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Gene: ATP2B1 |
Gene summary for ATP2B1 |
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Gene information | Species | Human | Gene symbol | ATP2B1 | Gene ID | 490 |
Gene name | ATPase plasma membrane Ca2+ transporting 1 | |
Gene Alias | PMCA1 | |
Cytomap | 12q21.33 | |
Gene Type | protein-coding | GO ID | GO:0001503 | UniProtAcc | P20020 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
490 | ATP2B1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.66e-10 | -5.06e-01 | 0.0155 |
490 | ATP2B1 | HTA11_347_2000001011 | Human | Colorectum | AD | 9.26e-04 | 3.83e-01 | -0.1954 |
490 | ATP2B1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.43e-05 | -4.62e-01 | 0.096 |
490 | ATP2B1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.50e-03 | -4.78e-01 | 0.0338 |
490 | ATP2B1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.84e-10 | -3.97e-01 | 0.0674 |
490 | ATP2B1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.29e-23 | -6.11e-01 | 0.3005 |
490 | ATP2B1 | F007 | Human | Colorectum | FAP | 3.31e-02 | -3.57e-01 | 0.1176 |
490 | ATP2B1 | A002-C-010 | Human | Colorectum | FAP | 1.48e-05 | -3.30e-01 | 0.242 |
490 | ATP2B1 | A001-C-207 | Human | Colorectum | FAP | 2.44e-05 | -3.54e-01 | 0.1278 |
490 | ATP2B1 | A015-C-203 | Human | Colorectum | FAP | 2.92e-27 | -4.74e-01 | -0.1294 |
490 | ATP2B1 | A015-C-204 | Human | Colorectum | FAP | 4.30e-03 | -2.75e-01 | -0.0228 |
490 | ATP2B1 | A014-C-040 | Human | Colorectum | FAP | 1.07e-03 | -4.92e-01 | -0.1184 |
490 | ATP2B1 | A002-C-201 | Human | Colorectum | FAP | 7.38e-13 | -4.49e-01 | 0.0324 |
490 | ATP2B1 | A002-C-203 | Human | Colorectum | FAP | 4.34e-13 | -3.97e-01 | 0.2786 |
490 | ATP2B1 | A001-C-119 | Human | Colorectum | FAP | 2.90e-07 | -5.23e-01 | -0.1557 |
490 | ATP2B1 | A001-C-108 | Human | Colorectum | FAP | 1.37e-16 | -3.93e-01 | -0.0272 |
490 | ATP2B1 | A002-C-205 | Human | Colorectum | FAP | 1.47e-17 | -4.84e-01 | -0.1236 |
490 | ATP2B1 | A001-C-104 | Human | Colorectum | FAP | 9.36e-06 | -2.44e-01 | 0.0184 |
490 | ATP2B1 | A015-C-005 | Human | Colorectum | FAP | 4.03e-05 | -4.06e-01 | -0.0336 |
490 | ATP2B1 | A015-C-006 | Human | Colorectum | FAP | 6.51e-11 | -3.75e-01 | -0.0994 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0032868 | Colorectum | AD | response to insulin | 91/3918 | 264/18723 | 2.02e-07 | 8.48e-06 | 91 |
GO:0071383 | Colorectum | AD | cellular response to steroid hormone stimulus | 73/3918 | 204/18723 | 6.31e-07 | 2.24e-05 | 73 |
GO:1901653 | Colorectum | AD | cellular response to peptide | 114/3918 | 359/18723 | 8.32e-07 | 2.88e-05 | 114 |
GO:0032869 | Colorectum | AD | cellular response to insulin stimulus | 72/3918 | 203/18723 | 1.10e-06 | 3.68e-05 | 72 |
GO:0071375 | Colorectum | AD | cellular response to peptide hormone stimulus | 95/3918 | 290/18723 | 1.50e-06 | 4.66e-05 | 95 |
GO:0043434 | Colorectum | AD | response to peptide hormone | 126/3918 | 414/18723 | 2.70e-06 | 7.86e-05 | 126 |
GO:0031667 | Colorectum | AD | response to nutrient levels | 138/3918 | 474/18723 | 1.22e-05 | 2.68e-04 | 138 |
GO:0048545 | Colorectum | AD | response to steroid hormone | 104/3918 | 339/18723 | 1.33e-05 | 2.90e-04 | 104 |
GO:0060249 | Colorectum | AD | anatomical structure homeostasis | 94/3918 | 314/18723 | 9.37e-05 | 1.42e-03 | 94 |
GO:0009409 | Colorectum | AD | response to cold | 22/3918 | 49/18723 | 1.40e-04 | 1.98e-03 | 22 |
GO:0071496 | Colorectum | AD | cellular response to external stimulus | 94/3918 | 320/18723 | 1.98e-04 | 2.64e-03 | 94 |
GO:0007568 | Colorectum | AD | aging | 98/3918 | 339/18723 | 2.77e-04 | 3.39e-03 | 98 |
GO:1901654 | Colorectum | AD | response to ketone | 59/3918 | 194/18723 | 1.14e-03 | 1.04e-02 | 59 |
GO:0090257 | Colorectum | AD | regulation of muscle system process | 73/3918 | 252/18723 | 1.46e-03 | 1.24e-02 | 73 |
GO:0031668 | Colorectum | AD | cellular response to extracellular stimulus | 71/3918 | 246/18723 | 1.86e-03 | 1.52e-02 | 71 |
GO:0031669 | Colorectum | AD | cellular response to nutrient levels | 63/3918 | 215/18723 | 2.19e-03 | 1.73e-02 | 63 |
GO:0097305 | Colorectum | AD | response to alcohol | 71/3918 | 253/18723 | 4.01e-03 | 2.80e-02 | 71 |
GO:0001503 | Colorectum | AD | ossification | 106/3918 | 408/18723 | 7.68e-03 | 4.64e-02 | 106 |
GO:00713832 | Colorectum | MSS | cellular response to steroid hormone stimulus | 72/3467 | 204/18723 | 8.87e-09 | 5.43e-07 | 72 |
GO:00485452 | Colorectum | MSS | response to steroid hormone | 101/3467 | 339/18723 | 2.60e-07 | 1.10e-05 | 101 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04961 | Colorectum | AD | Endocrine and other factor-regulated calcium reabsorption | 24/2092 | 53/8465 | 8.49e-04 | 5.93e-03 | 3.78e-03 | 24 |
hsa04972 | Colorectum | AD | Pancreatic secretion | 36/2092 | 102/8465 | 1.06e-02 | 3.98e-02 | 2.54e-02 | 36 |
hsa049611 | Colorectum | AD | Endocrine and other factor-regulated calcium reabsorption | 24/2092 | 53/8465 | 8.49e-04 | 5.93e-03 | 3.78e-03 | 24 |
hsa049721 | Colorectum | AD | Pancreatic secretion | 36/2092 | 102/8465 | 1.06e-02 | 3.98e-02 | 2.54e-02 | 36 |
hsa049614 | Colorectum | MSS | Endocrine and other factor-regulated calcium reabsorption | 24/1875 | 53/8465 | 1.49e-04 | 1.24e-03 | 7.61e-04 | 24 |
hsa049724 | Colorectum | MSS | Pancreatic secretion | 33/1875 | 102/8465 | 1.09e-02 | 3.75e-02 | 2.30e-02 | 33 |
hsa049615 | Colorectum | MSS | Endocrine and other factor-regulated calcium reabsorption | 24/1875 | 53/8465 | 1.49e-04 | 1.24e-03 | 7.61e-04 | 24 |
hsa049725 | Colorectum | MSS | Pancreatic secretion | 33/1875 | 102/8465 | 1.09e-02 | 3.75e-02 | 2.30e-02 | 33 |
hsa049726 | Colorectum | FAP | Pancreatic secretion | 34/1404 | 102/8465 | 2.43e-05 | 2.78e-04 | 1.69e-04 | 34 |
hsa049616 | Colorectum | FAP | Endocrine and other factor-regulated calcium reabsorption | 18/1404 | 53/8465 | 1.52e-03 | 7.94e-03 | 4.83e-03 | 18 |
hsa040222 | Colorectum | FAP | cGMP-PKG signaling pathway | 42/1404 | 167/8465 | 2.84e-03 | 1.27e-02 | 7.70e-03 | 42 |
hsa04261 | Colorectum | FAP | Adrenergic signaling in cardiomyocytes | 38/1404 | 154/8465 | 6.16e-03 | 2.34e-02 | 1.42e-02 | 38 |
hsa04024 | Colorectum | FAP | cAMP signaling pathway | 51/1404 | 225/8465 | 1.02e-02 | 3.68e-02 | 2.24e-02 | 51 |
hsa04970 | Colorectum | FAP | Salivary secretion | 24/1404 | 93/8465 | 1.52e-02 | 4.99e-02 | 3.03e-02 | 24 |
hsa04925 | Colorectum | FAP | Aldosterone synthesis and secretion | 25/1404 | 98/8465 | 1.55e-02 | 4.99e-02 | 3.04e-02 | 25 |
hsa049727 | Colorectum | FAP | Pancreatic secretion | 34/1404 | 102/8465 | 2.43e-05 | 2.78e-04 | 1.69e-04 | 34 |
hsa049617 | Colorectum | FAP | Endocrine and other factor-regulated calcium reabsorption | 18/1404 | 53/8465 | 1.52e-03 | 7.94e-03 | 4.83e-03 | 18 |
hsa040223 | Colorectum | FAP | cGMP-PKG signaling pathway | 42/1404 | 167/8465 | 2.84e-03 | 1.27e-02 | 7.70e-03 | 42 |
hsa042611 | Colorectum | FAP | Adrenergic signaling in cardiomyocytes | 38/1404 | 154/8465 | 6.16e-03 | 2.34e-02 | 1.42e-02 | 38 |
hsa040241 | Colorectum | FAP | cAMP signaling pathway | 51/1404 | 225/8465 | 1.02e-02 | 3.68e-02 | 2.24e-02 | 51 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP2B1 | SNV | Missense_Mutation | c.1891N>A | p.Asp631Asn | p.D631N | P20020 | protein_coding | tolerated(0.21) | possibly_damaging(0.797) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
ATP2B1 | SNV | Missense_Mutation | novel | c.2365N>T | p.Arg789Cys | p.R789C | P20020 | protein_coding | deleterious(0) | possibly_damaging(0.781) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ATP2B1 | SNV | Missense_Mutation | c.2091T>G | p.Cys697Trp | p.C697W | P20020 | protein_coding | deleterious(0) | possibly_damaging(0.88) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ATP2B1 | SNV | Missense_Mutation | c.712N>C | p.Ile238Leu | p.I238L | P20020 | protein_coding | tolerated(0.11) | benign(0.28) | TCGA-VS-A9V0-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
ATP2B1 | SNV | Missense_Mutation | novel | c.3176N>T | p.Ser1059Leu | p.S1059L | P20020 | protein_coding | tolerated(0.19) | benign(0.154) | TCGA-ZJ-AAXU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ATP2B1 | SNV | Missense_Mutation | novel | c.3276G>T | p.Glu1092Asp | p.E1092D | P20020 | protein_coding | tolerated(0.18) | benign(0.107) | TCGA-AA-3831-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ATP2B1 | SNV | Missense_Mutation | novel | c.2036N>C | p.Val679Ala | p.V679A | P20020 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATP2B1 | SNV | Missense_Mutation | c.3419N>T | p.Ser1140Leu | p.S1140L | P20020 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.99) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ATP2B1 | SNV | Missense_Mutation | c.3130N>C | p.Ser1044Pro | p.S1044P | P20020 | protein_coding | deleterious(0) | possibly_damaging(0.564) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ATP2B1 | SNV | Missense_Mutation | novel | c.2990N>T | p.Arg997Ile | p.R997I | P20020 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
490 | ATP2B1 | DRUGGABLE GENOME, TRANSPORTER, ENZYME | Antihypertensives | 25385345 |
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