![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: APOL4 |
Gene summary for APOL4 |
![]() |
Gene information | Species | Human | Gene symbol | APOL4 | Gene ID | 80832 |
Gene name | apolipoprotein L4 | |
Gene Alias | APOL-IV | |
Cytomap | 22q12.3 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q9BPW4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80832 | APOL4 | HCC1 | Human | Liver | HCC | 1.89e-02 | 2.20e+00 | 0.5336 |
80832 | APOL4 | HCC2 | Human | Liver | HCC | 1.21e-05 | 1.47e+00 | 0.5341 |
80832 | APOL4 | S014 | Human | Liver | HCC | 2.64e-07 | 2.99e-01 | 0.2254 |
80832 | APOL4 | S015 | Human | Liver | HCC | 9.93e-07 | 2.32e-01 | 0.2375 |
80832 | APOL4 | S016 | Human | Liver | HCC | 3.39e-02 | 1.29e-01 | 0.2243 |
80832 | APOL4 | S029 | Human | Liver | HCC | 8.89e-06 | 2.57e-01 | 0.2581 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00421571 | Liver | HCC | lipoprotein metabolic process | 86/7958 | 135/18723 | 5.21e-07 | 8.38e-06 | 86 |
GO:001087621 | Liver | HCC | lipid localization | 228/7958 | 448/18723 | 1.80e-04 | 1.41e-03 | 228 |
GO:000686921 | Liver | HCC | lipid transport | 198/7958 | 398/18723 | 1.92e-03 | 9.78e-03 | 198 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
APOL4 | SNV | Missense_Mutation | novel | c.557N>T | p.Gly186Val | p.G186V | Q9BPW4 | protein_coding | deleterious(0.01) | benign(0.185) | TCGA-63-7020-01 | Lung | lung squamous cell carcinoma | Male | Unknown | I/II | Unknown | Unknown | SD |
APOL4 | SNV | Missense_Mutation | novel | c.186G>T | p.Trp62Cys | p.W62C | Q9BPW4 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-85-8350-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
APOL4 | SNV | Missense_Mutation | novel | c.151N>T | p.His51Tyr | p.H51Y | Q9BPW4 | protein_coding | tolerated(0.13) | benign(0.144) | TCGA-CV-A45T-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
APOL4 | SNV | Missense_Mutation | novel | c.691T>C | p.Ser231Pro | p.S231P | Q9BPW4 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-IQ-A6SH-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
APOL4 | SNV | Missense_Mutation | rs773097290 | c.454A>G | p.Ile152Val | p.I152V | Q9BPW4 | protein_coding | tolerated(0.42) | benign(0.003) | TCGA-ZG-A9ND-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
APOL4 | SNV | Missense_Mutation | c.812N>C | p.Val271Ala | p.V271A | Q9BPW4 | protein_coding | tolerated(0.76) | benign(0.003) | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
APOL4 | SNV | Missense_Mutation | novel | c.218G>T | p.Arg73Met | p.R73M | Q9BPW4 | protein_coding | deleterious(0) | possibly_damaging(0.579) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |