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Gene: C12orf65 |
Gene summary for C12ORF65 |
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Gene information | Species | Human | Gene symbol | C12orf65 | Gene ID | 91574 |
Gene name | mitochondrial translation release factor in rescue | |
Gene Alias | C12orf65 | |
Cytomap | 12q24.31 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | Q9H3J6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91574 | C12orf65 | LZE4T | Human | Esophagus | ESCC | 2.14e-04 | 2.27e-01 | 0.0811 |
91574 | C12orf65 | LZE7T | Human | Esophagus | ESCC | 2.47e-04 | 2.77e-01 | 0.0667 |
91574 | C12orf65 | LZE22D1 | Human | Esophagus | HGIN | 1.65e-02 | 9.15e-02 | 0.0595 |
91574 | C12orf65 | LZE24T | Human | Esophagus | ESCC | 6.85e-14 | 3.54e-01 | 0.0596 |
91574 | C12orf65 | LZE21T | Human | Esophagus | ESCC | 2.10e-04 | 3.59e-01 | 0.0655 |
91574 | C12orf65 | LZE6T | Human | Esophagus | ESCC | 2.23e-02 | 2.50e-01 | 0.0845 |
91574 | C12orf65 | P1T-E | Human | Esophagus | ESCC | 3.61e-13 | 6.85e-01 | 0.0875 |
91574 | C12orf65 | P2T-E | Human | Esophagus | ESCC | 9.82e-73 | 1.44e+00 | 0.1177 |
91574 | C12orf65 | P4T-E | Human | Esophagus | ESCC | 7.20e-29 | 8.00e-01 | 0.1323 |
91574 | C12orf65 | P5T-E | Human | Esophagus | ESCC | 6.72e-15 | 3.05e-01 | 0.1327 |
91574 | C12orf65 | P8T-E | Human | Esophagus | ESCC | 3.68e-24 | 3.97e-01 | 0.0889 |
91574 | C12orf65 | P9T-E | Human | Esophagus | ESCC | 7.76e-14 | 1.69e-01 | 0.1131 |
91574 | C12orf65 | P10T-E | Human | Esophagus | ESCC | 1.44e-22 | 4.88e-01 | 0.116 |
91574 | C12orf65 | P11T-E | Human | Esophagus | ESCC | 4.98e-16 | 6.97e-01 | 0.1426 |
91574 | C12orf65 | P12T-E | Human | Esophagus | ESCC | 6.85e-26 | 5.14e-01 | 0.1122 |
91574 | C12orf65 | P15T-E | Human | Esophagus | ESCC | 6.44e-24 | 6.39e-01 | 0.1149 |
91574 | C12orf65 | P16T-E | Human | Esophagus | ESCC | 5.21e-36 | 5.66e-01 | 0.1153 |
91574 | C12orf65 | P17T-E | Human | Esophagus | ESCC | 6.86e-04 | 3.25e-01 | 0.1278 |
91574 | C12orf65 | P20T-E | Human | Esophagus | ESCC | 1.22e-18 | 4.28e-01 | 0.1124 |
91574 | C12orf65 | P21T-E | Human | Esophagus | ESCC | 1.74e-33 | 8.10e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C12orf65 | deletion | Frame_Shift_Del | novel | c.449delN | p.Lys152ArgfsTer24 | p.K152Rfs*24 | Q9H3J6 | protein_coding | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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