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Gene: ATP13A1 |
Gene summary for ATP13A1 |
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Gene information | Species | Human | Gene symbol | ATP13A1 | Gene ID | 57130 |
Gene name | ATPase 13A1 | |
Gene Alias | ATP13A | |
Cytomap | 19p13.11 | |
Gene Type | protein-coding | GO ID | GO:0000041 | UniProtAcc | A0A024R7N2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57130 | ATP13A1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.08e-02 | 7.27e-02 | 0.0155 |
57130 | ATP13A1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 9.84e-04 | 2.24e-01 | -0.1808 |
57130 | ATP13A1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.42e-03 | 1.15e-01 | -0.1954 |
57130 | ATP13A1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.68e-03 | 1.98e-01 | -0.059 |
57130 | ATP13A1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.51e-09 | 1.72e-01 | 0.0674 |
57130 | ATP13A1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.87e-02 | 1.25e-01 | 0.294 |
57130 | ATP13A1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.69e-04 | 2.35e-01 | 0.3859 |
57130 | ATP13A1 | LZE7T | Human | Esophagus | ESCC | 2.28e-11 | 3.97e-01 | 0.0667 |
57130 | ATP13A1 | LZE24T | Human | Esophagus | ESCC | 2.09e-16 | 3.64e-01 | 0.0596 |
57130 | ATP13A1 | P1T-E | Human | Esophagus | ESCC | 2.75e-10 | 2.97e-01 | 0.0875 |
57130 | ATP13A1 | P2T-E | Human | Esophagus | ESCC | 5.08e-10 | 1.61e-01 | 0.1177 |
57130 | ATP13A1 | P4T-E | Human | Esophagus | ESCC | 7.88e-12 | 2.58e-01 | 0.1323 |
57130 | ATP13A1 | P5T-E | Human | Esophagus | ESCC | 8.19e-12 | 1.38e-01 | 0.1327 |
57130 | ATP13A1 | P8T-E | Human | Esophagus | ESCC | 1.19e-16 | 3.67e-01 | 0.0889 |
57130 | ATP13A1 | P9T-E | Human | Esophagus | ESCC | 5.17e-16 | 3.05e-01 | 0.1131 |
57130 | ATP13A1 | P10T-E | Human | Esophagus | ESCC | 2.35e-18 | 3.60e-01 | 0.116 |
57130 | ATP13A1 | P11T-E | Human | Esophagus | ESCC | 1.82e-18 | 5.97e-01 | 0.1426 |
57130 | ATP13A1 | P12T-E | Human | Esophagus | ESCC | 7.28e-26 | 3.43e-01 | 0.1122 |
57130 | ATP13A1 | P15T-E | Human | Esophagus | ESCC | 1.48e-15 | 3.13e-01 | 0.1149 |
57130 | ATP13A1 | P16T-E | Human | Esophagus | ESCC | 2.74e-23 | 4.11e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
GO:0071421 | Colorectum | AD | manganese ion transmembrane transport | 6/3918 | 10/18723 | 8.03e-03 | 4.73e-02 | 6 |
GO:00901501 | Colorectum | SER | establishment of protein localization to membrane | 68/2897 | 260/18723 | 5.55e-06 | 2.01e-04 | 68 |
GO:00901502 | Colorectum | MSS | establishment of protein localization to membrane | 90/3467 | 260/18723 | 4.11e-10 | 3.49e-08 | 90 |
GO:0090150110 | Esophagus | ESCC | establishment of protein localization to membrane | 182/8552 | 260/18723 | 1.27e-15 | 8.19e-14 | 182 |
GO:00901507 | Liver | Cirrhotic | establishment of protein localization to membrane | 123/4634 | 260/18723 | 1.85e-15 | 2.15e-13 | 123 |
GO:009015012 | Liver | HCC | establishment of protein localization to membrane | 168/7958 | 260/18723 | 4.07e-13 | 2.13e-11 | 168 |
GO:00000411 | Liver | HCC | transition metal ion transport | 59/7958 | 105/18723 | 3.18e-03 | 1.47e-02 | 59 |
GO:009015018 | Oral cavity | OSCC | establishment of protein localization to membrane | 163/7305 | 260/18723 | 7.13e-15 | 4.47e-13 | 163 |
GO:009015019 | Oral cavity | LP | establishment of protein localization to membrane | 128/4623 | 260/18723 | 7.19e-18 | 1.19e-15 | 128 |
GO:0090150112 | Thyroid | PTC | establishment of protein localization to membrane | 149/5968 | 260/18723 | 1.64e-17 | 1.59e-15 | 149 |
GO:009015031 | Thyroid | ATC | establishment of protein localization to membrane | 150/6293 | 260/18723 | 1.05e-15 | 7.96e-14 | 150 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP13A1 | SNV | Missense_Mutation | c.2053N>A | p.Val685Ile | p.V685I | Q9HD20 | protein_coding | deleterious(0.04) | possibly_damaging(0.745) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ATP13A1 | SNV | Missense_Mutation | rs762199597 | c.2674N>T | p.Arg892Trp | p.R892W | Q9HD20 | protein_coding | deleterious(0.01) | possibly_damaging(0.821) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP13A1 | SNV | Missense_Mutation | novel | c.3281T>C | p.Phe1094Ser | p.F1094S | Q9HD20 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP13A1 | SNV | Missense_Mutation | novel | c.595G>A | p.Ala199Thr | p.A199T | Q9HD20 | protein_coding | tolerated(0.65) | benign(0.003) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ATP13A1 | SNV | Missense_Mutation | rs780602859 | c.2224C>T | p.Arg742Trp | p.R742W | Q9HD20 | protein_coding | deleterious(0.02) | probably_damaging(0.98) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP13A1 | SNV | Missense_Mutation | c.2190N>T | p.Lys730Asn | p.K730N | Q9HD20 | protein_coding | deleterious(0.03) | possibly_damaging(0.487) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ATP13A1 | SNV | Missense_Mutation | c.3235C>T | p.Arg1079Trp | p.R1079W | Q9HD20 | protein_coding | tolerated(0.18) | possibly_damaging(0.786) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ATP13A1 | SNV | Missense_Mutation | rs774291606 | c.2486N>A | p.Arg829His | p.R829H | Q9HD20 | protein_coding | tolerated(0.11) | benign(0.046) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATP13A1 | SNV | Missense_Mutation | c.1790N>T | p.Ala597Val | p.A597V | Q9HD20 | protein_coding | deleterious(0.02) | possibly_damaging(0.771) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ATP13A1 | SNV | Missense_Mutation | c.3206N>G | p.Leu1069Arg | p.L1069R | Q9HD20 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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