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Gene: BCAS1 |
Gene summary for BCAS1 |
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Gene information | Species | Human | Gene symbol | BCAS1 | Gene ID | 8537 |
Gene name | brain enriched myelin associated protein 1 | |
Gene Alias | AIBC1 | |
Cytomap | 20q13.2 | |
Gene Type | protein-coding | GO ID | GO:0007272 | UniProtAcc | B2RCQ5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8537 | BCAS1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.30e-15 | 8.78e-01 | -0.1808 |
8537 | BCAS1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.86e-06 | 6.81e-01 | -0.0811 |
8537 | BCAS1 | HTA11_78_2000001011 | Human | Colorectum | AD | 5.06e-27 | 1.29e+00 | -0.1088 |
8537 | BCAS1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.40e-32 | 1.14e+00 | -0.1954 |
8537 | BCAS1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.02e-12 | 1.97e+00 | -0.2602 |
8537 | BCAS1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.17e-09 | 2.24e+00 | -0.2196 |
8537 | BCAS1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.13e-08 | 7.53e-01 | -0.1207 |
8537 | BCAS1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.43e-07 | 9.19e-01 | -0.1526 |
8537 | BCAS1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.82e-21 | 9.79e-01 | -0.1464 |
8537 | BCAS1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.86e-15 | 7.23e-01 | -0.1001 |
8537 | BCAS1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.07e-02 | 8.85e-01 | -0.1706 |
8537 | BCAS1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 9.27e-13 | 1.16e+00 | -0.2061 |
8537 | BCAS1 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.14e-03 | 6.04e-01 | -0.0842 |
8537 | BCAS1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.10e-06 | -3.32e-01 | 0.294 |
8537 | BCAS1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.94e-08 | -3.98e-01 | 0.3859 |
8537 | BCAS1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.28e-02 | -4.50e-01 | 0.2585 |
8537 | BCAS1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.72e-03 | -2.80e-01 | 0.3005 |
8537 | BCAS1 | A015-C-203 | Human | Colorectum | FAP | 1.65e-10 | -1.90e-01 | -0.1294 |
8537 | BCAS1 | A002-C-201 | Human | Colorectum | FAP | 4.99e-04 | -1.04e-01 | 0.0324 |
8537 | BCAS1 | A001-C-119 | Human | Colorectum | FAP | 2.39e-03 | -3.45e-01 | -0.1557 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00425524 | Esophagus | ESCC | myelination | 85/8552 | 134/18723 | 2.51e-05 | 2.13e-04 | 85 |
GO:00072724 | Esophagus | ESCC | ensheathment of neurons | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00083664 | Esophagus | ESCC | axon ensheathment | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00072721 | Liver | HCC | ensheathment of neurons | 72/7958 | 136/18723 | 8.87e-03 | 3.44e-02 | 72 |
GO:00083661 | Liver | HCC | axon ensheathment | 72/7958 | 136/18723 | 8.87e-03 | 3.44e-02 | 72 |
GO:00425521 | Liver | HCC | myelination | 71/7958 | 134/18723 | 9.08e-03 | 3.49e-02 | 71 |
GO:00425522 | Prostate | Tumor | myelination | 34/3246 | 134/18723 | 1.19e-02 | 4.85e-02 | 34 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BCAS1 | SNV | Missense_Mutation | novel | c.950N>A | p.Thr317Asn | p.T317N | O75363 | protein_coding | deleterious(0.01) | possibly_damaging(0.528) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BCAS1 | SNV | Missense_Mutation | rs147771144 | c.1690N>T | p.Arg564Trp | p.R564W | O75363 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BCAS1 | SNV | Missense_Mutation | rs752495014 | c.1037N>T | p.Ser346Leu | p.S346L | O75363 | protein_coding | tolerated(0.19) | benign(0.301) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
BCAS1 | SNV | Missense_Mutation | novel | c.824C>A | p.Ser275Tyr | p.S275Y | O75363 | protein_coding | deleterious(0) | benign(0.1) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
BCAS1 | SNV | Missense_Mutation | novel | c.1675N>T | p.Gly559Cys | p.G559C | O75363 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
BCAS1 | SNV | Missense_Mutation | novel | c.1492N>T | p.Gly498Cys | p.G498C | O75363 | protein_coding | deleterious(0.04) | possibly_damaging(0.81) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
BCAS1 | SNV | Missense_Mutation | novel | c.1235C>T | p.Ala412Val | p.A412V | O75363 | protein_coding | deleterious(0.01) | benign(0.436) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BCAS1 | SNV | Missense_Mutation | rs539868796 | c.1289C>T | p.Ala430Val | p.A430V | O75363 | protein_coding | tolerated(1) | benign(0) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BCAS1 | SNV | Missense_Mutation | rs762197510 | c.1499N>T | p.Ser500Leu | p.S500L | O75363 | protein_coding | deleterious(0.03) | possibly_damaging(0.683) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
BCAS1 | SNV | Missense_Mutation | c.856N>G | p.Ser286Ala | p.S286A | O75363 | protein_coding | deleterious(0.04) | benign(0.013) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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