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Gene: ANPEP |
Gene summary for ANPEP |
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Gene information | Species | Human | Gene symbol | ANPEP | Gene ID | 290 |
Gene name | alanyl aminopeptidase, membrane | |
Gene Alias | APN | |
Cytomap | 15q26.1 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | A0A024RC61 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
290 | ANPEP | GSM4909299 | Human | Breast | IDC | 5.88e-04 | 2.28e-01 | 0.035 |
290 | ANPEP | GSM4909308 | Human | Breast | IDC | 2.82e-02 | -1.20e-01 | 0.158 |
290 | ANPEP | brca10 | Human | Breast | Precancer | 4.07e-02 | -1.20e-01 | -0.0029 |
290 | ANPEP | DCIS2 | Human | Breast | DCIS | 5.45e-57 | 5.58e-01 | 0.0085 |
290 | ANPEP | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.14e-11 | -3.49e-01 | 0.0155 |
290 | ANPEP | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.05e-17 | 2.39e+00 | -0.1808 |
290 | ANPEP | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.07e-38 | 3.02e+00 | -0.0811 |
290 | ANPEP | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.96e-03 | 2.01e+00 | -0.2196 |
290 | ANPEP | HTA11_83_2000001011 | Human | Colorectum | SER | 2.44e-14 | 2.52e+00 | -0.1526 |
290 | ANPEP | HTA11_866_3004761011 | Human | Colorectum | AD | 2.09e-09 | -3.48e-01 | 0.096 |
290 | ANPEP | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.68e-10 | -3.46e-01 | 0.0674 |
290 | ANPEP | HTA11_6818_2000001021 | Human | Colorectum | AD | 7.67e-03 | -3.40e-01 | 0.0588 |
290 | ANPEP | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.58e-13 | -3.54e-01 | 0.294 |
290 | ANPEP | HTA11_99999965104_69814 | Human | Colorectum | MSS | 9.31e-03 | -3.29e-01 | 0.281 |
290 | ANPEP | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.73e-11 | -3.50e-01 | 0.3859 |
290 | ANPEP | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.72e-06 | -3.14e-01 | 0.3005 |
290 | ANPEP | F007 | Human | Colorectum | FAP | 7.01e-05 | -3.29e-01 | 0.1176 |
290 | ANPEP | A002-C-010 | Human | Colorectum | FAP | 7.06e-09 | -3.46e-01 | 0.242 |
290 | ANPEP | A001-C-207 | Human | Colorectum | FAP | 5.27e-05 | -2.85e-01 | 0.1278 |
290 | ANPEP | A015-C-203 | Human | Colorectum | FAP | 1.61e-05 | -2.38e-01 | -0.1294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00160329 | Breast | Precancer | viral process | 58/1080 | 415/18723 | 3.42e-10 | 3.16e-08 | 58 |
GO:00190589 | Breast | Precancer | viral life cycle | 47/1080 | 317/18723 | 2.42e-09 | 1.99e-07 | 47 |
GO:00444039 | Breast | Precancer | biological process involved in symbiotic interaction | 42/1080 | 290/18723 | 3.40e-08 | 2.11e-06 | 42 |
GO:00521269 | Breast | Precancer | movement in host environment | 29/1080 | 175/18723 | 2.59e-07 | 1.28e-05 | 29 |
GO:00517019 | Breast | Precancer | biological process involved in interaction with host | 31/1080 | 203/18723 | 6.52e-07 | 2.71e-05 | 31 |
GO:00444099 | Breast | Precancer | entry into host | 25/1080 | 151/18723 | 1.74e-06 | 6.19e-05 | 25 |
GO:00467189 | Breast | Precancer | viral entry into host cell | 24/1080 | 144/18723 | 2.46e-06 | 8.35e-05 | 24 |
GO:001603214 | Breast | IDC | viral process | 75/1434 | 415/18723 | 1.98e-12 | 4.02e-10 | 75 |
GO:001905814 | Breast | IDC | viral life cycle | 61/1434 | 317/18723 | 1.61e-11 | 2.77e-09 | 61 |
GO:004440314 | Breast | IDC | biological process involved in symbiotic interaction | 52/1434 | 290/18723 | 6.55e-09 | 5.03e-07 | 52 |
GO:005212614 | Breast | IDC | movement in host environment | 32/1434 | 175/18723 | 3.33e-06 | 1.22e-04 | 32 |
GO:005170114 | Breast | IDC | biological process involved in interaction with host | 35/1434 | 203/18723 | 4.72e-06 | 1.63e-04 | 35 |
GO:004440914 | Breast | IDC | entry into host | 28/1434 | 151/18723 | 1.02e-05 | 2.82e-04 | 28 |
GO:004671814 | Breast | IDC | viral entry into host cell | 27/1434 | 144/18723 | 1.18e-05 | 3.14e-04 | 27 |
GO:001603224 | Breast | DCIS | viral process | 73/1390 | 415/18723 | 3.40e-12 | 6.88e-10 | 73 |
GO:001905824 | Breast | DCIS | viral life cycle | 59/1390 | 317/18723 | 4.05e-11 | 5.74e-09 | 59 |
GO:004440323 | Breast | DCIS | biological process involved in symbiotic interaction | 49/1390 | 290/18723 | 4.70e-08 | 2.89e-06 | 49 |
GO:005212624 | Breast | DCIS | movement in host environment | 31/1390 | 175/18723 | 4.93e-06 | 1.45e-04 | 31 |
GO:005170124 | Breast | DCIS | biological process involved in interaction with host | 34/1390 | 203/18723 | 6.30e-06 | 1.78e-04 | 34 |
GO:004440924 | Breast | DCIS | entry into host | 27/1390 | 151/18723 | 1.65e-05 | 4.00e-04 | 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa004809 | Liver | Cirrhotic | Glutathione metabolism | 30/2530 | 57/8465 | 2.63e-04 | 1.72e-03 | 1.06e-03 | 30 |
hsa0048012 | Liver | Cirrhotic | Glutathione metabolism | 30/2530 | 57/8465 | 2.63e-04 | 1.72e-03 | 1.06e-03 | 30 |
hsa0048022 | Liver | HCC | Glutathione metabolism | 42/4020 | 57/8465 | 5.00e-05 | 2.62e-04 | 1.46e-04 | 42 |
hsa0048032 | Liver | HCC | Glutathione metabolism | 42/4020 | 57/8465 | 5.00e-05 | 2.62e-04 | 1.46e-04 | 42 |
hsa0048014 | Prostate | Tumor | Glutathione metabolism | 20/1791 | 57/8465 | 1.05e-02 | 3.33e-02 | 2.07e-02 | 20 |
hsa0048015 | Prostate | Tumor | Glutathione metabolism | 20/1791 | 57/8465 | 1.05e-02 | 3.33e-02 | 2.07e-02 | 20 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANPEP | SNV | Missense_Mutation | rs866441038 | c.1972N>T | p.Arg658Trp | p.R658W | P15144 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ANPEP | SNV | Missense_Mutation | c.2779N>A | p.Glu927Lys | p.E927K | P15144 | protein_coding | tolerated(0.35) | benign(0.102) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ANPEP | SNV | Missense_Mutation | rs201704361 | c.583N>T | p.Arg195Cys | p.R195C | P15144 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D5-5539-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fu | PD |
ANPEP | SNV | Missense_Mutation | c.1555G>A | p.Asp519Asn | p.D519N | P15144 | protein_coding | tolerated(0.35) | benign(0.003) | TCGA-DM-A28K-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ANPEP | SNV | Missense_Mutation | rs148047449 | c.940N>A | p.Gly314Ser | p.G314S | P15144 | protein_coding | tolerated(0.06) | possibly_damaging(0.577) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD |
ANPEP | SNV | Missense_Mutation | c.1975N>A | p.Ala659Thr | p.A659T | P15144 | protein_coding | deleterious(0) | possibly_damaging(0.845) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ANPEP | SNV | Missense_Mutation | c.1337N>C | p.Val446Ala | p.V446A | P15144 | protein_coding | tolerated(0.07) | benign(0.196) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ANPEP | SNV | Missense_Mutation | rs769850318 | c.304G>A | p.Val102Ile | p.V102I | P15144 | protein_coding | tolerated(1) | benign(0.01) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ANPEP | SNV | Missense_Mutation | c.1693N>A | p.His565Asn | p.H565N | P15144 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-AG-3878-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ANPEP | SNV | Missense_Mutation | rs774559825 | c.1906N>A | p.Glu636Lys | p.E636K | P15144 | protein_coding | tolerated(0.78) | benign(0.23) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
290 | ANPEP | NEUTRAL ZINC METALLOPEPTIDASE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME, PROTEASE, ENZYME | RECOMBINANT ERYTHROPOIETIN | 15957544 | ||
290 | ANPEP | NEUTRAL ZINC METALLOPEPTIDASE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | CHEMBL2103847 | TOSEDOSTAT | |
290 | ANPEP | NEUTRAL ZINC METALLOPEPTIDASE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 348353628 | ||
290 | ANPEP | NEUTRAL ZINC METALLOPEPTIDASE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME, PROTEASE, ENZYME | CEPHALOSPORINS | 8774083 | ||
290 | ANPEP | NEUTRAL ZINC METALLOPEPTIDASE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME, PROTEASE, ENZYME | CEFADROXIL | CEFADROXIL | 8774083 | |
290 | ANPEP | NEUTRAL ZINC METALLOPEPTIDASE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 315661176 | ||
290 | ANPEP | NEUTRAL ZINC METALLOPEPTIDASE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME, PROTEASE, ENZYME | ZINC SULFATE | 14568236 | ||
290 | ANPEP | NEUTRAL ZINC METALLOPEPTIDASE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 348353627 | ||
290 | ANPEP | NEUTRAL ZINC METALLOPEPTIDASE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 252166766 | ||
290 | ANPEP | NEUTRAL ZINC METALLOPEPTIDASE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME, PROTEASE, ENZYME | TRANSFORMING GROWTH FACTOR | 15138629 |
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