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Gene: AP5B1 |
Gene summary for AP5B1 |
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Gene information | Species | Human | Gene symbol | AP5B1 | Gene ID | 91056 |
Gene name | adaptor related protein complex 5 subunit beta 1 | |
Gene Alias | AP-5 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q2VPB7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91056 | AP5B1 | HCC1_Meng | Human | Liver | HCC | 1.61e-12 | 8.74e-03 | 0.0246 |
91056 | AP5B1 | HCC2_Meng | Human | Liver | HCC | 7.87e-04 | 3.55e-02 | 0.0107 |
91056 | AP5B1 | HCC1 | Human | Liver | HCC | 1.90e-12 | 1.03e+00 | 0.5336 |
91056 | AP5B1 | HCC2 | Human | Liver | HCC | 1.40e-20 | 1.58e+00 | 0.5341 |
91056 | AP5B1 | HCC5 | Human | Liver | HCC | 1.26e-19 | 1.54e+00 | 0.4932 |
91056 | AP5B1 | S027 | Human | Liver | HCC | 3.70e-02 | 2.12e-01 | 0.2446 |
91056 | AP5B1 | S028 | Human | Liver | HCC | 6.96e-07 | 2.52e-01 | 0.2503 |
91056 | AP5B1 | S029 | Human | Liver | HCC | 9.47e-05 | 2.72e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001619721 | Liver | HCC | endosomal transport | 154/7958 | 230/18723 | 4.74e-14 | 2.95e-12 | 154 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AP5B1 | SNV | Missense_Mutation | novel | c.566N>C | p.Leu189Pro | p.L189P | Q2VPB7 | protein_coding | deleterious(0.02) | probably_damaging(0.991) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AP5B1 | SNV | Missense_Mutation | novel | c.1859N>T | p.Ala620Val | p.A620V | Q2VPB7 | protein_coding | tolerated(0.08) | benign(0.015) | TCGA-AX-A2HA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AP5B1 | SNV | Missense_Mutation | rs766354109 | c.986N>T | p.Ala329Val | p.A329V | Q2VPB7 | protein_coding | tolerated(0.33) | possibly_damaging(0.727) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
AP5B1 | SNV | Missense_Mutation | novel | c.8N>A | p.Pro3His | p.P3H | Q2VPB7 | protein_coding | deleterious(0.02) | possibly_damaging(0.88) | TCGA-AX-A2HG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AP5B1 | SNV | Missense_Mutation | novel | c.1496T>G | p.Met499Arg | p.M499R | Q2VPB7 | protein_coding | tolerated(0.5) | benign(0.048) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
AP5B1 | SNV | Missense_Mutation | rs745506104 | c.2156N>A | p.Arg719His | p.R719H | Q2VPB7 | protein_coding | tolerated(0.14) | benign(0.01) | TCGA-E6-A1M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
AP5B1 | SNV | Missense_Mutation | novel | c.484N>T | p.Pro162Ser | p.P162S | Q2VPB7 | protein_coding | tolerated(0.06) | probably_damaging(0.999) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AP5B1 | SNV | Missense_Mutation | novel | c.1387A>G | p.Thr463Ala | p.T463A | Q2VPB7 | protein_coding | tolerated(0.2) | benign(0.023) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AP5B1 | SNV | Missense_Mutation | rs746935679 | c.1085C>T | p.Pro362Leu | p.P362L | Q2VPB7 | protein_coding | tolerated(0.39) | benign(0) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AP5B1 | SNV | Missense_Mutation | c.1659G>T | p.Gln553His | p.Q553H | Q2VPB7 | protein_coding | deleterious(0.03) | benign(0.01) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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