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Gene: ATRAID |
Gene summary for ATRAID |
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Gene information | Species | Human | Gene symbol | ATRAID | Gene ID | 51374 |
Gene name | all-trans retinoic acid induced differentiation factor | |
Gene Alias | APR--3 | |
Cytomap | 2p23.3 | |
Gene Type | protein-coding | GO ID | GO:0001503 | UniProtAcc | Q6UW56 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51374 | ATRAID | CA_HPV_1 | Human | Cervix | CC | 3.06e-07 | -2.54e-01 | 0.0264 |
51374 | ATRAID | CA_HPV_3 | Human | Cervix | CC | 1.44e-02 | 2.04e-01 | 0.0414 |
51374 | ATRAID | CCI_1 | Human | Cervix | CC | 5.61e-04 | -5.22e-01 | 0.528 |
51374 | ATRAID | CCI_3 | Human | Cervix | CC | 8.70e-05 | -5.00e-01 | 0.516 |
51374 | ATRAID | CCII_1 | Human | Cervix | CC | 1.41e-10 | -5.40e-01 | 0.3249 |
51374 | ATRAID | sample3 | Human | Cervix | CC | 9.96e-03 | 2.68e-02 | 0.1387 |
51374 | ATRAID | L1 | Human | Cervix | CC | 6.61e-04 | -2.90e-01 | 0.0802 |
51374 | ATRAID | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.57e-08 | 2.85e-01 | 0.0155 |
51374 | ATRAID | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.22e-07 | 4.16e-01 | -0.1808 |
51374 | ATRAID | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.05e-06 | 4.88e-01 | -0.0811 |
51374 | ATRAID | HTA11_78_2000001011 | Human | Colorectum | AD | 5.88e-03 | 2.59e-01 | -0.1088 |
51374 | ATRAID | HTA11_347_2000001011 | Human | Colorectum | AD | 6.41e-19 | 5.32e-01 | -0.1954 |
51374 | ATRAID | HTA11_696_2000001011 | Human | Colorectum | AD | 1.60e-14 | 4.15e-01 | -0.1464 |
51374 | ATRAID | HTA11_866_2000001011 | Human | Colorectum | AD | 2.07e-08 | 2.80e-01 | -0.1001 |
51374 | ATRAID | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.12e-14 | 4.95e-01 | -0.059 |
51374 | ATRAID | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.58e-06 | 5.27e-01 | -0.1706 |
51374 | ATRAID | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.31e-05 | 5.46e-01 | -0.2061 |
51374 | ATRAID | HTA11_5216_2000001011 | Human | Colorectum | SER | 7.70e-03 | 5.69e-01 | -0.1462 |
51374 | ATRAID | HTA11_546_2000001011 | Human | Colorectum | AD | 3.98e-10 | 5.04e-01 | -0.0842 |
51374 | ATRAID | HTA11_7862_2000001011 | Human | Colorectum | AD | 8.82e-05 | 4.13e-01 | -0.0179 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004217610 | Cervix | CC | regulation of protein catabolic process | 104/2311 | 391/18723 | 9.39e-15 | 9.36e-12 | 104 |
GO:190336210 | Cervix | CC | regulation of cellular protein catabolic process | 72/2311 | 255/18723 | 5.98e-12 | 2.10e-09 | 72 |
GO:003133010 | Cervix | CC | negative regulation of cellular catabolic process | 63/2311 | 262/18723 | 1.10e-07 | 5.68e-06 | 63 |
GO:000989510 | Cervix | CC | negative regulation of catabolic process | 69/2311 | 320/18723 | 2.15e-06 | 6.55e-05 | 69 |
GO:19033639 | Cervix | CC | negative regulation of cellular protein catabolic process | 24/2311 | 75/18723 | 6.43e-06 | 1.55e-04 | 24 |
GO:004217710 | Cervix | CC | negative regulation of protein catabolic process | 30/2311 | 121/18723 | 1.23e-04 | 1.53e-03 | 30 |
GO:00016497 | Cervix | CC | osteoblast differentiation | 47/2311 | 229/18723 | 2.88e-04 | 3.11e-03 | 47 |
GO:0045667 | Cervix | CC | regulation of osteoblast differentiation | 29/2311 | 132/18723 | 1.32e-03 | 1.05e-02 | 29 |
GO:00015037 | Cervix | CC | ossification | 71/2311 | 408/18723 | 1.67e-03 | 1.28e-02 | 71 |
GO:0033688 | Cervix | CC | regulation of osteoblast proliferation | 9/2311 | 27/18723 | 3.82e-03 | 2.41e-02 | 9 |
GO:0033687 | Cervix | CC | osteoblast proliferation | 10/2311 | 32/18723 | 3.96e-03 | 2.48e-02 | 10 |
GO:00302781 | Cervix | CC | regulation of ossification | 24/2311 | 115/18723 | 6.51e-03 | 3.61e-02 | 24 |
GO:0030501 | Cervix | CC | positive regulation of bone mineralization | 11/2311 | 40/18723 | 7.54e-03 | 4.02e-02 | 11 |
GO:0031214 | Cervix | CC | biomineral tissue development | 32/2311 | 169/18723 | 8.73e-03 | 4.48e-02 | 32 |
GO:0045669 | Cervix | CC | positive regulation of osteoblast differentiation | 16/2311 | 69/18723 | 8.75e-03 | 4.48e-02 | 16 |
GO:0030282 | Cervix | CC | bone mineralization | 24/2311 | 119/18723 | 1.00e-02 | 4.89e-02 | 24 |
GO:0110148 | Cervix | CC | biomineralization | 32/2311 | 171/18723 | 1.04e-02 | 4.97e-02 | 32 |
GO:0042176 | Colorectum | AD | regulation of protein catabolic process | 160/3918 | 391/18723 | 1.06e-19 | 7.34e-17 | 160 |
GO:1903362 | Colorectum | AD | regulation of cellular protein catabolic process | 109/3918 | 255/18723 | 2.14e-15 | 6.08e-13 | 109 |
GO:0009895 | Colorectum | AD | negative regulation of catabolic process | 124/3918 | 320/18723 | 1.66e-13 | 3.35e-11 | 124 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATRAID | SNV | Missense_Mutation | c.661N>T | p.Pro221Ser | p.P221S | Q6UW56 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-22-5491-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ATRAID | SNV | Missense_Mutation | novel | c.267N>G | p.Ile89Met | p.I89M | Q6UW56 | protein_coding | deleterious(0) | possibly_damaging(0.829) | TCGA-68-7757-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ATRAID | SNV | Missense_Mutation | novel | c.580A>G | p.Thr194Ala | p.T194A | Q6UW56 | protein_coding | tolerated(0.22) | benign(0.194) | TCGA-CN-5360-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD |
ATRAID | SNV | Missense_Mutation | c.460G>T | p.Asp154Tyr | p.D154Y | Q6UW56 | protein_coding | deleterious(0.02) | probably_damaging(0.967) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ATRAID | SNV | Missense_Mutation | c.754T>C | p.Ser252Pro | p.S252P | Q6UW56 | protein_coding | tolerated(0.06) | probably_damaging(0.952) | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ATRAID | deletion | Frame_Shift_Del | novel | c.306delA | p.Val103TrpfsTer11 | p.V103Wfs*11 | Q6UW56 | protein_coding | TCGA-CG-4465-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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