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Gene: ASB13 |
Gene summary for ASB13 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ASB13 | Gene ID | 79754 |
Gene name | ankyrin repeat and SOCS box containing 13 | |
Gene Alias | ASB13 | |
Cytomap | 10p15.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8WXK3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79754 | ASB13 | P2T-E | Human | Esophagus | ESCC | 2.96e-07 | 1.86e-01 | 0.1177 |
79754 | ASB13 | P5T-E | Human | Esophagus | ESCC | 1.22e-05 | 1.10e-01 | 0.1327 |
79754 | ASB13 | P8T-E | Human | Esophagus | ESCC | 8.36e-12 | 8.23e-02 | 0.0889 |
79754 | ASB13 | P10T-E | Human | Esophagus | ESCC | 9.88e-06 | 6.33e-02 | 0.116 |
79754 | ASB13 | P12T-E | Human | Esophagus | ESCC | 2.23e-03 | 9.56e-02 | 0.1122 |
79754 | ASB13 | P15T-E | Human | Esophagus | ESCC | 9.68e-06 | 1.23e-01 | 0.1149 |
79754 | ASB13 | P16T-E | Human | Esophagus | ESCC | 6.18e-15 | 2.52e-01 | 0.1153 |
79754 | ASB13 | P17T-E | Human | Esophagus | ESCC | 8.40e-07 | 2.83e-01 | 0.1278 |
79754 | ASB13 | P19T-E | Human | Esophagus | ESCC | 1.04e-02 | 3.59e-01 | 0.1662 |
79754 | ASB13 | P20T-E | Human | Esophagus | ESCC | 1.30e-05 | 1.48e-01 | 0.1124 |
79754 | ASB13 | P21T-E | Human | Esophagus | ESCC | 1.57e-07 | 2.04e-01 | 0.1617 |
79754 | ASB13 | P22T-E | Human | Esophagus | ESCC | 1.50e-04 | 6.81e-02 | 0.1236 |
79754 | ASB13 | P23T-E | Human | Esophagus | ESCC | 3.96e-06 | 1.68e-01 | 0.108 |
79754 | ASB13 | P24T-E | Human | Esophagus | ESCC | 7.00e-14 | 1.59e-01 | 0.1287 |
79754 | ASB13 | P26T-E | Human | Esophagus | ESCC | 1.04e-08 | 1.37e-01 | 0.1276 |
79754 | ASB13 | P27T-E | Human | Esophagus | ESCC | 2.58e-13 | 2.12e-01 | 0.1055 |
79754 | ASB13 | P28T-E | Human | Esophagus | ESCC | 6.95e-06 | 8.32e-02 | 0.1149 |
79754 | ASB13 | P30T-E | Human | Esophagus | ESCC | 5.42e-05 | 2.64e-01 | 0.137 |
79754 | ASB13 | P31T-E | Human | Esophagus | ESCC | 9.33e-12 | 1.60e-01 | 0.1251 |
79754 | ASB13 | P32T-E | Human | Esophagus | ESCC | 8.74e-08 | 2.37e-01 | 0.1666 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ASB13 | SNV | Missense_Mutation | rs754407925 | c.382N>A | p.Gly128Arg | p.G128R | Q8WXK3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BG-A220-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ASB13 | SNV | Missense_Mutation | rs764527518 | c.161N>T | p.Thr54Met | p.T54M | Q8WXK3 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-D1-A1NS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ASB13 | SNV | Missense_Mutation | novel | c.698N>G | p.Glu233Gly | p.E233G | Q8WXK3 | protein_coding | tolerated(0.37) | benign(0.268) | TCGA-DD-AADO-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ASB13 | SNV | Missense_Mutation | novel | c.358N>T | p.Pro120Ser | p.P120S | Q8WXK3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-05-4424-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Targeted Molecular therapy | erlotinib | SD |
ASB13 | SNV | Missense_Mutation | novel | c.382G>T | p.Gly128Trp | p.G128W | Q8WXK3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-49-AAR4-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxol | PD |
ASB13 | SNV | Missense_Mutation | novel | c.740G>C | p.Arg247Thr | p.R247T | Q8WXK3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-56-8622-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ASB13 | SNV | Missense_Mutation | novel | c.247A>G | p.Ile83Val | p.I83V | Q8WXK3 | protein_coding | tolerated(0.17) | benign(0.017) | TCGA-58-A46L-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | CR |
ASB13 | SNV | Missense_Mutation | novel | c.513N>G | p.Asn171Lys | p.N171K | Q8WXK3 | protein_coding | tolerated(0.38) | benign(0.003) | TCGA-68-8250-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ASB13 | SNV | Missense_Mutation | novel | c.805N>T | p.Pro269Ser | p.P269S | Q8WXK3 | protein_coding | tolerated(0.27) | benign(0.001) | TCGA-85-7950-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ASB13 | SNV | Missense_Mutation | novel | c.376N>C | p.Met126Leu | p.M126L | Q8WXK3 | protein_coding | tolerated(0.32) | benign(0.105) | TCGA-CN-4727-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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