![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: BEND7 |
Gene summary for BEND7 |
![]() |
Gene information | Species | Human | Gene symbol | BEND7 | Gene ID | 222389 |
Gene name | BEN domain containing 7 | |
Gene Alias | C10orf30 | |
Cytomap | 10p13 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8N7W2 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
222389 | BEND7 | GSM5252132_BPH389PrGF | Human | Prostate | BPH | 1.75e-04 | 6.40e-01 | -0.2247 |
222389 | BEND7 | GSM5252133_BPH389PrSF | Human | Prostate | BPH | 1.39e-03 | 8.39e-01 | -0.2027 |
222389 | BEND7 | GSM5252135_BPH511PrPUr_Fcol_3GEX | Human | Prostate | BPH | 1.48e-29 | 8.21e-01 | -0.1833 |
222389 | BEND7 | 047563_1562-all-cells | Human | Prostate | BPH | 1.61e-02 | 1.62e-01 | 0.0791 |
222389 | BEND7 | 048752_1579-all-cells | Human | Prostate | BPH | 2.60e-19 | 4.86e-01 | 0.1008 |
222389 | BEND7 | 052095_1628-all-cells | Human | Prostate | BPH | 1.79e-02 | 2.21e-01 | 0.1032 |
222389 | BEND7 | 052097_1595-all-cells | Human | Prostate | BPH | 1.09e-31 | 6.53e-01 | 0.0972 |
222389 | BEND7 | 052099_1652-all-cells | Human | Prostate | BPH | 1.55e-13 | 4.71e-01 | 0.1038 |
222389 | BEND7 | Dong_P1 | Human | Prostate | Tumor | 9.12e-11 | 8.28e-02 | 0.035 |
222389 | BEND7 | male-WTA | Human | Thyroid | PTC | 6.65e-19 | 1.91e-02 | 0.1037 |
222389 | BEND7 | PTC01 | Human | Thyroid | PTC | 2.01e-11 | 2.49e-02 | 0.1899 |
222389 | BEND7 | PTC03 | Human | Thyroid | PTC | 5.24e-04 | 4.95e-02 | 0.1784 |
222389 | BEND7 | PTC04 | Human | Thyroid | PTC | 5.06e-17 | 3.18e-01 | 0.1927 |
222389 | BEND7 | PTC05 | Human | Thyroid | PTC | 1.14e-24 | 7.94e-01 | 0.2065 |
222389 | BEND7 | PTC06 | Human | Thyroid | PTC | 3.20e-31 | 7.12e-01 | 0.2057 |
222389 | BEND7 | PTC07 | Human | Thyroid | PTC | 9.34e-24 | 5.32e-01 | 0.2044 |
222389 | BEND7 | ATC09 | Human | Thyroid | ATC | 2.35e-05 | 1.15e-01 | 0.2871 |
222389 | BEND7 | ATC13 | Human | Thyroid | ATC | 4.57e-25 | 5.02e-01 | 0.34 |
222389 | BEND7 | ATC1 | Human | Thyroid | ATC | 3.01e-04 | 1.00e-01 | 0.2878 |
222389 | BEND7 | ATC5 | Human | Thyroid | ATC | 8.60e-25 | 5.59e-01 | 0.34 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Prostate | ![]() | BPH: Benign Prostatic Hyperplasia |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BEND7 | SNV | Missense_Mutation | novel | c.145N>A | p.Ser49Thr | p.S49T | Q8N7W2 | protein_coding | tolerated_low_confidence(0.25) | benign(0.015) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BEND7 | SNV | Missense_Mutation | c.1009N>T | p.Arg337Trp | p.R337W | Q8N7W2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.997) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BEND7 | SNV | Missense_Mutation | novel | c.1304C>A | p.Thr435Asn | p.T435N | Q8N7W2 | protein_coding | benign(0.367) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BEND7 | SNV | Missense_Mutation | c.376N>A | p.Glu126Lys | p.E126K | Q8N7W2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.991) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BEND7 | SNV | Missense_Mutation | novel | c.1000G>C | p.Ala334Pro | p.A334P | Q8N7W2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.998) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
BEND7 | SNV | Missense_Mutation | novel | c.1127N>T | p.Ala376Val | p.A376V | Q8N7W2 | protein_coding | deleterious_low_confidence(0.01) | benign(0.012) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
BEND7 | SNV | Missense_Mutation | rs201677598 | c.245G>A | p.Arg82His | p.R82H | Q8N7W2 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.996) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BEND7 | SNV | Missense_Mutation | c.508N>T | p.Pro170Ser | p.P170S | Q8N7W2 | protein_coding | deleterious_low_confidence(0.05) | benign(0.359) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BEND7 | SNV | Missense_Mutation | rs534620750 | c.58N>T | p.Arg20Trp | p.R20W | Q8N7W2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.997) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
BEND7 | SNV | Missense_Mutation | novel | c.1123G>A | p.Ala375Thr | p.A375T | Q8N7W2 | protein_coding | tolerated_low_confidence(0.45) | benign(0) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |