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Gene: ARPC1B |
Gene summary for ARPC1B |
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Gene information | Species | Human | Gene symbol | ARPC1B | Gene ID | 10095 |
Gene name | actin related protein 2/3 complex subunit 1B | |
Gene Alias | ARC41 | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | A4D275 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10095 | ARPC1B | GSM4909282 | Human | Breast | IDC | 4.07e-02 | 2.68e-01 | -0.0288 |
10095 | ARPC1B | GSM4909288 | Human | Breast | IDC | 1.87e-03 | 2.42e-02 | 0.0988 |
10095 | ARPC1B | GSM4909290 | Human | Breast | IDC | 3.77e-02 | -2.72e-01 | 0.2096 |
10095 | ARPC1B | GSM4909294 | Human | Breast | IDC | 3.46e-02 | -2.24e-01 | 0.2022 |
10095 | ARPC1B | GSM4909296 | Human | Breast | IDC | 1.47e-04 | 1.78e-01 | 0.1524 |
10095 | ARPC1B | GSM4909297 | Human | Breast | IDC | 8.70e-07 | -1.32e-01 | 0.1517 |
10095 | ARPC1B | GSM4909304 | Human | Breast | IDC | 5.11e-07 | 3.55e-01 | 0.1636 |
10095 | ARPC1B | GSM4909311 | Human | Breast | IDC | 1.12e-19 | -8.78e-02 | 0.1534 |
10095 | ARPC1B | GSM4909312 | Human | Breast | IDC | 1.24e-06 | -1.04e-01 | 0.1552 |
10095 | ARPC1B | GSM4909319 | Human | Breast | IDC | 1.43e-30 | 8.70e-02 | 0.1563 |
10095 | ARPC1B | GSM4909320 | Human | Breast | IDC | 2.22e-03 | -2.12e-01 | 0.1575 |
10095 | ARPC1B | GSM4909321 | Human | Breast | IDC | 3.23e-06 | 2.24e-02 | 0.1559 |
10095 | ARPC1B | brca1 | Human | Breast | Precancer | 3.44e-10 | 5.09e-01 | -0.0338 |
10095 | ARPC1B | brca2 | Human | Breast | Precancer | 7.42e-22 | 5.19e-01 | -0.024 |
10095 | ARPC1B | brca3 | Human | Breast | Precancer | 4.08e-10 | 2.94e-01 | -0.0263 |
10095 | ARPC1B | M2 | Human | Breast | IDC | 9.90e-06 | 3.51e-01 | 0.21 |
10095 | ARPC1B | NCCBC11 | Human | Breast | DCIS | 1.13e-03 | 3.41e-01 | 0.1232 |
10095 | ARPC1B | NCCBC14 | Human | Breast | DCIS | 2.88e-09 | 3.11e-01 | 0.2021 |
10095 | ARPC1B | NCCBC2 | Human | Breast | DCIS | 3.23e-03 | 2.42e-01 | 0.1554 |
10095 | ARPC1B | NCCBC3 | Human | Breast | DCIS | 4.16e-04 | 1.33e-01 | 0.1198 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00432549 | Breast | Precancer | regulation of protein-containing complex assembly | 50/1080 | 428/18723 | 1.63e-06 | 5.97e-05 | 50 |
GO:00313349 | Breast | Precancer | positive regulation of protein-containing complex assembly | 33/1080 | 237/18723 | 2.39e-06 | 8.21e-05 | 33 |
GO:00436273 | Breast | Precancer | response to estrogen | 15/1080 | 75/18723 | 2.06e-05 | 4.83e-04 | 15 |
GO:19029059 | Breast | Precancer | positive regulation of supramolecular fiber organization | 28/1080 | 209/18723 | 2.79e-05 | 6.28e-04 | 28 |
GO:19029039 | Breast | Precancer | regulation of supramolecular fiber organization | 42/1080 | 383/18723 | 4.92e-05 | 1.04e-03 | 42 |
GO:00329709 | Breast | Precancer | regulation of actin filament-based process | 42/1080 | 397/18723 | 1.11e-04 | 2.01e-03 | 42 |
GO:00514959 | Breast | Precancer | positive regulation of cytoskeleton organization | 28/1080 | 226/18723 | 1.13e-04 | 2.04e-03 | 28 |
GO:00070159 | Breast | Precancer | actin filament organization | 44/1080 | 442/18723 | 3.02e-04 | 4.35e-03 | 44 |
GO:00323555 | Breast | Precancer | response to estradiol | 19/1080 | 141/18723 | 4.81e-04 | 6.31e-03 | 19 |
GO:00329569 | Breast | Precancer | regulation of actin cytoskeleton organization | 36/1080 | 358/18723 | 8.56e-04 | 9.88e-03 | 36 |
GO:00322739 | Breast | Precancer | positive regulation of protein polymerization | 18/1080 | 138/18723 | 9.85e-04 | 1.11e-02 | 18 |
GO:01100539 | Breast | Precancer | regulation of actin filament organization | 29/1080 | 278/18723 | 1.50e-03 | 1.55e-02 | 29 |
GO:00343146 | Breast | Precancer | Arp2/3 complex-mediated actin nucleation | 7/1080 | 39/18723 | 6.32e-03 | 4.43e-02 | 7 |
GO:190290514 | Breast | IDC | positive regulation of supramolecular fiber organization | 37/1434 | 209/18723 | 1.33e-06 | 5.75e-05 | 37 |
GO:004325414 | Breast | IDC | regulation of protein-containing complex assembly | 61/1434 | 428/18723 | 1.77e-06 | 7.31e-05 | 61 |
GO:003133414 | Breast | IDC | positive regulation of protein-containing complex assembly | 40/1434 | 237/18723 | 1.77e-06 | 7.31e-05 | 40 |
GO:003297014 | Breast | IDC | regulation of actin filament-based process | 56/1434 | 397/18723 | 6.37e-06 | 1.99e-04 | 56 |
GO:003235512 | Breast | IDC | response to estradiol | 27/1434 | 141/18723 | 7.87e-06 | 2.35e-04 | 27 |
GO:190290314 | Breast | IDC | regulation of supramolecular fiber organization | 54/1434 | 383/18723 | 9.40e-06 | 2.66e-04 | 54 |
GO:004362711 | Breast | IDC | response to estrogen | 17/1434 | 75/18723 | 4.05e-05 | 9.25e-04 | 17 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513218 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0513018 | Breast | Precancer | Pathogenic Escherichia coli infection | 38/684 | 197/8465 | 3.12e-07 | 5.81e-06 | 4.45e-06 | 38 |
hsa0513118 | Breast | Precancer | Shigellosis | 44/684 | 247/8465 | 3.91e-07 | 6.86e-06 | 5.26e-06 | 44 |
hsa0453018 | Breast | Precancer | Tight junction | 31/684 | 169/8465 | 1.13e-05 | 1.26e-04 | 9.64e-05 | 31 |
hsa0510018 | Breast | Precancer | Bacterial invasion of epithelial cells | 16/684 | 77/8465 | 3.55e-04 | 2.80e-03 | 2.15e-03 | 16 |
hsa0513219 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0513019 | Breast | Precancer | Pathogenic Escherichia coli infection | 38/684 | 197/8465 | 3.12e-07 | 5.81e-06 | 4.45e-06 | 38 |
hsa0513119 | Breast | Precancer | Shigellosis | 44/684 | 247/8465 | 3.91e-07 | 6.86e-06 | 5.26e-06 | 44 |
hsa0453019 | Breast | Precancer | Tight junction | 31/684 | 169/8465 | 1.13e-05 | 1.26e-04 | 9.64e-05 | 31 |
hsa0510019 | Breast | Precancer | Bacterial invasion of epithelial cells | 16/684 | 77/8465 | 3.55e-04 | 2.80e-03 | 2.15e-03 | 16 |
hsa0513224 | Breast | IDC | Salmonella infection | 55/867 | 249/8465 | 2.07e-08 | 4.49e-07 | 3.36e-07 | 55 |
hsa0453024 | Breast | IDC | Tight junction | 38/867 | 169/8465 | 2.07e-06 | 3.20e-05 | 2.39e-05 | 38 |
hsa0513024 | Breast | IDC | Pathogenic Escherichia coli infection | 42/867 | 197/8465 | 2.66e-06 | 3.92e-05 | 2.94e-05 | 42 |
hsa0513124 | Breast | IDC | Shigellosis | 47/867 | 247/8465 | 1.78e-05 | 2.00e-04 | 1.49e-04 | 47 |
hsa0510024 | Breast | IDC | Bacterial invasion of epithelial cells | 17/867 | 77/8465 | 1.69e-03 | 1.19e-02 | 8.93e-03 | 17 |
hsa0481014 | Breast | IDC | Regulation of actin cytoskeleton | 36/867 | 229/8465 | 5.79e-03 | 3.13e-02 | 2.34e-02 | 36 |
hsa0513234 | Breast | IDC | Salmonella infection | 55/867 | 249/8465 | 2.07e-08 | 4.49e-07 | 3.36e-07 | 55 |
hsa0453034 | Breast | IDC | Tight junction | 38/867 | 169/8465 | 2.07e-06 | 3.20e-05 | 2.39e-05 | 38 |
hsa0513034 | Breast | IDC | Pathogenic Escherichia coli infection | 42/867 | 197/8465 | 2.66e-06 | 3.92e-05 | 2.94e-05 | 42 |
hsa0513134 | Breast | IDC | Shigellosis | 47/867 | 247/8465 | 1.78e-05 | 2.00e-04 | 1.49e-04 | 47 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARPC1B | SNV | Missense_Mutation | rs767219089 | c.376N>A | p.Glu126Lys | p.E126K | O15143 | protein_coding | tolerated(0.05) | benign(0.02) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARPC1B | SNV | Missense_Mutation | rs779413485 | c.139G>A | p.Glu47Lys | p.E47K | O15143 | protein_coding | tolerated(0.64) | possibly_damaging(0.719) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARPC1B | SNV | Missense_Mutation | novel | c.251N>A | p.Arg84His | p.R84H | O15143 | protein_coding | deleterious(0.04) | benign(0.112) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARPC1B | SNV | Missense_Mutation | novel | c.577N>A | p.Glu193Lys | p.E193K | O15143 | protein_coding | tolerated(0.37) | benign(0.067) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARPC1B | SNV | Missense_Mutation | c.404A>G | p.Lys135Arg | p.K135R | O15143 | protein_coding | tolerated(0.08) | possibly_damaging(0.643) | TCGA-MI-A75G-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ARPC1B | SNV | Missense_Mutation | rs757287136 | c.495N>C | p.Lys165Asn | p.K165N | O15143 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-44-7659-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ARPC1B | SNV | Missense_Mutation | rs776539765 | c.709N>A | p.Val237Ile | p.V237I | O15143 | protein_coding | tolerated(0.23) | benign(0) | TCGA-44-7667-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARPC1B | SNV | Missense_Mutation | novel | c.362N>A | p.Ser121Tyr | p.S121Y | O15143 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-56-8504-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ARPC1B | SNV | Missense_Mutation | novel | c.551N>G | p.Pro184Arg | p.P184R | O15143 | protein_coding | tolerated(0.18) | possibly_damaging(0.82) | TCGA-60-2724-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | SD |
ARPC1B | SNV | Missense_Mutation | novel | c.66N>C | p.Gln22His | p.Q22H | O15143 | protein_coding | deleterious(0.02) | probably_damaging(0.961) | TCGA-77-A5G1-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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