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Gene: B3GNT7 |
Gene summary for B3GNT7 |
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Gene information | Species | Human | Gene symbol | B3GNT7 | Gene ID | 93010 |
Gene name | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 | |
Gene Alias | beta3GnT7 | |
Cytomap | 2q37.1 | |
Gene Type | protein-coding | GO ID | GO:0000271 | UniProtAcc | Q8NFL0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
93010 | B3GNT7 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.75e-02 | 3.60e-01 | -0.1808 |
93010 | B3GNT7 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.90e-69 | 1.95e+00 | -0.1954 |
93010 | B3GNT7 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.08e-12 | 2.84e+00 | -0.2602 |
93010 | B3GNT7 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.93e-07 | 1.14e+00 | -0.2196 |
93010 | B3GNT7 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.38e-28 | 1.17e+00 | -0.1464 |
93010 | B3GNT7 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.68e-12 | 5.32e-01 | -0.1001 |
93010 | B3GNT7 | HTA11_2992_2000001011 | Human | Colorectum | SER | 5.74e-25 | 2.42e+00 | -0.1706 |
93010 | B3GNT7 | HTA11_5212_2000001011 | Human | Colorectum | AD | 7.56e-37 | 2.86e+00 | -0.2061 |
93010 | B3GNT7 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.84e-07 | 1.03e+00 | -0.1462 |
93010 | B3GNT7 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.00e-02 | 5.18e-01 | -0.0842 |
93010 | B3GNT7 | HTA11_7862_2000001011 | Human | Colorectum | AD | 9.06e-37 | 2.00e+00 | -0.0179 |
93010 | B3GNT7 | HTA11_10623_2000001011 | Human | Colorectum | AD | 7.82e-03 | 4.75e-01 | -0.0177 |
93010 | B3GNT7 | LZE24T | Human | Esophagus | ESCC | 3.66e-13 | 4.83e-01 | 0.0596 |
93010 | B3GNT7 | P2T-E | Human | Esophagus | ESCC | 2.29e-02 | 4.98e-02 | 0.1177 |
93010 | B3GNT7 | P8T-E | Human | Esophagus | ESCC | 1.39e-32 | 8.44e-01 | 0.0889 |
93010 | B3GNT7 | P15T-E | Human | Esophagus | ESCC | 2.11e-03 | 1.85e-01 | 0.1149 |
93010 | B3GNT7 | P24T-E | Human | Esophagus | ESCC | 4.60e-02 | 4.35e-02 | 0.1287 |
93010 | B3GNT7 | P27T-E | Human | Esophagus | ESCC | 1.31e-07 | 8.02e-02 | 0.1055 |
93010 | B3GNT7 | P30T-E | Human | Esophagus | ESCC | 8.29e-05 | 3.00e-01 | 0.137 |
93010 | B3GNT7 | P31T-E | Human | Esophagus | ESCC | 1.28e-08 | 1.93e-01 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0044262 | Colorectum | AD | cellular carbohydrate metabolic process | 87/3918 | 283/18723 | 6.00e-05 | 1.01e-03 | 87 |
GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
GO:0006486 | Colorectum | AD | protein glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
GO:0043413 | Colorectum | AD | macromolecule glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
GO:0070085 | Colorectum | AD | glycosylation | 67/3918 | 240/18723 | 5.78e-03 | 3.67e-02 | 67 |
GO:00067901 | Colorectum | SER | sulfur compound metabolic process | 73/2897 | 339/18723 | 1.75e-03 | 1.81e-02 | 73 |
GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:00442725 | Esophagus | ESCC | sulfur compound biosynthetic process | 96/8552 | 148/18723 | 1.86e-06 | 2.16e-05 | 96 |
GO:00700854 | Esophagus | ESCC | glycosylation | 144/8552 | 240/18723 | 5.12e-06 | 5.38e-05 | 144 |
GO:00064865 | Esophagus | ESCC | protein glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00434135 | Esophagus | ESCC | macromolecule glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00091012 | Esophagus | ESCC | glycoprotein biosynthetic process | 181/8552 | 317/18723 | 2.54e-05 | 2.15e-04 | 181 |
GO:00442626 | Esophagus | ESCC | cellular carbohydrate metabolic process | 160/8552 | 283/18723 | 1.43e-04 | 9.66e-04 | 160 |
GO:00160514 | Esophagus | ESCC | carbohydrate biosynthetic process | 117/8552 | 202/18723 | 2.96e-04 | 1.79e-03 | 117 |
GO:00064931 | Esophagus | ESCC | protein O-linked glycosylation | 51/8552 | 86/18723 | 7.54e-03 | 2.70e-02 | 51 |
GO:0006024 | Esophagus | ESCC | glycosaminoglycan biosynthetic process | 45/8552 | 75/18723 | 8.75e-03 | 3.08e-02 | 45 |
GO:0006023 | Esophagus | ESCC | aminoglycan biosynthetic process | 47/8552 | 79/18723 | 9.29e-03 | 3.23e-02 | 47 |
GO:00346372 | Esophagus | ESCC | cellular carbohydrate biosynthetic process | 46/8552 | 78/18723 | 1.24e-02 | 4.13e-02 | 46 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
B3GNT7 | SNV | Missense_Mutation | novel | c.62N>T | p.Ala21Val | p.A21V | Q8NFL0 | protein_coding | deleterious(0.02) | benign(0.003) | TCGA-WX-AA46-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
B3GNT7 | SNV | Missense_Mutation | novel | c.586G>A | p.Glu196Lys | p.E196K | Q8NFL0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-8506-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
B3GNT7 | SNV | Missense_Mutation | c.496G>T | p.Gly166Trp | p.G166W | Q8NFL0 | protein_coding | deleterious(0.02) | possibly_damaging(0.708) | TCGA-55-8511-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
B3GNT7 | SNV | Missense_Mutation | c.141N>T | p.Lys47Asn | p.K47N | Q8NFL0 | protein_coding | tolerated(0.18) | benign(0.024) | TCGA-69-7979-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
B3GNT7 | SNV | Missense_Mutation | novel | c.285N>C | p.Leu95Phe | p.L95F | Q8NFL0 | protein_coding | tolerated(0.24) | benign(0.007) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
B3GNT7 | SNV | Missense_Mutation | novel | c.442G>A | p.Asp148Asn | p.D148N | Q8NFL0 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-85-8580-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
B3GNT7 | SNV | Missense_Mutation | novel | c.724G>C | p.Asp242His | p.D242H | Q8NFL0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-90-7964-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
B3GNT7 | SNV | Missense_Mutation | rs745834879 | c.116C>T | p.Pro39Leu | p.P39L | Q8NFL0 | protein_coding | tolerated(0.53) | benign(0) | TCGA-NK-A5CT-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
B3GNT7 | SNV | Missense_Mutation | rs769579473 | c.49N>A | p.Ala17Thr | p.A17T | Q8NFL0 | protein_coding | tolerated(0.33) | benign(0.024) | TCGA-BA-A4II-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
B3GNT7 | SNV | Missense_Mutation | c.208N>T | p.Ala70Ser | p.A70S | Q8NFL0 | protein_coding | tolerated(0.7) | benign(0.015) | TCGA-CR-6471-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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