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Gene: BUD13 |
Gene summary for BUD13 |
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Gene information | Species | Human | Gene symbol | BUD13 | Gene ID | 84811 |
Gene name | BUD13 homolog | |
Gene Alias | Cwc26 | |
Cytomap | 11q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | Q9BRD0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84811 | BUD13 | LZE4T | Human | Esophagus | ESCC | 1.09e-02 | 1.37e-01 | 0.0811 |
84811 | BUD13 | LZE24T | Human | Esophagus | ESCC | 5.15e-10 | 2.92e-01 | 0.0596 |
84811 | BUD13 | P1T-E | Human | Esophagus | ESCC | 5.68e-05 | 2.16e-01 | 0.0875 |
84811 | BUD13 | P2T-E | Human | Esophagus | ESCC | 5.13e-17 | 2.23e-01 | 0.1177 |
84811 | BUD13 | P4T-E | Human | Esophagus | ESCC | 2.32e-19 | 3.90e-01 | 0.1323 |
84811 | BUD13 | P5T-E | Human | Esophagus | ESCC | 1.26e-07 | 1.75e-01 | 0.1327 |
84811 | BUD13 | P8T-E | Human | Esophagus | ESCC | 3.27e-07 | 1.26e-01 | 0.0889 |
84811 | BUD13 | P9T-E | Human | Esophagus | ESCC | 1.18e-04 | 1.44e-01 | 0.1131 |
84811 | BUD13 | P10T-E | Human | Esophagus | ESCC | 2.73e-10 | 2.40e-01 | 0.116 |
84811 | BUD13 | P11T-E | Human | Esophagus | ESCC | 1.13e-08 | 2.83e-01 | 0.1426 |
84811 | BUD13 | P12T-E | Human | Esophagus | ESCC | 3.88e-23 | 4.00e-01 | 0.1122 |
84811 | BUD13 | P15T-E | Human | Esophagus | ESCC | 1.10e-06 | 1.56e-01 | 0.1149 |
84811 | BUD13 | P16T-E | Human | Esophagus | ESCC | 1.50e-17 | 3.02e-01 | 0.1153 |
84811 | BUD13 | P17T-E | Human | Esophagus | ESCC | 4.41e-05 | 1.98e-01 | 0.1278 |
84811 | BUD13 | P20T-E | Human | Esophagus | ESCC | 6.24e-10 | 2.19e-01 | 0.1124 |
84811 | BUD13 | P21T-E | Human | Esophagus | ESCC | 1.27e-16 | 3.29e-01 | 0.1617 |
84811 | BUD13 | P22T-E | Human | Esophagus | ESCC | 1.00e-08 | 1.65e-01 | 0.1236 |
84811 | BUD13 | P23T-E | Human | Esophagus | ESCC | 1.63e-07 | 1.68e-01 | 0.108 |
84811 | BUD13 | P24T-E | Human | Esophagus | ESCC | 5.57e-06 | 1.25e-01 | 0.1287 |
84811 | BUD13 | P26T-E | Human | Esophagus | ESCC | 2.58e-20 | 3.97e-01 | 0.1276 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:0000377111 | Esophagus | ESCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0000398111 | Esophagus | ESCC | mRNA splicing, via spliceosome | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BUD13 | SNV | Missense_Mutation | rs758106000 | c.217N>T | p.Asp73Tyr | p.D73Y | Q9BRD0 | protein_coding | deleterious(0) | benign(0.186) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
BUD13 | SNV | Missense_Mutation | c.878N>T | p.Arg293Ile | p.R293I | Q9BRD0 | protein_coding | deleterious(0.03) | possibly_damaging(0.897) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BUD13 | SNV | Missense_Mutation | novel | c.1585N>A | p.Glu529Lys | p.E529K | Q9BRD0 | protein_coding | tolerated(0.08) | probably_damaging(0.977) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BUD13 | SNV | Missense_Mutation | novel | c.426N>T | p.Lys142Asn | p.K142N | Q9BRD0 | protein_coding | deleterious(0) | benign(0.063) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BUD13 | SNV | Missense_Mutation | novel | c.608N>A | p.Pro203Gln | p.P203Q | Q9BRD0 | protein_coding | deleterious(0.05) | benign(0.101) | TCGA-BG-A221-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BUD13 | SNV | Missense_Mutation | novel | c.1351N>A | p.Ala451Thr | p.A451T | Q9BRD0 | protein_coding | tolerated(0.54) | benign(0.003) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
BUD13 | SNV | Missense_Mutation | c.1391N>A | p.Arg464Gln | p.R464Q | Q9BRD0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BUD13 | SNV | Missense_Mutation | novel | c.332N>G | p.Glu111Gly | p.E111G | Q9BRD0 | protein_coding | deleterious(0.01) | possibly_damaging(0.811) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BUD13 | SNV | Missense_Mutation | novel | c.1724N>T | p.Arg575Ile | p.R575I | Q9BRD0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
BUD13 | SNV | Missense_Mutation | rs145445291 | c.328N>G | p.Asn110Asp | p.N110D | Q9BRD0 | protein_coding | tolerated(0.34) | benign(0) | TCGA-EY-A1GD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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