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Gene: APOOL |
Gene summary for APOOL |
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Gene information | Species | Human | Gene symbol | APOOL | Gene ID | 139322 |
Gene name | apolipoprotein O like | |
Gene Alias | CXorf33 | |
Cytomap | Xq21.1 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q6UXV4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
139322 | APOOL | LZE5T | Human | Esophagus | ESCC | 2.88e-02 | 1.84e-01 | 0.0514 |
139322 | APOOL | LZE24T | Human | Esophagus | ESCC | 3.75e-13 | 3.16e-01 | 0.0596 |
139322 | APOOL | P1T-E | Human | Esophagus | ESCC | 6.84e-07 | 2.57e-01 | 0.0875 |
139322 | APOOL | P2T-E | Human | Esophagus | ESCC | 1.56e-21 | 3.18e-01 | 0.1177 |
139322 | APOOL | P4T-E | Human | Esophagus | ESCC | 3.98e-16 | 3.13e-01 | 0.1323 |
139322 | APOOL | P5T-E | Human | Esophagus | ESCC | 3.17e-13 | 1.71e-01 | 0.1327 |
139322 | APOOL | P8T-E | Human | Esophagus | ESCC | 3.99e-10 | 1.83e-01 | 0.0889 |
139322 | APOOL | P9T-E | Human | Esophagus | ESCC | 5.21e-07 | 1.24e-01 | 0.1131 |
139322 | APOOL | P10T-E | Human | Esophagus | ESCC | 9.06e-11 | 2.06e-01 | 0.116 |
139322 | APOOL | P11T-E | Human | Esophagus | ESCC | 9.72e-07 | 2.42e-01 | 0.1426 |
139322 | APOOL | P12T-E | Human | Esophagus | ESCC | 1.44e-13 | 2.58e-01 | 0.1122 |
139322 | APOOL | P15T-E | Human | Esophagus | ESCC | 6.24e-05 | 1.19e-01 | 0.1149 |
139322 | APOOL | P16T-E | Human | Esophagus | ESCC | 9.69e-07 | 9.93e-02 | 0.1153 |
139322 | APOOL | P20T-E | Human | Esophagus | ESCC | 4.69e-12 | 2.12e-01 | 0.1124 |
139322 | APOOL | P21T-E | Human | Esophagus | ESCC | 1.35e-10 | 1.59e-01 | 0.1617 |
139322 | APOOL | P22T-E | Human | Esophagus | ESCC | 1.37e-11 | 2.37e-01 | 0.1236 |
139322 | APOOL | P23T-E | Human | Esophagus | ESCC | 1.01e-11 | 1.47e-01 | 0.108 |
139322 | APOOL | P24T-E | Human | Esophagus | ESCC | 3.00e-09 | 1.60e-01 | 0.1287 |
139322 | APOOL | P26T-E | Human | Esophagus | ESCC | 8.97e-20 | 3.49e-01 | 0.1276 |
139322 | APOOL | P27T-E | Human | Esophagus | ESCC | 3.91e-13 | 9.22e-02 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000700619 | Esophagus | ESCC | mitochondrial membrane organization | 93/8552 | 116/18723 | 2.16e-14 | 1.11e-12 | 93 |
GO:000700713 | Esophagus | ESCC | inner mitochondrial membrane organization | 31/8552 | 38/18723 | 5.93e-06 | 6.10e-05 | 31 |
GO:00424072 | Esophagus | ESCC | cristae formation | 13/8552 | 16/18723 | 4.05e-03 | 1.62e-02 | 13 |
GO:000700612 | Liver | HCC | mitochondrial membrane organization | 80/7958 | 116/18723 | 7.09e-09 | 1.81e-07 | 80 |
GO:000700711 | Liver | HCC | inner mitochondrial membrane organization | 28/7958 | 38/18723 | 9.60e-05 | 8.34e-04 | 28 |
GO:0042407 | Liver | HCC | cristae formation | 12/7958 | 16/18723 | 8.74e-03 | 3.40e-02 | 12 |
GO:000700610 | Oral cavity | OSCC | mitochondrial membrane organization | 85/7305 | 116/18723 | 6.29e-14 | 3.40e-12 | 85 |
GO:00070075 | Oral cavity | OSCC | inner mitochondrial membrane organization | 27/7305 | 38/18723 | 6.23e-05 | 5.08e-04 | 27 |
GO:00424071 | Oral cavity | OSCC | cristae formation | 12/7305 | 16/18723 | 3.83e-03 | 1.57e-02 | 12 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
APOOL | insertion | Frame_Shift_Ins | novel | c.589_590insA | p.Thr199AsnfsTer2 | p.T199Nfs*2 | Q6UXV4 | protein_coding | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | ||
APOOL | SNV | Missense_Mutation | novel | c.86N>G | p.Glu29Gly | p.E29G | Q6UXV4 | protein_coding | deleterious(0) | benign(0.355) | TCGA-RC-A6M4-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
APOOL | SNV | Missense_Mutation | c.605N>T | p.Gly202Val | p.G202V | Q6UXV4 | protein_coding | tolerated(0.09) | possibly_damaging(0.695) | TCGA-44-A479-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
APOOL | SNV | Missense_Mutation | c.719N>T | p.Gly240Val | p.G240V | Q6UXV4 | protein_coding | deleterious(0.01) | probably_damaging(0.96) | TCGA-55-7995-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR | |
APOOL | SNV | Missense_Mutation | novel | c.739G>T | p.Asp247Tyr | p.D247Y | Q6UXV4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-99-7458-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Targeted Molecular therapy | tarceva | SD |
APOOL | SNV | Missense_Mutation | novel | c.205C>A | p.Arg69Ser | p.R69S | Q6UXV4 | protein_coding | deleterious(0) | possibly_damaging(0.891) | TCGA-18-3411-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
APOOL | SNV | Missense_Mutation | c.345N>T | p.Met115Ile | p.M115I | Q6UXV4 | protein_coding | tolerated(0.41) | benign(0) | TCGA-43-3394-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | gemzar | PD | |
APOOL | SNV | Missense_Mutation | novel | c.167N>T | p.Glu56Val | p.E56V | Q6UXV4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-63-A5MB-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
APOOL | SNV | Missense_Mutation | c.13N>G | p.Arg5Gly | p.R5G | Q6UXV4 | protein_coding | deleterious(0.01) | benign(0.037) | TCGA-CG-4465-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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