14e-31 | 100 |
hsa0517122 | Liver | Cirrhotic | Coronavirus disease - COVID-19 | 136/2530 | 232/8465 | 3.28e-20 | 1.82e-18 | 1.12e-18 | 136 |
hsa0502014 | Liver | Cirrhotic | Prion disease | 152/2530 | 273/8465 | 1.84e-19 | 8.78e-18 | 5.41e-18 | 152 |
hsa046102 | Liver | Cirrhotic | Complement and coagulation cascades | 48/2530 | 86/8465 | 4.41e-07 | 5.44e-06 | 3.35e-06 | 48 |
hsa05133 | Liver | Cirrhotic | Pertussis | 37/2530 | 76/8465 | 4.17e-04 | 2.57e-03 | 1.58e-03 | 37 |
hsa04936 | Liver | Cirrhotic | Alcoholic liver disease | 60/2530 | 142/8465 | 1.07e-03 | 5.85e-03 | 3.61e-03 | 60 |
hsa0517132 | Liver | Cirrhotic | Coronavirus disease - COVID-19 | 136/2530 | 232/8465 | 3.28e-20 | 1.82e-18 | 1.12e-18 | 136 |
hsa0502015 | Liver | Cirrhotic | Prion disease | 152/2530 | 273/8465 | 1.84e-19 | 8.78e-18 | 5.41e-18 | 152 |
hsa046103 | Liver | Cirrhotic | Complement and coagulation cascades | 48/2530 | 86/8465 | 4.41e-07 | 5.44e-06 | 3.35e-06 | 48 |
hsa051331 | Liver | Cirrhotic | Pertussis | 37/2530 | 76/8465 | 4.17e-04 | 2.57e-03 | 1.58e-03 | 37 |
hsa049361 | Liver | Cirrhotic | Alcoholic liver disease | 60/2530 | 142/8465 | 1.07e-03 | 5.85e-03 | 3.61e-03 | 60 |
hsa0502022 | Liver | HCC | Prion disease | 195/4020 | 273/8465 | 3.26e-16 | 1.56e-14 | 8.67e-15 | 195 |
hsa0517142 | Liver | HCC | Coronavirus disease - COVID-19 | 167/4020 | 232/8465 | 1.50e-14 | 4.19e-13 | 2.33e-13 | 167 |
hsa049362 | Liver | HCC | Alcoholic liver disease | 89/4020 | 142/8465 | 1.73e-04 | 8.53e-04 | 4.75e-04 | 89 |
hsa046104 | Liver | HCC | Complement and coagulation cascades | 57/4020 | 86/8465 | 3.19e-04 | 1.45e-03 | 8.04e-04 | 57 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C1QA | SNV | Missense_Mutation | rs754597784 | c.475N>C | p.Tyr159His | p.Y159H | P02745 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-A490-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD |
C1QA | SNV | Missense_Mutation | c.601N>T | p.Val201Leu | p.V201L | P02745 | protein_coding | tolerated(0.33) | benign(0.006) | TCGA-55-A490-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD | |
C1QA | SNV | Missense_Mutation | c.712N>A | p.Gly238Ser | p.G238S | P02745 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-69-7980-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C1QA | SNV | Missense_Mutation | c.713N>T | p.Gly238Val | p.G238V | P02745 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-69-7980-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C1QA | SNV | Missense_Mutation | rs767339831 | c.635N>A | p.Gly212Asp | p.G212D | P02745 | protein_coding | tolerated(0.16) | possibly_damaging(0.902) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
C1QA | SNV | Missense_Mutation | novel | c.242N>G | p.Lys81Arg | p.K81R | P02745 | protein_coding | tolerated(0.51) | benign(0.006) | TCGA-NC-A5HI-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
C1QA | SNV | Missense_Mutation | novel | c.406N>A | p.Val136Ile | p.V136I | P02745 | protein_coding | tolerated(1) | benign(0.006) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C1QA | SNV | Missense_Mutation | novel | c.97A>G | p.Lys33Glu | p.K33E | P02745 | protein_coding | tolerated(0.21) | benign(0.006) | TCGA-HD-A6HZ-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
C1QA | SNV | Missense_Mutation | rs373380166 | c.124N>T | p.Arg42Trp | p.R42W | P02745 | protein_coding | deleterious(0.01) | benign(0.012) | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
712 | C1QA | DRUGGABLE GENOME, CELL SURFACE | IMMUNE GLOBULIN |
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