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Gene: ANKRD13C |
Gene summary for ANKRD13C |
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Gene information | Species | Human | Gene symbol | ANKRD13C | Gene ID | 81573 |
Gene name | ankyrin repeat domain 13C | |
Gene Alias | dJ677H15.3 | |
Cytomap | 1p31.1 | |
Gene Type | protein-coding | GO ID | GO:0006621 | UniProtAcc | Q8N6S4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81573 | ANKRD13C | LZE4T | Human | Esophagus | ESCC | 3.19e-07 | 1.58e-01 | 0.0811 |
81573 | ANKRD13C | LZE7T | Human | Esophagus | ESCC | 5.01e-03 | 1.20e-01 | 0.0667 |
81573 | ANKRD13C | LZE8T | Human | Esophagus | ESCC | 4.00e-04 | 1.07e-01 | 0.067 |
81573 | ANKRD13C | LZE20T | Human | Esophagus | ESCC | 8.50e-03 | 5.94e-02 | 0.0662 |
81573 | ANKRD13C | LZE24T | Human | Esophagus | ESCC | 5.50e-12 | 2.36e-01 | 0.0596 |
81573 | ANKRD13C | P1T-E | Human | Esophagus | ESCC | 2.42e-03 | 1.29e-01 | 0.0875 |
81573 | ANKRD13C | P2T-E | Human | Esophagus | ESCC | 5.22e-19 | 2.92e-01 | 0.1177 |
81573 | ANKRD13C | P4T-E | Human | Esophagus | ESCC | 1.20e-14 | 2.70e-01 | 0.1323 |
81573 | ANKRD13C | P5T-E | Human | Esophagus | ESCC | 4.25e-13 | 1.70e-01 | 0.1327 |
81573 | ANKRD13C | P8T-E | Human | Esophagus | ESCC | 1.11e-09 | 1.73e-01 | 0.0889 |
81573 | ANKRD13C | P9T-E | Human | Esophagus | ESCC | 1.12e-06 | 7.52e-02 | 0.1131 |
81573 | ANKRD13C | P10T-E | Human | Esophagus | ESCC | 1.16e-07 | 2.03e-01 | 0.116 |
81573 | ANKRD13C | P11T-E | Human | Esophagus | ESCC | 1.20e-08 | 2.42e-01 | 0.1426 |
81573 | ANKRD13C | P12T-E | Human | Esophagus | ESCC | 1.69e-17 | 2.11e-01 | 0.1122 |
81573 | ANKRD13C | P15T-E | Human | Esophagus | ESCC | 4.86e-21 | 2.87e-01 | 0.1149 |
81573 | ANKRD13C | P16T-E | Human | Esophagus | ESCC | 3.38e-09 | 1.49e-01 | 0.1153 |
81573 | ANKRD13C | P17T-E | Human | Esophagus | ESCC | 1.09e-07 | 1.44e-01 | 0.1278 |
81573 | ANKRD13C | P19T-E | Human | Esophagus | ESCC | 2.85e-02 | 2.51e-01 | 0.1662 |
81573 | ANKRD13C | P20T-E | Human | Esophagus | ESCC | 1.28e-15 | 2.91e-01 | 0.1124 |
81573 | ANKRD13C | P21T-E | Human | Esophagus | ESCC | 8.27e-19 | 2.73e-01 | 0.1617 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0045185111 | Esophagus | ESCC | maintenance of protein location | 71/8552 | 94/18723 | 3.41e-09 | 7.24e-08 | 71 |
GO:0051235110 | Esophagus | ESCC | maintenance of location | 200/8552 | 327/18723 | 1.01e-08 | 2.02e-07 | 200 |
GO:0032507110 | Esophagus | ESCC | maintenance of protein location in cell | 52/8552 | 65/18723 | 1.41e-08 | 2.77e-07 | 52 |
GO:007259517 | Esophagus | ESCC | maintenance of protein localization in organelle | 36/8552 | 42/18723 | 8.46e-08 | 1.44e-06 | 36 |
GO:007097218 | Esophagus | ESCC | protein localization to endoplasmic reticulum | 52/8552 | 74/18723 | 1.58e-05 | 1.42e-04 | 52 |
GO:0051651111 | Esophagus | ESCC | maintenance of location in cell | 126/8552 | 214/18723 | 6.57e-05 | 5.00e-04 | 126 |
GO:20002093 | Esophagus | ESCC | regulation of anoikis | 20/8552 | 24/18723 | 1.69e-04 | 1.11e-03 | 20 |
GO:00432761 | Esophagus | ESCC | anoikis | 26/8552 | 34/18723 | 2.53e-04 | 1.55e-03 | 26 |
GO:00354377 | Esophagus | ESCC | maintenance of protein localization in endoplasmic reticulum | 11/8552 | 14/18723 | 1.30e-02 | 4.27e-02 | 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANKRD13C | SNV | Missense_Mutation | novel | c.32G>T | p.Arg11Met | p.R11M | Q8N6S4 | protein_coding | deleterious_low_confidence(0) | benign(0.365) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
ANKRD13C | SNV | Missense_Mutation | rs774093011 | c.635N>A | p.Arg212Gln | p.R212Q | Q8N6S4 | protein_coding | tolerated(0.13) | possibly_damaging(0.895) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ANKRD13C | SNV | Missense_Mutation | rs779302047 | c.1552G>A | p.Asp518Asn | p.D518N | Q8N6S4 | protein_coding | tolerated(0.21) | benign(0.037) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKRD13C | SNV | Missense_Mutation | novel | c.1040N>A | p.Arg347Gln | p.R347Q | Q8N6S4 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKRD13C | SNV | Missense_Mutation | c.1502N>A | p.Pro501His | p.P501H | Q8N6S4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BS-A0UL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ANKRD13C | SNV | Missense_Mutation | novel | c.970N>A | p.Asp324Asn | p.D324N | Q8N6S4 | protein_coding | deleterious(0.05) | possibly_damaging(0.679) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ANKRD13C | SNV | Missense_Mutation | novel | c.1417G>T | p.Val473Leu | p.V473L | Q8N6S4 | protein_coding | tolerated(0.19) | benign(0.01) | TCGA-DF-A2KZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ANKRD13C | SNV | Missense_Mutation | novel | c.990N>T | p.Leu330Phe | p.L330F | Q8N6S4 | protein_coding | deleterious(0.04) | possibly_damaging(0.574) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
ANKRD13C | SNV | Missense_Mutation | novel | c.766N>T | p.Ile256Phe | p.I256F | Q8N6S4 | protein_coding | tolerated(0.11) | benign(0.067) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
ANKRD13C | SNV | Missense_Mutation | novel | c.1489N>C | p.Lys497Gln | p.K497Q | Q8N6S4 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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