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Gene: BZW1 |
Gene summary for BZW1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | BZW1 | Gene ID | 9689 |
Gene name | basic leucine zipper and W2 domains 1 | |
Gene Alias | BZAP45 | |
Cytomap | 2q33.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024R3Z6 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9689 | BZW1 | GSM4909282 | Human | Breast | IDC | 4.08e-04 | -3.58e-01 | -0.0288 |
9689 | BZW1 | GSM4909286 | Human | Breast | IDC | 1.46e-15 | -4.78e-01 | 0.1081 |
9689 | BZW1 | GSM4909293 | Human | Breast | IDC | 5.40e-03 | 4.55e-02 | 0.1581 |
9689 | BZW1 | GSM4909296 | Human | Breast | IDC | 1.62e-12 | -3.71e-01 | 0.1524 |
9689 | BZW1 | GSM4909297 | Human | Breast | IDC | 4.38e-12 | -1.52e-01 | 0.1517 |
9689 | BZW1 | GSM4909298 | Human | Breast | IDC | 1.40e-04 | -3.25e-01 | 0.1551 |
9689 | BZW1 | GSM4909302 | Human | Breast | IDC | 2.48e-13 | -4.93e-01 | 0.1545 |
9689 | BZW1 | GSM4909304 | Human | Breast | IDC | 1.15e-02 | 1.85e-01 | 0.1636 |
9689 | BZW1 | GSM4909309 | Human | Breast | IDC | 2.20e-10 | -4.44e-01 | 0.0483 |
9689 | BZW1 | GSM4909311 | Human | Breast | IDC | 1.94e-39 | -5.26e-01 | 0.1534 |
9689 | BZW1 | GSM4909312 | Human | Breast | IDC | 4.24e-12 | -3.19e-01 | 0.1552 |
9689 | BZW1 | GSM4909319 | Human | Breast | IDC | 4.06e-43 | -6.31e-01 | 0.1563 |
9689 | BZW1 | GSM4909320 | Human | Breast | IDC | 1.22e-10 | -5.86e-01 | 0.1575 |
9689 | BZW1 | GSM4909321 | Human | Breast | IDC | 1.17e-31 | -6.02e-01 | 0.1559 |
9689 | BZW1 | ctrl6 | Human | Breast | Precancer | 1.83e-03 | 4.50e-01 | -0.0061 |
9689 | BZW1 | brca2 | Human | Breast | Precancer | 4.97e-06 | 2.85e-01 | -0.024 |
9689 | BZW1 | brca3 | Human | Breast | Precancer | 3.00e-03 | 2.63e-01 | -0.0263 |
9689 | BZW1 | NCCBC14 | Human | Breast | DCIS | 6.86e-17 | 2.74e-01 | 0.2021 |
9689 | BZW1 | NCCBC2 | Human | Breast | DCIS | 2.58e-02 | -4.08e-01 | 0.1554 |
9689 | BZW1 | NCCBC5 | Human | Breast | DCIS | 4.03e-12 | -5.31e-02 | 0.2046 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BZW1 | SNV | Missense_Mutation | novel | c.530N>T | p.Ser177Leu | p.S177L | Q7L1Q6 | protein_coding | tolerated(0.21) | benign(0.089) | TCGA-AX-A3FT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BZW1 | SNV | Missense_Mutation | c.92N>T | p.Ser31Phe | p.S31F | Q7L1Q6 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.962) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
BZW1 | SNV | Missense_Mutation | c.295G>T | p.Ala99Ser | p.A99S | Q7L1Q6 | protein_coding | tolerated(0.09) | benign(0.119) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
BZW1 | SNV | Missense_Mutation | novel | c.343G>T | p.Gly115Cys | p.G115C | Q7L1Q6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
BZW1 | SNV | Missense_Mutation | novel | c.1174N>G | p.Gln392Glu | p.Q392E | Q7L1Q6 | protein_coding | tolerated(0.1) | benign(0.134) | TCGA-B5-A3F9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BZW1 | SNV | Missense_Mutation | rs780739826 | c.896N>A | p.Arg299His | p.R299H | Q7L1Q6 | protein_coding | tolerated(0.07) | benign(0.213) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BZW1 | SNV | Missense_Mutation | rs867499216 | c.392C>T | p.Ala131Val | p.A131V | Q7L1Q6 | protein_coding | tolerated(0.25) | benign(0.014) | TCGA-B5-A5OC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
BZW1 | SNV | Missense_Mutation | c.945N>C | p.Lys315Asn | p.K315N | Q7L1Q6 | protein_coding | deleterious(0.03) | benign(0.296) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BZW1 | SNV | Missense_Mutation | novel | c.370N>T | p.Arg124Cys | p.R124C | Q7L1Q6 | protein_coding | deleterious(0.03) | benign(0.011) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BZW1 | SNV | Missense_Mutation | c.92N>A | p.Ser31Tyr | p.S31Y | Q7L1Q6 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.962) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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