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Gene: ANP32A |
Gene summary for ANP32A |
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Gene information | Species | Human | Gene symbol | ANP32A | Gene ID | 8125 |
Gene name | acidic nuclear phosphoprotein 32 family member A | |
Gene Alias | C15orf1 | |
Cytomap | 15q23 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | P39687 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8125 | ANP32A | HTA11_78_2000001011 | Human | Colorectum | AD | 3.99e-02 | 4.15e-01 | -0.1088 |
8125 | ANP32A | HTA11_347_2000001011 | Human | Colorectum | AD | 1.56e-17 | 6.30e-01 | -0.1954 |
8125 | ANP32A | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.24e-03 | 4.12e-01 | -0.059 |
8125 | ANP32A | HTA11_6801_2000001011 | Human | Colorectum | SER | 3.00e-02 | 6.98e-01 | 0.0171 |
8125 | ANP32A | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.59e-03 | 4.25e-01 | 0.294 |
8125 | ANP32A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.39e-07 | 6.14e-01 | 0.281 |
8125 | ANP32A | A015-C-203 | Human | Colorectum | FAP | 6.59e-10 | -9.92e-02 | -0.1294 |
8125 | ANP32A | A014-C-040 | Human | Colorectum | FAP | 3.45e-02 | -3.21e-01 | -0.1184 |
8125 | ANP32A | A002-C-201 | Human | Colorectum | FAP | 1.09e-04 | -1.77e-01 | 0.0324 |
8125 | ANP32A | A001-C-119 | Human | Colorectum | FAP | 2.04e-03 | -2.61e-01 | -0.1557 |
8125 | ANP32A | A001-C-108 | Human | Colorectum | FAP | 4.42e-06 | -1.61e-01 | -0.0272 |
8125 | ANP32A | A002-C-205 | Human | Colorectum | FAP | 6.82e-07 | -1.98e-01 | -0.1236 |
8125 | ANP32A | A015-C-005 | Human | Colorectum | FAP | 3.37e-03 | -2.26e-01 | -0.0336 |
8125 | ANP32A | A015-C-006 | Human | Colorectum | FAP | 8.80e-04 | -2.22e-01 | -0.0994 |
8125 | ANP32A | A015-C-106 | Human | Colorectum | FAP | 6.05e-05 | -1.56e-01 | -0.0511 |
8125 | ANP32A | A002-C-114 | Human | Colorectum | FAP | 6.43e-05 | -1.70e-01 | -0.1561 |
8125 | ANP32A | A015-C-104 | Human | Colorectum | FAP | 4.64e-09 | -1.78e-01 | -0.1899 |
8125 | ANP32A | A001-C-014 | Human | Colorectum | FAP | 1.84e-05 | -1.90e-01 | 0.0135 |
8125 | ANP32A | A002-C-016 | Human | Colorectum | FAP | 2.82e-05 | -1.28e-01 | 0.0521 |
8125 | ANP32A | A015-C-002 | Human | Colorectum | FAP | 2.91e-02 | -1.99e-01 | -0.0763 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006913 | Colorectum | AD | nucleocytoplasmic transport | 102/3918 | 301/18723 | 1.00e-07 | 4.85e-06 | 102 |
GO:0051169 | Colorectum | AD | nuclear transport | 102/3918 | 301/18723 | 1.00e-07 | 4.85e-06 | 102 |
GO:00069131 | Colorectum | SER | nucleocytoplasmic transport | 77/2897 | 301/18723 | 3.39e-06 | 1.32e-04 | 77 |
GO:00511691 | Colorectum | SER | nuclear transport | 77/2897 | 301/18723 | 3.39e-06 | 1.32e-04 | 77 |
GO:00069132 | Colorectum | MSS | nucleocytoplasmic transport | 99/3467 | 301/18723 | 1.35e-09 | 1.03e-07 | 99 |
GO:00511692 | Colorectum | MSS | nuclear transport | 99/3467 | 301/18723 | 1.35e-09 | 1.03e-07 | 99 |
GO:00069134 | Colorectum | FAP | nucleocytoplasmic transport | 77/2622 | 301/18723 | 6.15e-08 | 4.54e-06 | 77 |
GO:00511694 | Colorectum | FAP | nuclear transport | 77/2622 | 301/18723 | 6.15e-08 | 4.54e-06 | 77 |
GO:00069135 | Colorectum | CRC | nucleocytoplasmic transport | 57/2078 | 301/18723 | 3.71e-05 | 9.18e-04 | 57 |
GO:00511695 | Colorectum | CRC | nuclear transport | 57/2078 | 301/18723 | 3.71e-05 | 9.18e-04 | 57 |
GO:000691310 | Endometrium | AEH | nucleocytoplasmic transport | 54/2100 | 301/18723 | 3.24e-04 | 3.62e-03 | 54 |
GO:005116910 | Endometrium | AEH | nuclear transport | 54/2100 | 301/18723 | 3.24e-04 | 3.62e-03 | 54 |
GO:000691314 | Endometrium | EEC | nucleocytoplasmic transport | 59/2168 | 301/18723 | 3.31e-05 | 5.65e-04 | 59 |
GO:005116914 | Endometrium | EEC | nuclear transport | 59/2168 | 301/18723 | 3.31e-05 | 5.65e-04 | 59 |
GO:0006913110 | Esophagus | ESCC | nucleocytoplasmic transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051169110 | Esophagus | ESCC | nuclear transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:000691312 | Liver | Cirrhotic | nucleocytoplasmic transport | 118/4634 | 301/18723 | 1.71e-08 | 6.27e-07 | 118 |
GO:005116912 | Liver | Cirrhotic | nuclear transport | 118/4634 | 301/18723 | 1.71e-08 | 6.27e-07 | 118 |
GO:000691322 | Liver | HCC | nucleocytoplasmic transport | 208/7958 | 301/18723 | 5.51e-21 | 8.12e-19 | 208 |
GO:005116922 | Liver | HCC | nuclear transport | 208/7958 | 301/18723 | 5.51e-21 | 8.12e-19 | 208 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANP32A | SNV | Missense_Mutation | c.76N>C | p.Asn26His | p.N26H | P39687 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-HU-A4GF-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ANP32A | SNV | Missense_Mutation | c.673G>A | p.Glu225Lys | p.E225K | P39687 | protein_coding | tolerated(0.09) | benign(0.187) | TCGA-DJ-A2PV-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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