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Gene: AP1M1 |
Gene summary for AP1M1 |
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Gene information | Species | Human | Gene symbol | AP1M1 | Gene ID | 8907 |
Gene name | adaptor related protein complex 1 subunit mu 1 | |
Gene Alias | AP47 | |
Cytomap | 19p13.11 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q59EK3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8907 | AP1M1 | LZE4T | Human | Esophagus | ESCC | 9.72e-06 | 2.33e-01 | 0.0811 |
8907 | AP1M1 | LZE7T | Human | Esophagus | ESCC | 5.26e-04 | 2.44e-01 | 0.0667 |
8907 | AP1M1 | LZE22T | Human | Esophagus | ESCC | 2.74e-04 | 3.84e-01 | 0.068 |
8907 | AP1M1 | LZE24T | Human | Esophagus | ESCC | 2.01e-08 | 1.62e-01 | 0.0596 |
8907 | AP1M1 | LZE21T | Human | Esophagus | ESCC | 4.13e-02 | 2.20e-01 | 0.0655 |
8907 | AP1M1 | P1T-E | Human | Esophagus | ESCC | 6.05e-06 | 2.91e-01 | 0.0875 |
8907 | AP1M1 | P2T-E | Human | Esophagus | ESCC | 1.87e-23 | 2.86e-01 | 0.1177 |
8907 | AP1M1 | P4T-E | Human | Esophagus | ESCC | 1.74e-12 | 3.12e-01 | 0.1323 |
8907 | AP1M1 | P5T-E | Human | Esophagus | ESCC | 2.36e-23 | 4.07e-01 | 0.1327 |
8907 | AP1M1 | P8T-E | Human | Esophagus | ESCC | 7.37e-26 | 3.81e-01 | 0.0889 |
8907 | AP1M1 | P9T-E | Human | Esophagus | ESCC | 8.61e-11 | 2.81e-01 | 0.1131 |
8907 | AP1M1 | P10T-E | Human | Esophagus | ESCC | 5.40e-33 | 5.21e-01 | 0.116 |
8907 | AP1M1 | P11T-E | Human | Esophagus | ESCC | 1.18e-18 | 5.84e-01 | 0.1426 |
8907 | AP1M1 | P12T-E | Human | Esophagus | ESCC | 4.97e-19 | 3.12e-01 | 0.1122 |
8907 | AP1M1 | P15T-E | Human | Esophagus | ESCC | 2.83e-11 | 2.53e-01 | 0.1149 |
8907 | AP1M1 | P16T-E | Human | Esophagus | ESCC | 1.81e-10 | 2.20e-01 | 0.1153 |
8907 | AP1M1 | P17T-E | Human | Esophagus | ESCC | 4.70e-12 | 5.40e-01 | 0.1278 |
8907 | AP1M1 | P19T-E | Human | Esophagus | ESCC | 1.86e-17 | 7.78e-01 | 0.1662 |
8907 | AP1M1 | P20T-E | Human | Esophagus | ESCC | 2.52e-17 | 3.23e-01 | 0.1124 |
8907 | AP1M1 | P21T-E | Human | Esophagus | ESCC | 6.21e-28 | 5.79e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001605014 | Esophagus | ESCC | vesicle organization | 211/8552 | 300/18723 | 2.85e-18 | 2.87e-16 | 211 |
GO:00330593 | Esophagus | ESCC | cellular pigmentation | 40/8552 | 53/18723 | 9.67e-06 | 9.21e-05 | 40 |
GO:00487531 | Esophagus | ESCC | pigment granule organization | 23/8552 | 29/18723 | 2.25e-04 | 1.40e-03 | 23 |
GO:00324381 | Esophagus | ESCC | melanosome organization | 22/8552 | 28/18723 | 3.95e-04 | 2.26e-03 | 22 |
GO:00434731 | Esophagus | ESCC | pigmentation | 59/8552 | 98/18723 | 2.64e-03 | 1.12e-02 | 59 |
GO:0035646 | Esophagus | ESCC | endosome to melanosome transport | 9/8552 | 10/18723 | 5.09e-03 | 1.92e-02 | 9 |
GO:0043485 | Esophagus | ESCC | endosome to pigment granule transport | 9/8552 | 10/18723 | 5.09e-03 | 1.92e-02 | 9 |
GO:0048757 | Esophagus | ESCC | pigment granule maturation | 9/8552 | 10/18723 | 5.09e-03 | 1.92e-02 | 9 |
GO:0043476 | Esophagus | ESCC | pigment accumulation | 10/8552 | 12/18723 | 8.94e-03 | 3.12e-02 | 10 |
GO:0043482 | Esophagus | ESCC | cellular pigment accumulation | 10/8552 | 12/18723 | 8.94e-03 | 3.12e-02 | 10 |
GO:001605021 | Liver | HCC | vesicle organization | 194/7958 | 300/18723 | 5.58e-15 | 3.97e-13 | 194 |
GO:00160508 | Oral cavity | OSCC | vesicle organization | 189/7305 | 300/18723 | 2.40e-17 | 2.14e-15 | 189 |
GO:0033059 | Oral cavity | OSCC | cellular pigmentation | 33/7305 | 53/18723 | 5.11e-04 | 2.98e-03 | 33 |
GO:0048753 | Oral cavity | OSCC | pigment granule organization | 20/7305 | 29/18723 | 1.05e-03 | 5.39e-03 | 20 |
GO:0032438 | Oral cavity | OSCC | melanosome organization | 19/7305 | 28/18723 | 1.88e-03 | 8.84e-03 | 19 |
GO:001605013 | Oral cavity | LP | vesicle organization | 128/4623 | 300/18723 | 4.96e-12 | 3.98e-10 | 128 |
GO:00330591 | Oral cavity | LP | cellular pigmentation | 22/4623 | 53/18723 | 5.20e-03 | 3.19e-02 | 22 |
GO:001605017 | Thyroid | PTC | vesicle organization | 163/5968 | 300/18723 | 4.74e-16 | 3.69e-14 | 163 |
GO:001605023 | Thyroid | ATC | vesicle organization | 166/6293 | 300/18723 | 6.14e-15 | 3.92e-13 | 166 |
GO:00330595 | Thyroid | ATC | cellular pigmentation | 26/6293 | 53/18723 | 1.42e-02 | 4.91e-02 | 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414222 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa05170210 | Esophagus | ESCC | Human immunodeficiency virus 1 infection | 147/4205 | 212/8465 | 3.37e-09 | 3.53e-08 | 1.81e-08 | 147 |
hsa0414232 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa0517038 | Esophagus | ESCC | Human immunodeficiency virus 1 infection | 147/4205 | 212/8465 | 3.37e-09 | 3.53e-08 | 1.81e-08 | 147 |
hsa041422 | Liver | HCC | Lysosome | 100/4020 | 132/8465 | 2.32e-11 | 4.31e-10 | 2.40e-10 | 100 |
hsa051709 | Liver | HCC | Human immunodeficiency virus 1 infection | 125/4020 | 212/8465 | 4.51e-04 | 1.94e-03 | 1.08e-03 | 125 |
hsa041423 | Liver | HCC | Lysosome | 100/4020 | 132/8465 | 2.32e-11 | 4.31e-10 | 2.40e-10 | 100 |
hsa0517012 | Liver | HCC | Human immunodeficiency virus 1 infection | 125/4020 | 212/8465 | 4.51e-04 | 1.94e-03 | 1.08e-03 | 125 |
hsa0517027 | Oral cavity | OSCC | Human immunodeficiency virus 1 infection | 133/3704 | 212/8465 | 1.42e-08 | 1.40e-07 | 7.12e-08 | 133 |
hsa041425 | Oral cavity | OSCC | Lysosome | 87/3704 | 132/8465 | 1.97e-07 | 1.35e-06 | 6.86e-07 | 87 |
hsa05170111 | Oral cavity | OSCC | Human immunodeficiency virus 1 infection | 133/3704 | 212/8465 | 1.42e-08 | 1.40e-07 | 7.12e-08 | 133 |
hsa0414212 | Oral cavity | OSCC | Lysosome | 87/3704 | 132/8465 | 1.97e-07 | 1.35e-06 | 6.86e-07 | 87 |
hsa0414221 | Oral cavity | LP | Lysosome | 67/2418 | 132/8465 | 5.13e-08 | 7.77e-07 | 5.01e-07 | 67 |
hsa0517028 | Oral cavity | LP | Human immunodeficiency virus 1 infection | 92/2418 | 212/8465 | 2.18e-06 | 2.20e-05 | 1.42e-05 | 92 |
hsa0414231 | Oral cavity | LP | Lysosome | 67/2418 | 132/8465 | 5.13e-08 | 7.77e-07 | 5.01e-07 | 67 |
hsa0517037 | Oral cavity | LP | Human immunodeficiency virus 1 infection | 92/2418 | 212/8465 | 2.18e-06 | 2.20e-05 | 1.42e-05 | 92 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AP1M1 | SNV | Missense_Mutation | novel | c.53G>A | p.Cys18Tyr | p.C18Y | Q9BXS5 | protein_coding | tolerated(0.36) | benign(0.285) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AP1M1 | SNV | Missense_Mutation | novel | c.445C>T | p.Pro149Ser | p.P149S | Q9BXS5 | protein_coding | deleterious(0.03) | possibly_damaging(0.544) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AP1M1 | SNV | Missense_Mutation | novel | c.344A>T | p.Asp115Val | p.D115V | Q9BXS5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A1DP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | PD |
AP1M1 | SNV | Missense_Mutation | novel | c.704N>T | p.Thr235Met | p.T235M | Q9BXS5 | protein_coding | deleterious(0.05) | probably_damaging(0.938) | TCGA-AX-A0IZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AP1M1 | SNV | Missense_Mutation | rs766864704 | c.763N>T | p.Arg255Trp | p.R255W | Q9BXS5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
AP1M1 | SNV | Missense_Mutation | novel | c.314N>G | p.Asp105Gly | p.D105G | Q9BXS5 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
AP1M1 | SNV | Missense_Mutation | c.382N>G | p.Ser128Gly | p.S128G | Q9BXS5 | protein_coding | tolerated(0.1) | benign(0.042) | TCGA-B5-A0JZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
AP1M1 | SNV | Missense_Mutation | novel | c.905G>A | p.Arg302His | p.R302H | Q9BXS5 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AP1M1 | SNV | Missense_Mutation | novel | c.443N>A | p.Arg148Gln | p.R148Q | Q9BXS5 | protein_coding | tolerated(0.11) | possibly_damaging(0.627) | TCGA-BG-A221-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AP1M1 | SNV | Missense_Mutation | c.439N>A | p.Pro147Thr | p.P147T | Q9BXS5 | protein_coding | tolerated(0.07) | benign(0.015) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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