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Gene: ASCC2 |
Gene summary for ASCC2 |
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Gene information | Species | Human | Gene symbol | ASCC2 | Gene ID | 84164 |
Gene name | activating signal cointegrator 1 complex subunit 2 | |
Gene Alias | ASC1p100 | |
Cytomap | 22q12.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9H1I8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84164 | ASCC2 | LZE4T | Human | Esophagus | ESCC | 3.19e-13 | 3.61e-01 | 0.0811 |
84164 | ASCC2 | LZE7T | Human | Esophagus | ESCC | 9.40e-09 | 4.73e-01 | 0.0667 |
84164 | ASCC2 | LZE8T | Human | Esophagus | ESCC | 4.85e-07 | 1.81e-01 | 0.067 |
84164 | ASCC2 | LZE20T | Human | Esophagus | ESCC | 2.87e-08 | 3.08e-01 | 0.0662 |
84164 | ASCC2 | LZE21D1 | Human | Esophagus | HGIN | 1.59e-02 | 3.00e-01 | 0.0632 |
84164 | ASCC2 | LZE22D1 | Human | Esophagus | HGIN | 1.34e-06 | 2.98e-01 | 0.0595 |
84164 | ASCC2 | LZE22T | Human | Esophagus | ESCC | 3.76e-08 | 4.52e-01 | 0.068 |
84164 | ASCC2 | LZE24T | Human | Esophagus | ESCC | 2.52e-24 | 6.31e-01 | 0.0596 |
84164 | ASCC2 | LZE21T | Human | Esophagus | ESCC | 5.18e-10 | 6.12e-01 | 0.0655 |
84164 | ASCC2 | P1T-E | Human | Esophagus | ESCC | 2.93e-17 | 6.61e-01 | 0.0875 |
84164 | ASCC2 | P2T-E | Human | Esophagus | ESCC | 9.65e-32 | 3.95e-01 | 0.1177 |
84164 | ASCC2 | P4T-E | Human | Esophagus | ESCC | 3.10e-26 | 6.29e-01 | 0.1323 |
84164 | ASCC2 | P5T-E | Human | Esophagus | ESCC | 3.64e-17 | 1.63e-01 | 0.1327 |
84164 | ASCC2 | P8T-E | Human | Esophagus | ESCC | 1.15e-37 | 6.61e-01 | 0.0889 |
84164 | ASCC2 | P9T-E | Human | Esophagus | ESCC | 1.31e-13 | 3.11e-01 | 0.1131 |
84164 | ASCC2 | P10T-E | Human | Esophagus | ESCC | 2.51e-43 | 6.96e-01 | 0.116 |
84164 | ASCC2 | P11T-E | Human | Esophagus | ESCC | 1.96e-15 | 6.95e-01 | 0.1426 |
84164 | ASCC2 | P12T-E | Human | Esophagus | ESCC | 2.79e-22 | 4.34e-01 | 0.1122 |
84164 | ASCC2 | P15T-E | Human | Esophagus | ESCC | 8.44e-33 | 6.75e-01 | 0.1149 |
84164 | ASCC2 | P16T-E | Human | Esophagus | ESCC | 8.08e-26 | 5.05e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000641727 | Esophagus | HGIN | regulation of translation | 139/2587 | 468/18723 | 1.46e-19 | 7.98e-17 | 139 |
GO:001049826 | Esophagus | HGIN | proteasomal protein catabolic process | 139/2587 | 490/18723 | 1.20e-17 | 3.41e-15 | 139 |
GO:004316126 | Esophagus | HGIN | proteasome-mediated ubiquitin-dependent protein catabolic process | 114/2587 | 412/18723 | 7.00e-14 | 1.20e-11 | 114 |
GO:000641418 | Esophagus | HGIN | translational elongation | 22/2587 | 55/18723 | 1.46e-06 | 5.56e-05 | 22 |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0043161111 | Esophagus | ESCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 312/8552 | 412/18723 | 3.53e-36 | 4.48e-33 | 312 |
GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
GO:000641419 | Esophagus | ESCC | translational elongation | 41/8552 | 55/18723 | 1.26e-05 | 1.16e-04 | 41 |
GO:00431617 | Liver | NAFLD | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/1882 | 412/18723 | 3.00e-13 | 1.75e-10 | 91 |
GO:00104987 | Liver | NAFLD | proteasomal protein catabolic process | 101/1882 | 490/18723 | 1.35e-12 | 6.09e-10 | 101 |
GO:00064177 | Liver | NAFLD | regulation of translation | 85/1882 | 468/18723 | 4.58e-08 | 4.54e-06 | 85 |
GO:00064145 | Liver | NAFLD | translational elongation | 16/1882 | 55/18723 | 6.71e-05 | 1.44e-03 | 16 |
GO:001049812 | Liver | Cirrhotic | proteasomal protein catabolic process | 216/4634 | 490/18723 | 2.52e-21 | 9.29e-19 | 216 |
GO:004316112 | Liver | Cirrhotic | proteasome-mediated ubiquitin-dependent protein catabolic process | 184/4634 | 412/18723 | 4.52e-19 | 8.85e-17 | 184 |
GO:000641712 | Liver | Cirrhotic | regulation of translation | 194/4634 | 468/18723 | 7.28e-16 | 8.79e-14 | 194 |
GO:001049822 | Liver | HCC | proteasomal protein catabolic process | 351/7958 | 490/18723 | 6.92e-40 | 1.46e-36 | 351 |
GO:004316122 | Liver | HCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 299/7958 | 412/18723 | 7.82e-36 | 8.27e-33 | 299 |
GO:000641722 | Liver | HCC | regulation of translation | 287/7958 | 468/18723 | 8.79e-17 | 8.08e-15 | 287 |
GO:000641412 | Liver | HCC | translational elongation | 36/7958 | 55/18723 | 4.94e-04 | 3.23e-03 | 36 |
GO:001049820 | Oral cavity | OSCC | proteasomal protein catabolic process | 336/7305 | 490/18723 | 5.45e-41 | 8.63e-38 | 336 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ASCC2 | SNV | Missense_Mutation | novel | c.1406N>G | p.Asp469Gly | p.D469G | Q9H1I8 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ASCC2 | SNV | Missense_Mutation | novel | c.1610N>T | p.His537Leu | p.H537L | Q9H1I8 | protein_coding | tolerated(0.64) | benign(0.001) | TCGA-AG-3909-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR |
ASCC2 | SNV | Missense_Mutation | novel | c.1658N>G | p.Val553Gly | p.V553G | Q9H1I8 | protein_coding | deleterious(0) | probably_damaging(0.927) | TCGA-AG-A025-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ASCC2 | insertion | Frame_Shift_Ins | novel | c.315_316insATCA | p.Val106IlefsTer7 | p.V106Ifs*7 | Q9H1I8 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ASCC2 | SNV | Missense_Mutation | novel | c.1640T>C | p.Val547Ala | p.V547A | Q9H1I8 | protein_coding | deleterious(0) | possibly_damaging(0.853) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ASCC2 | SNV | Missense_Mutation | rs779333751 | c.496N>A | p.Val166Met | p.V166M | Q9H1I8 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ASCC2 | SNV | Missense_Mutation | novel | c.739C>A | p.Leu247Ile | p.L247I | Q9H1I8 | protein_coding | tolerated(0.05) | probably_damaging(0.955) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ASCC2 | SNV | Missense_Mutation | novel | c.1680N>T | p.Lys560Asn | p.K560N | Q9H1I8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ASCC2 | SNV | Missense_Mutation | novel | c.191N>T | p.Asn64Ile | p.N64I | Q9H1I8 | protein_coding | deleterious(0.03) | benign(0.445) | TCGA-AP-A1DO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ASCC2 | SNV | Missense_Mutation | novel | c.1646N>A | p.Ser549Asn | p.S549N | Q9H1I8 | protein_coding | tolerated(0.23) | benign(0.105) | TCGA-AX-A063-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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