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Gene: ANKRD28 |
Gene summary for ANKRD28 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ANKRD28 | Gene ID | 23243 |
Gene name | ankyrin repeat domain 28 | |
Gene Alias | CFAP79 | |
Cytomap | 3p25.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | O15084 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23243 | ANKRD28 | CCI_2 | Human | Cervix | CC | 1.23e-09 | 1.15e+00 | 0.5249 |
23243 | ANKRD28 | CCI_3 | Human | Cervix | CC | 9.32e-06 | 7.49e-01 | 0.516 |
23243 | ANKRD28 | Tumor | Human | Cervix | CC | 8.02e-04 | -2.80e-01 | 0.1241 |
23243 | ANKRD28 | sample3 | Human | Cervix | CC | 3.48e-02 | -2.45e-01 | 0.1387 |
23243 | ANKRD28 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.20e-28 | -7.52e-01 | 0.0155 |
23243 | ANKRD28 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.02e-08 | -6.42e-01 | -0.1808 |
23243 | ANKRD28 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.18e-03 | -7.70e-01 | 0.0216 |
23243 | ANKRD28 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.30e-05 | -4.32e-01 | -0.0811 |
23243 | ANKRD28 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.19e-02 | -6.84e-01 | -0.2196 |
23243 | ANKRD28 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.99e-09 | -6.92e-01 | -0.1207 |
23243 | ANKRD28 | HTA11_83_2000001011 | Human | Colorectum | SER | 7.76e-03 | -5.00e-01 | -0.1526 |
23243 | ANKRD28 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.16e-25 | -5.64e-01 | -0.1464 |
23243 | ANKRD28 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.01e-14 | -4.87e-01 | -0.1001 |
23243 | ANKRD28 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.03e-05 | -7.62e-01 | -0.2061 |
23243 | ANKRD28 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.28e-04 | -7.99e-01 | -0.1462 |
23243 | ANKRD28 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.21e-05 | -6.66e-01 | -0.0179 |
23243 | ANKRD28 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.77e-21 | -7.49e-01 | 0.096 |
23243 | ANKRD28 | HTA11_4255_2000001011 | Human | Colorectum | SER | 8.14e-04 | -7.13e-01 | 0.0446 |
23243 | ANKRD28 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.34e-02 | -5.67e-01 | 0.0131 |
23243 | ANKRD28 | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.78e-02 | -5.68e-01 | -0.0177 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANKRD28 | SNV | Missense_Mutation | novel | c.2081N>T | p.Ala694Val | p.A694V | O15084 | protein_coding | tolerated(0.45) | benign(0.027) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKRD28 | SNV | Missense_Mutation | c.2994T>G | p.Asn998Lys | p.N998K | O15084 | protein_coding | tolerated(0.55) | benign(0.021) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ANKRD28 | SNV | Missense_Mutation | rs371624017 | c.523N>T | p.Arg175Cys | p.R175C | O15084 | protein_coding | deleterious(0.04) | probably_damaging(0.987) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ANKRD28 | SNV | Missense_Mutation | rs758460133 | c.661N>A | p.Val221Ile | p.V221I | O15084 | protein_coding | tolerated(0.09) | benign(0.058) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ANKRD28 | SNV | Missense_Mutation | c.1831G>A | p.Val611Ile | p.V611I | O15084 | protein_coding | tolerated(0.15) | benign(0.081) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ANKRD28 | SNV | Missense_Mutation | rs772429036 | c.2504A>G | p.His835Arg | p.H835R | O15084 | protein_coding | tolerated(0.09) | benign(0.411) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ANKRD28 | SNV | Missense_Mutation | rs768759447 | c.2894N>T | p.Ala965Val | p.A965V | O15084 | protein_coding | deleterious(0.01) | probably_damaging(0.948) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ANKRD28 | SNV | Missense_Mutation | c.1586C>T | p.Pro529Leu | p.P529L | O15084 | protein_coding | tolerated(0.07) | benign(0.148) | TCGA-AG-3887-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | irinotecan | SD | |
ANKRD28 | SNV | Missense_Mutation | c.482N>T | p.Ser161Phe | p.S161F | O15084 | protein_coding | tolerated(0.08) | possibly_damaging(0.905) | TCGA-EI-6510-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ANKRD28 | deletion | Frame_Shift_Del | c.614delN | p.Lys205SerfsTer14 | p.K205Sfs*14 | O15084 | protein_coding | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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