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Gene: BCLAF1 |
Gene summary for BCLAF1 |
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Gene information | Species | Human | Gene symbol | BCLAF1 | Gene ID | 9774 |
Gene name | BCL2 associated transcription factor 1 | |
Gene Alias | BTF | |
Cytomap | 6q23.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9NYF8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9774 | BCLAF1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.24e-16 | -6.36e-01 | 0.0155 |
9774 | BCLAF1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.17e-05 | -5.50e-01 | -0.1808 |
9774 | BCLAF1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.98e-07 | -6.38e-01 | -0.1207 |
9774 | BCLAF1 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.81e-16 | -4.51e-01 | -0.1464 |
9774 | BCLAF1 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.98e-16 | -5.08e-01 | -0.1001 |
9774 | BCLAF1 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.00e-09 | -5.58e-01 | 0.096 |
9774 | BCLAF1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 2.54e-02 | -7.12e-01 | 0.0451 |
9774 | BCLAF1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.81e-07 | -5.88e-01 | 0.0338 |
9774 | BCLAF1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 5.12e-04 | -5.67e-01 | 0.0588 |
9774 | BCLAF1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.67e-10 | -3.24e-01 | 0.294 |
9774 | BCLAF1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.31e-02 | 9.20e-01 | 0.3487 |
9774 | BCLAF1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.25e-06 | -3.65e-01 | 0.3859 |
9774 | BCLAF1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 7.53e-14 | -4.57e-01 | 0.3005 |
9774 | BCLAF1 | A015-C-203 | Human | Colorectum | FAP | 4.27e-24 | -1.70e-01 | -0.1294 |
9774 | BCLAF1 | A002-C-201 | Human | Colorectum | FAP | 3.33e-08 | -2.91e-01 | 0.0324 |
9774 | BCLAF1 | A002-C-203 | Human | Colorectum | FAP | 3.19e-03 | -1.10e-01 | 0.2786 |
9774 | BCLAF1 | A001-C-119 | Human | Colorectum | FAP | 3.51e-02 | 7.08e-02 | -0.1557 |
9774 | BCLAF1 | A001-C-108 | Human | Colorectum | FAP | 2.26e-12 | 1.32e-01 | -0.0272 |
9774 | BCLAF1 | A002-C-205 | Human | Colorectum | FAP | 2.86e-15 | -1.78e-03 | -0.1236 |
9774 | BCLAF1 | A001-C-104 | Human | Colorectum | FAP | 1.56e-02 | 7.36e-02 | 0.0184 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0097193 | Colorectum | AD | intrinsic apoptotic signaling pathway | 108/3918 | 288/18723 | 6.25e-11 | 6.41e-09 | 108 |
GO:2001242 | Colorectum | AD | regulation of intrinsic apoptotic signaling pathway | 67/3918 | 164/18723 | 4.94e-09 | 3.16e-07 | 67 |
GO:2001233 | Colorectum | AD | regulation of apoptotic signaling pathway | 119/3918 | 356/18723 | 2.14e-08 | 1.21e-06 | 119 |
GO:2001020 | Colorectum | AD | regulation of response to DNA damage stimulus | 71/3918 | 219/18723 | 4.38e-05 | 7.65e-04 | 71 |
GO:0043620 | Colorectum | AD | regulation of DNA-templated transcription in response to stress | 23/3918 | 53/18723 | 1.86e-04 | 2.49e-03 | 23 |
GO:2001235 | Colorectum | AD | positive regulation of apoptotic signaling pathway | 42/3918 | 126/18723 | 7.85e-04 | 7.84e-03 | 42 |
GO:2001244 | Colorectum | AD | positive regulation of intrinsic apoptotic signaling pathway | 23/3918 | 58/18723 | 8.82e-04 | 8.53e-03 | 23 |
GO:2001022 | Colorectum | AD | positive regulation of response to DNA damage stimulus | 36/3918 | 105/18723 | 1.02e-03 | 9.47e-03 | 36 |
GO:20012421 | Colorectum | SER | regulation of intrinsic apoptotic signaling pathway | 59/2897 | 164/18723 | 8.42e-11 | 1.20e-08 | 59 |
GO:00971931 | Colorectum | SER | intrinsic apoptotic signaling pathway | 87/2897 | 288/18723 | 1.67e-10 | 2.32e-08 | 87 |
GO:20012331 | Colorectum | SER | regulation of apoptotic signaling pathway | 101/2897 | 356/18723 | 3.05e-10 | 4.07e-08 | 101 |
GO:20012351 | Colorectum | SER | positive regulation of apoptotic signaling pathway | 36/2897 | 126/18723 | 1.29e-04 | 2.63e-03 | 36 |
GO:20012441 | Colorectum | SER | positive regulation of intrinsic apoptotic signaling pathway | 20/2897 | 58/18723 | 2.76e-04 | 4.59e-03 | 20 |
GO:00436201 | Colorectum | SER | regulation of DNA-templated transcription in response to stress | 17/2897 | 53/18723 | 1.93e-03 | 1.94e-02 | 17 |
GO:20010201 | Colorectum | SER | regulation of response to DNA damage stimulus | 49/2897 | 219/18723 | 4.24e-03 | 3.45e-02 | 49 |
GO:00971932 | Colorectum | MSS | intrinsic apoptotic signaling pathway | 102/3467 | 288/18723 | 6.06e-12 | 9.82e-10 | 102 |
GO:20012422 | Colorectum | MSS | regulation of intrinsic apoptotic signaling pathway | 66/3467 | 164/18723 | 6.70e-11 | 7.47e-09 | 66 |
GO:20012332 | Colorectum | MSS | regulation of apoptotic signaling pathway | 116/3467 | 356/18723 | 1.02e-10 | 1.06e-08 | 116 |
GO:20012352 | Colorectum | MSS | positive regulation of apoptotic signaling pathway | 42/3467 | 126/18723 | 4.95e-05 | 8.97e-04 | 42 |
GO:20010202 | Colorectum | MSS | regulation of response to DNA damage stimulus | 64/3467 | 219/18723 | 7.20e-05 | 1.21e-03 | 64 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
BCLAF1 | DUCT1 | Pancreas | Healthy | FTX,PNISR,SNHG14, etc. | 4.20e-01 | ![]() |
BCLAF1 | STM | Thyroid | HT | FUS,SFPQ,MT-ATP6, etc. | 6.93e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BCLAF1 | SNV | Missense_Mutation | c.489N>C | p.Glu163Asp | p.E163D | Q9NYF8 | protein_coding | tolerated_low_confidence(0.48) | benign(0.01) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
BCLAF1 | SNV | Missense_Mutation | c.836N>T | p.Asn279Ile | p.N279I | Q9NYF8 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
BCLAF1 | SNV | Missense_Mutation | c.685N>T | p.Pro229Ser | p.P229S | Q9NYF8 | protein_coding | tolerated(0.06) | probably_damaging(0.986) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
BCLAF1 | SNV | Missense_Mutation | novel | c.2489N>T | p.Pro830Leu | p.P830L | Q9NYF8 | protein_coding | deleterious(0.03) | probably_damaging(0.992) | TCGA-G4-6310-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fu | SD |
BCLAF1 | SNV | Missense_Mutation | c.2506N>C | p.Asp836His | p.D836H | Q9NYF8 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AG-3883-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
BCLAF1 | SNV | Missense_Mutation | rs755260641 | c.1129N>T | p.Asp377Tyr | p.D377Y | Q9NYF8 | protein_coding | deleterious(0) | possibly_damaging(0.447) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
BCLAF1 | SNV | Missense_Mutation | c.1473N>T | p.Lys491Asn | p.K491N | Q9NYF8 | protein_coding | deleterious(0.03) | probably_damaging(0.943) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
BCLAF1 | SNV | Missense_Mutation | c.2318N>A | p.Arg773Lys | p.R773K | Q9NYF8 | protein_coding | tolerated(0.43) | benign(0.173) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BCLAF1 | SNV | Missense_Mutation | c.838N>A | p.Gly280Arg | p.G280R | Q9NYF8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
BCLAF1 | SNV | Missense_Mutation | novel | c.658N>T | p.Asp220Tyr | p.D220Y | Q9NYF8 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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