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Gene: ALKBH3 |
Gene summary for ALKBH3 |
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Gene information | Species | Human | Gene symbol | ALKBH3 | Gene ID | 221120 |
Gene name | alkB homolog 3, alpha-ketoglutarate dependent dioxygenase | |
Gene Alias | ABH3 | |
Cytomap | 11p11.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q96Q83 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
221120 | ALKBH3 | LZE4T | Human | Esophagus | ESCC | 5.59e-07 | 2.28e-01 | 0.0811 |
221120 | ALKBH3 | LZE7T | Human | Esophagus | ESCC | 3.30e-04 | 2.99e-01 | 0.0667 |
221120 | ALKBH3 | LZE22T | Human | Esophagus | ESCC | 2.29e-02 | 1.70e-01 | 0.068 |
221120 | ALKBH3 | LZE24T | Human | Esophagus | ESCC | 1.92e-17 | 4.15e-01 | 0.0596 |
221120 | ALKBH3 | LZE6T | Human | Esophagus | ESCC | 4.68e-03 | 1.99e-01 | 0.0845 |
221120 | ALKBH3 | P1T-E | Human | Esophagus | ESCC | 1.31e-03 | 2.61e-01 | 0.0875 |
221120 | ALKBH3 | P2T-E | Human | Esophagus | ESCC | 1.51e-24 | 4.51e-01 | 0.1177 |
221120 | ALKBH3 | P4T-E | Human | Esophagus | ESCC | 5.80e-14 | 2.45e-01 | 0.1323 |
221120 | ALKBH3 | P5T-E | Human | Esophagus | ESCC | 1.10e-02 | 7.12e-02 | 0.1327 |
221120 | ALKBH3 | P8T-E | Human | Esophagus | ESCC | 7.33e-20 | 3.43e-01 | 0.0889 |
221120 | ALKBH3 | P9T-E | Human | Esophagus | ESCC | 3.09e-07 | 1.82e-01 | 0.1131 |
221120 | ALKBH3 | P10T-E | Human | Esophagus | ESCC | 1.98e-21 | 3.25e-01 | 0.116 |
221120 | ALKBH3 | P11T-E | Human | Esophagus | ESCC | 3.15e-13 | 4.86e-01 | 0.1426 |
221120 | ALKBH3 | P12T-E | Human | Esophagus | ESCC | 1.44e-23 | 2.98e-01 | 0.1122 |
221120 | ALKBH3 | P15T-E | Human | Esophagus | ESCC | 1.04e-19 | 2.63e-01 | 0.1149 |
221120 | ALKBH3 | P16T-E | Human | Esophagus | ESCC | 6.12e-20 | 3.41e-01 | 0.1153 |
221120 | ALKBH3 | P17T-E | Human | Esophagus | ESCC | 1.16e-11 | 3.90e-01 | 0.1278 |
221120 | ALKBH3 | P19T-E | Human | Esophagus | ESCC | 7.89e-07 | 4.39e-01 | 0.1662 |
221120 | ALKBH3 | P20T-E | Human | Esophagus | ESCC | 7.97e-30 | 4.80e-01 | 0.1124 |
221120 | ALKBH3 | P21T-E | Human | Esophagus | ESCC | 4.42e-29 | 5.86e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:0006304 | Esophagus | ESCC | DNA modification | 68/8552 | 120/18723 | 9.95e-03 | 3.42e-02 | 68 |
GO:00094511 | Oral cavity | OSCC | RNA modification | 95/7305 | 167/18723 | 2.05e-06 | 2.62e-05 | 95 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ALKBH3 | SNV | Missense_Mutation | rs372711510 | c.545N>A | p.Arg182His | p.R182H | Q96Q83 | protein_coding | deleterious(0) | probably_damaging(0.929) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ALKBH3 | SNV | Missense_Mutation | novel | c.626N>C | p.Phe209Ser | p.F209S | Q96Q83 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ALKBH3 | SNV | Missense_Mutation | c.547N>T | p.Asn183Tyr | p.N183Y | Q96Q83 | protein_coding | deleterious(0) | possibly_damaging(0.583) | TCGA-DD-A11C-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ALKBH3 | SNV | Missense_Mutation | c.732G>C | p.Leu244Phe | p.L244F | Q96Q83 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-44-3918-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
ALKBH3 | SNV | Missense_Mutation | novel | c.782N>G | p.Lys261Arg | p.K261R | Q96Q83 | protein_coding | tolerated(0.11) | benign(0.075) | TCGA-55-1596-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR |
ALKBH3 | SNV | Missense_Mutation | c.718G>T | p.Asp240Tyr | p.D240Y | Q96Q83 | protein_coding | deleterious(0.01) | possibly_damaging(0.796) | TCGA-69-7765-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | SD | |
ALKBH3 | SNV | Missense_Mutation | c.499N>C | p.Glu167Gln | p.E167Q | Q96Q83 | protein_coding | tolerated(0.25) | benign(0.006) | TCGA-18-4083-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD | |
ALKBH3 | SNV | Missense_Mutation | novel | c.701N>T | p.Arg234Ile | p.R234I | Q96Q83 | protein_coding | deleterious(0.04) | benign(0.069) | TCGA-56-8201-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ALKBH3 | SNV | Missense_Mutation | c.638N>T | p.Arg213Leu | p.R213L | Q96Q83 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-56-8625-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
ALKBH3 | SNV | Missense_Mutation | novel | c.295G>C | p.Val99Leu | p.V99L | Q96Q83 | protein_coding | tolerated(0.33) | benign(0) | TCGA-66-2791-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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