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Gene: ANGPTL2 |
Gene summary for ANGPTL2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ANGPTL2 | Gene ID | 23452 |
Gene name | angiopoietin like 2 | |
Gene Alias | ARP2 | |
Cytomap | 9q33.3 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | A0A024R868 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23452 | ANGPTL2 | P2T-E | Human | Esophagus | ESCC | 7.00e-10 | 1.13e-01 | 0.1177 |
23452 | ANGPTL2 | P8T-E | Human | Esophagus | ESCC | 8.08e-25 | 8.48e-01 | 0.0889 |
23452 | ANGPTL2 | P10T-E | Human | Esophagus | ESCC | 1.03e-06 | 2.30e-01 | 0.116 |
23452 | ANGPTL2 | P11T-E | Human | Esophagus | ESCC | 1.40e-05 | 4.78e-01 | 0.1426 |
23452 | ANGPTL2 | P12T-E | Human | Esophagus | ESCC | 1.61e-02 | 1.06e-01 | 0.1122 |
23452 | ANGPTL2 | P21T-E | Human | Esophagus | ESCC | 8.18e-15 | 4.83e-01 | 0.1617 |
23452 | ANGPTL2 | P27T-E | Human | Esophagus | ESCC | 1.32e-05 | 1.24e-01 | 0.1055 |
23452 | ANGPTL2 | P44T-E | Human | Esophagus | ESCC | 2.54e-02 | 4.98e-01 | 0.1096 |
23452 | ANGPTL2 | P54T-E | Human | Esophagus | ESCC | 7.11e-05 | 7.33e-02 | 0.0975 |
23452 | ANGPTL2 | P61T-E | Human | Esophagus | ESCC | 2.92e-04 | 4.89e-02 | 0.099 |
23452 | ANGPTL2 | P79T-E | Human | Esophagus | ESCC | 3.44e-02 | 1.32e-01 | 0.1154 |
23452 | ANGPTL2 | P128T-E | Human | Esophagus | ESCC | 4.45e-05 | 5.52e-01 | 0.1241 |
23452 | ANGPTL2 | S014 | Human | Liver | HCC | 1.78e-14 | 6.18e-01 | 0.2254 |
23452 | ANGPTL2 | S015 | Human | Liver | HCC | 8.11e-10 | 6.13e-01 | 0.2375 |
23452 | ANGPTL2 | S016 | Human | Liver | HCC | 1.96e-27 | 8.10e-01 | 0.2243 |
23452 | ANGPTL2 | male-WTA | Human | Thyroid | PTC | 2.56e-04 | 5.79e-02 | 0.1037 |
23452 | ANGPTL2 | PTC06 | Human | Thyroid | PTC | 4.12e-03 | 1.34e-01 | 0.2057 |
23452 | ANGPTL2 | ATC09 | Human | Thyroid | ATC | 3.24e-14 | 5.89e-01 | 0.2871 |
23452 | ANGPTL2 | ATC12 | Human | Thyroid | ATC | 3.36e-25 | 6.12e-01 | 0.34 |
23452 | ANGPTL2 | ATC13 | Human | Thyroid | ATC | 4.57e-72 | 2.10e+00 | 0.34 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
ANGPTL2 | ITGA5_ITGB1 | ANGPTL2_ITGA5_ITGB1 | ANGPTL | Breast | ADJ |
ANGPTL2 | ITGA5_ITGB1 | ANGPTL2_ITGA5_ITGB1 | ANGPTL | Breast | DCIS |
ANGPTL2 | TLR4 | ANGPTL2_TLR4 | ANGPTL | Breast | DCIS |
ANGPTL2 | LILRB3 | ANGPTL2_PIRB | ANGPTL | Breast | DCIS |
ANGPTL2 | ITGA5_ITGB1 | ANGPTL2_ITGA5_ITGB1 | ANGPTL | Breast | Healthy |
ANGPTL2 | ITGA5_ITGB1 | ANGPTL2_ITGA5_ITGB1 | ANGPTL | Breast | IDC |
ANGPTL2 | TLR4 | ANGPTL2_TLR4 | ANGPTL | Breast | IDC |
ANGPTL2 | LILRB3 | ANGPTL2_PIRB | ANGPTL | Breast | IDC |
ANGPTL2 | ITGA5_ITGB1 | ANGPTL2_ITGA5_ITGB1 | ANGPTL | Breast | Precancer |
ANGPTL2 | ITGA5_ITGB1 | ANGPTL2_ITGA5_ITGB1 | ANGPTL | Cervix | ADJ |
ANGPTL2 | TLR4 | ANGPTL2_TLR4 | ANGPTL | Cervix | ADJ |
ANGPTL2 | ITGA5_ITGB1 | ANGPTL2_ITGA5_ITGB1 | ANGPTL | Cervix | CC |
ANGPTL2 | TLR4 | ANGPTL2_TLR4 | ANGPTL | Cervix | CC |
ANGPTL2 | LILRB3 | ANGPTL2_PIRB | ANGPTL | Cervix | CC |
ANGPTL2 | ITGA5_ITGB1 | ANGPTL2_ITGA5_ITGB1 | ANGPTL | Cervix | Precancer |
ANGPTL2 | TLR4 | ANGPTL2_TLR4 | ANGPTL | Cervix | Precancer |
ANGPTL2 | LILRB3 | ANGPTL2_PIRB | ANGPTL | Cervix | Precancer |
ANGPTL2 | ITGA5_ITGB1 | ANGPTL2_ITGA5_ITGB1 | ANGPTL | CRC | MSI-H |
ANGPTL2 | ITGA5_ITGB1 | ANGPTL2_ITGA5_ITGB1 | ANGPTL | CRC | MSS |
ANGPTL2 | ITGA5_ITGB1 | ANGPTL2_ITGA5_ITGB1 | ANGPTL | Endometrium | AEH |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANGPTL2 | SNV | Missense_Mutation | rs200073434 | c.1363N>A | p.Gly455Arg | p.G455R | Q9UKU9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ANGPTL2 | SNV | Missense_Mutation | rs770228069 | c.455N>T | p.Ala152Val | p.A152V | Q9UKU9 | protein_coding | tolerated(0.08) | possibly_damaging(0.734) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ANGPTL2 | SNV | Missense_Mutation | c.382N>T | p.Arg128Cys | p.R128C | Q9UKU9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
ANGPTL2 | SNV | Missense_Mutation | rs764497308 | c.1196G>A | p.Arg399His | p.R399H | Q9UKU9 | protein_coding | tolerated(0.35) | benign(0.168) | TCGA-AX-A1CA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
ANGPTL2 | SNV | Missense_Mutation | rs776774899 | c.1324N>A | p.Ala442Thr | p.A442T | Q9UKU9 | protein_coding | deleterious(0.02) | benign(0.318) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
ANGPTL2 | SNV | Missense_Mutation | novel | c.1153N>T | p.Arg385Cys | p.R385C | Q9UKU9 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
ANGPTL2 | SNV | Missense_Mutation | novel | c.499N>T | p.Ala167Ser | p.A167S | Q9UKU9 | protein_coding | tolerated(0.49) | benign(0.003) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
ANGPTL2 | SNV | Missense_Mutation | novel | c.725T>C | p.Ile242Thr | p.I242T | Q9UKU9 | protein_coding | tolerated(0.26) | probably_damaging(0.954) | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANGPTL2 | SNV | Missense_Mutation | c.1238N>A | p.Gly413Asp | p.G413D | Q9UKU9 | protein_coding | tolerated(0.68) | probably_damaging(0.997) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ANGPTL2 | SNV | Missense_Mutation | rs568583240 | c.445C>T | p.Arg149Trp | p.R149W | Q9UKU9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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