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Gene: ANTXR1 |
Gene summary for ANTXR1 |
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Gene information | Species | Human | Gene symbol | ANTXR1 | Gene ID | 84168 |
Gene name | ANTXR cell adhesion molecule 1 | |
Gene Alias | ATR | |
Cytomap | 2p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q96EC6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84168 | ANTXR1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.25e-02 | 1.40e-01 | 0.0155 |
84168 | ANTXR1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.57e-05 | 2.18e-01 | -0.1808 |
84168 | ANTXR1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.43e-12 | 6.44e-01 | -0.0811 |
84168 | ANTXR1 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.00e-03 | 2.56e-01 | -0.1088 |
84168 | ANTXR1 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.61e-07 | 2.04e-01 | -0.1954 |
84168 | ANTXR1 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.08e-11 | 2.77e-01 | -0.1464 |
84168 | ANTXR1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.36e-04 | 7.04e-02 | -0.1001 |
84168 | ANTXR1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.12e-07 | 2.36e-01 | -0.059 |
84168 | ANTXR1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 2.25e-05 | 5.13e-01 | 0.0451 |
84168 | ANTXR1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.06e-06 | 1.63e-01 | 0.0674 |
84168 | ANTXR1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.87e-46 | 7.80e-01 | 0.294 |
84168 | ANTXR1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.73e-03 | 1.88e-01 | 0.281 |
84168 | ANTXR1 | LZE8T | Human | Esophagus | ESCC | 1.05e-03 | -3.58e-02 | 0.067 |
84168 | ANTXR1 | LZE24T | Human | Esophagus | ESCC | 4.33e-07 | 1.22e-01 | 0.0596 |
84168 | ANTXR1 | LZE21T | Human | Esophagus | ESCC | 1.15e-02 | 2.51e-02 | 0.0655 |
84168 | ANTXR1 | P1T-E | Human | Esophagus | ESCC | 8.34e-03 | 4.64e-02 | 0.0875 |
84168 | ANTXR1 | P2T-E | Human | Esophagus | ESCC | 2.73e-19 | 4.04e-01 | 0.1177 |
84168 | ANTXR1 | P4T-E | Human | Esophagus | ESCC | 3.05e-15 | 7.13e-01 | 0.1323 |
84168 | ANTXR1 | P8T-E | Human | Esophagus | ESCC | 4.64e-10 | 3.32e-01 | 0.0889 |
84168 | ANTXR1 | P9T-E | Human | Esophagus | ESCC | 6.74e-06 | 5.31e-01 | 0.1131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0045862 | Colorectum | AD | positive regulation of proteolysis | 129/3918 | 372/18723 | 4.04e-10 | 3.46e-08 | 129 |
GO:0031589 | Colorectum | AD | cell-substrate adhesion | 116/3918 | 363/18723 | 4.68e-07 | 1.76e-05 | 116 |
GO:0052547 | Colorectum | AD | regulation of peptidase activity | 137/3918 | 461/18723 | 4.12e-06 | 1.12e-04 | 137 |
GO:0010952 | Colorectum | AD | positive regulation of peptidase activity | 68/3918 | 197/18723 | 6.30e-06 | 1.59e-04 | 68 |
GO:0031532 | Colorectum | AD | actin cytoskeleton reorganization | 41/3918 | 107/18723 | 2.81e-05 | 5.28e-04 | 41 |
GO:0034446 | Colorectum | AD | substrate adhesion-dependent cell spreading | 40/3918 | 108/18723 | 8.52e-05 | 1.32e-03 | 40 |
GO:00458621 | Colorectum | SER | positive regulation of proteolysis | 106/2897 | 372/18723 | 8.40e-11 | 1.20e-08 | 106 |
GO:00525471 | Colorectum | SER | regulation of peptidase activity | 114/2897 | 461/18723 | 1.18e-07 | 7.17e-06 | 114 |
GO:00109521 | Colorectum | SER | positive regulation of peptidase activity | 55/2897 | 197/18723 | 5.44e-06 | 2.00e-04 | 55 |
GO:00315891 | Colorectum | SER | cell-substrate adhesion | 86/2897 | 363/18723 | 2.36e-05 | 6.64e-04 | 86 |
GO:00344461 | Colorectum | SER | substrate adhesion-dependent cell spreading | 32/2897 | 108/18723 | 1.42e-04 | 2.82e-03 | 32 |
GO:00315321 | Colorectum | SER | actin cytoskeleton reorganization | 30/2897 | 107/18723 | 6.38e-04 | 8.64e-03 | 30 |
GO:00458622 | Colorectum | MSS | positive regulation of proteolysis | 119/3467 | 372/18723 | 2.14e-10 | 2.09e-08 | 119 |
GO:00525472 | Colorectum | MSS | regulation of peptidase activity | 130/3467 | 461/18723 | 1.81e-07 | 8.13e-06 | 130 |
GO:00315322 | Colorectum | MSS | actin cytoskeleton reorganization | 41/3467 | 107/18723 | 1.21e-06 | 4.06e-05 | 41 |
GO:00315892 | Colorectum | MSS | cell-substrate adhesion | 104/3467 | 363/18723 | 1.35e-06 | 4.51e-05 | 104 |
GO:00109522 | Colorectum | MSS | positive regulation of peptidase activity | 63/3467 | 197/18723 | 3.65e-06 | 1.06e-04 | 63 |
GO:00344462 | Colorectum | MSS | substrate adhesion-dependent cell spreading | 39/3467 | 108/18723 | 1.15e-05 | 2.71e-04 | 39 |
GO:1905050 | Colorectum | MSS | positive regulation of metallopeptidase activity | 6/3467 | 11/18723 | 7.89e-03 | 4.84e-02 | 6 |
GO:0045862111 | Esophagus | ESCC | positive regulation of proteolysis | 256/8552 | 372/18723 | 7.88e-20 | 9.43e-18 | 256 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0462122 | Esophagus | ESCC | NOD-like receptor signaling pathway | 116/4205 | 186/8465 | 2.90e-04 | 1.03e-03 | 5.30e-04 | 116 |
hsa0462132 | Esophagus | ESCC | NOD-like receptor signaling pathway | 116/4205 | 186/8465 | 2.90e-04 | 1.03e-03 | 5.30e-04 | 116 |
hsa046218 | Oral cavity | OSCC | NOD-like receptor signaling pathway | 108/3704 | 186/8465 | 5.13e-05 | 2.07e-04 | 1.05e-04 | 108 |
hsa0462113 | Oral cavity | OSCC | NOD-like receptor signaling pathway | 108/3704 | 186/8465 | 5.13e-05 | 2.07e-04 | 1.05e-04 | 108 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANTXR1 | SNV | Missense_Mutation | rs778487700 | c.430N>A | p.Val144Ile | p.V144I | Q9H6X2 | protein_coding | tolerated(0.77) | probably_damaging(0.998) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
ANTXR1 | SNV | Missense_Mutation | c.359N>C | p.Met120Thr | p.M120T | Q9H6X2 | protein_coding | tolerated(0.05) | probably_damaging(0.999) | TCGA-DY-A1DC-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Chemotherapy | capecitabine | PR | |
ANTXR1 | SNV | Missense_Mutation | novel | c.142N>G | p.Ile48Val | p.I48V | Q9H6X2 | protein_coding | tolerated(1) | benign(0.001) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ANTXR1 | SNV | Missense_Mutation | novel | c.1363N>A | p.Asp455Asn | p.D455N | Q9H6X2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
ANTXR1 | SNV | Missense_Mutation | novel | c.356N>G | p.Tyr119Cys | p.Y119C | Q9H6X2 | protein_coding | deleterious(0.02) | possibly_damaging(0.896) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
ANTXR1 | SNV | Missense_Mutation | novel | c.628N>T | p.Gly210Cys | p.G210C | Q9H6X2 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANTXR1 | SNV | Missense_Mutation | novel | c.920N>T | p.Ser307Phe | p.S307F | Q9H6X2 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
ANTXR1 | SNV | Missense_Mutation | c.938N>T | p.Thr313Ile | p.T313I | Q9H6X2 | protein_coding | tolerated(0.06) | probably_damaging(0.933) | TCGA-AX-A1C5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | SD | |
ANTXR1 | SNV | Missense_Mutation | c.1178N>T | p.Arg393Ile | p.R393I | Q9H6X2 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
ANTXR1 | SNV | Missense_Mutation | c.766N>A | p.Leu256Ile | p.L256I | Q9H6X2 | protein_coding | tolerated(0.16) | probably_damaging(0.915) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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