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Gene: BRAP |
Gene summary for BRAP |
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Gene information | Species | Human | Gene symbol | BRAP | Gene ID | 8315 |
Gene name | BRCA1 associated protein | |
Gene Alias | BRAP2 | |
Cytomap | 12q24.12 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q59H81 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8315 | BRAP | LZE4T | Human | Esophagus | ESCC | 5.30e-04 | 7.72e-02 | 0.0811 |
8315 | BRAP | LZE20T | Human | Esophagus | ESCC | 6.89e-08 | 1.97e-01 | 0.0662 |
8315 | BRAP | LZE24T | Human | Esophagus | ESCC | 1.08e-04 | 2.31e-01 | 0.0596 |
8315 | BRAP | P1T-E | Human | Esophagus | ESCC | 2.71e-11 | 3.77e-01 | 0.0875 |
8315 | BRAP | P2T-E | Human | Esophagus | ESCC | 1.02e-27 | 5.06e-01 | 0.1177 |
8315 | BRAP | P4T-E | Human | Esophagus | ESCC | 9.83e-12 | 3.27e-01 | 0.1323 |
8315 | BRAP | P5T-E | Human | Esophagus | ESCC | 4.99e-09 | 1.98e-01 | 0.1327 |
8315 | BRAP | P8T-E | Human | Esophagus | ESCC | 8.34e-16 | 2.39e-01 | 0.0889 |
8315 | BRAP | P9T-E | Human | Esophagus | ESCC | 5.05e-12 | 1.41e-01 | 0.1131 |
8315 | BRAP | P10T-E | Human | Esophagus | ESCC | 2.22e-16 | 1.97e-01 | 0.116 |
8315 | BRAP | P11T-E | Human | Esophagus | ESCC | 3.26e-16 | 4.84e-01 | 0.1426 |
8315 | BRAP | P12T-E | Human | Esophagus | ESCC | 2.33e-10 | 1.93e-01 | 0.1122 |
8315 | BRAP | P15T-E | Human | Esophagus | ESCC | 5.19e-25 | 3.12e-01 | 0.1149 |
8315 | BRAP | P16T-E | Human | Esophagus | ESCC | 5.65e-14 | 2.54e-01 | 0.1153 |
8315 | BRAP | P17T-E | Human | Esophagus | ESCC | 1.50e-04 | 2.00e-01 | 0.1278 |
8315 | BRAP | P19T-E | Human | Esophagus | ESCC | 1.58e-03 | 4.91e-01 | 0.1662 |
8315 | BRAP | P20T-E | Human | Esophagus | ESCC | 2.05e-17 | 3.63e-01 | 0.1124 |
8315 | BRAP | P21T-E | Human | Esophagus | ESCC | 2.62e-21 | 3.19e-01 | 0.1617 |
8315 | BRAP | P22T-E | Human | Esophagus | ESCC | 1.31e-17 | 2.14e-01 | 0.1236 |
8315 | BRAP | P23T-E | Human | Esophagus | ESCC | 7.74e-20 | 4.37e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000726510 | Esophagus | ESCC | Ras protein signal transduction | 201/8552 | 337/18723 | 1.44e-07 | 2.30e-06 | 201 |
GO:00072659 | Oral cavity | OSCC | Ras protein signal transduction | 185/7305 | 337/18723 | 1.95e-09 | 4.60e-08 | 185 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BRAP | SNV | Missense_Mutation | rs745860025 | c.1286N>A | p.Arg429Gln | p.R429Q | Q7Z569 | protein_coding | tolerated(0.18) | benign(0.01) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BRAP | SNV | Missense_Mutation | c.90N>C | p.Glu30Asp | p.E30D | Q7Z569 | protein_coding | tolerated(0.51) | benign(0.142) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
BRAP | SNV | Missense_Mutation | rs370834616 | c.1055C>T | p.Thr352Met | p.T352M | Q7Z569 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
BRAP | SNV | Missense_Mutation | c.866N>T | p.Ser289Ile | p.S289I | Q7Z569 | protein_coding | deleterious(0.03) | possibly_damaging(0.46) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BRAP | SNV | Missense_Mutation | novel | c.1225N>C | p.Ser409Pro | p.S409P | Q7Z569 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
BRAP | SNV | Missense_Mutation | rs770298646 | c.671G>A | p.Arg224His | p.R224H | Q7Z569 | protein_coding | tolerated(0.06) | probably_damaging(0.987) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
BRAP | SNV | Missense_Mutation | novel | c.910N>T | p.Arg304Trp | p.R304W | Q7Z569 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AX-A2HG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BRAP | SNV | Missense_Mutation | c.1259G>A | p.Arg420Gln | p.R420Q | Q7Z569 | protein_coding | deleterious(0) | benign(0.072) | TCGA-B5-A11N-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BRAP | SNV | Missense_Mutation | novel | c.1319A>T | p.Asn440Ile | p.N440I | Q7Z569 | protein_coding | deleterious(0.02) | probably_damaging(0.916) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
BRAP | SNV | Missense_Mutation | novel | c.1757N>A | p.Gly586Asp | p.G586D | Q7Z569 | protein_coding | tolerated(0.2) | probably_damaging(0.998) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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