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Gene: ARHGAP45 |
Gene summary for ARHGAP45 |
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Gene information | Species | Human | Gene symbol | ARHGAP45 | Gene ID | 23526 |
Gene name | Rho GTPase activating protein 45 | |
Gene Alias | HA-1 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q92619 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23526 | ARHGAP45 | HCC2 | Human | Liver | HCC | 1.61e-04 | 1.32e+00 | 0.5341 |
23526 | ARHGAP45 | HCC5 | Human | Liver | HCC | 1.37e-02 | 1.24e+00 | 0.4932 |
23526 | ARHGAP45 | S015 | Human | Liver | HCC | 1.08e-05 | 2.41e-01 | 0.2375 |
23526 | ARHGAP45 | S016 | Human | Liver | HCC | 1.19e-05 | 1.77e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARHGAP45 | SNV | Missense_Mutation | c.1810N>A | p.Glu604Lys | p.E604K | Q92619 | protein_coding | tolerated(0.16) | benign(0.288) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ARHGAP45 | SNV | Missense_Mutation | c.1916N>T | p.Ser639Leu | p.S639L | Q92619 | protein_coding | deleterious(0.01) | benign(0.321) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ARHGAP45 | SNV | Missense_Mutation | c.2794N>G | p.Ile932Val | p.I932V | Q92619 | protein_coding | tolerated(0.69) | benign(0.203) | TCGA-CM-6675-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | fluorouracil | PD | |
ARHGAP45 | SNV | Missense_Mutation | c.1475N>G | p.Gln492Arg | p.Q492R | Q92619 | protein_coding | tolerated(0.36) | probably_damaging(0.998) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ARHGAP45 | deletion | Frame_Shift_Del | c.890delG | p.Gly297AlafsTer16 | p.G297Afs*16 | Q92619 | protein_coding | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
ARHGAP45 | deletion | Frame_Shift_Del | c.1420delN | p.Lys474ArgfsTer28 | p.K474Rfs*28 | Q92619 | protein_coding | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
ARHGAP45 | SNV | Missense_Mutation | novel | c.523C>T | p.Arg175Cys | p.R175C | Q92619 | protein_coding | deleterious(0.02) | probably_damaging(0.982) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARHGAP45 | SNV | Missense_Mutation | novel | c.914C>T | p.Ala305Val | p.A305V | Q92619 | protein_coding | deleterious(0.01) | possibly_damaging(0.738) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
ARHGAP45 | SNV | Missense_Mutation | novel | c.1776N>T | p.Lys592Asn | p.K592N | Q92619 | protein_coding | tolerated(0.21) | benign(0.069) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
ARHGAP45 | SNV | Missense_Mutation | rs760322013 | c.166N>A | p.Ala56Thr | p.A56T | Q92619 | protein_coding | tolerated_low_confidence(0.18) | benign(0.009) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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