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Gene: AKR7A2 |
Gene summary for AKR7A2 |
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Gene information | Species | Human | Gene symbol | AKR7A2 | Gene ID | 8574 |
Gene name | aldo-keto reductase family 7 member A2 | |
Gene Alias | AFAR | |
Cytomap | 1p36.13 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | B4DZX4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8574 | AKR7A2 | GSM4909281 | Human | Breast | IDC | 8.11e-05 | 1.51e-01 | 0.21 |
8574 | AKR7A2 | GSM4909282 | Human | Breast | IDC | 2.08e-16 | 3.95e-01 | -0.0288 |
8574 | AKR7A2 | GSM4909288 | Human | Breast | IDC | 2.72e-02 | 4.07e-01 | 0.0988 |
8574 | AKR7A2 | GSM4909291 | Human | Breast | IDC | 1.78e-04 | 3.72e-01 | 0.1753 |
8574 | AKR7A2 | GSM4909293 | Human | Breast | IDC | 2.10e-05 | 1.85e-01 | 0.1581 |
8574 | AKR7A2 | GSM4909294 | Human | Breast | IDC | 1.32e-11 | 3.69e-01 | 0.2022 |
8574 | AKR7A2 | GSM4909298 | Human | Breast | IDC | 5.58e-05 | 1.15e-01 | 0.1551 |
8574 | AKR7A2 | GSM4909304 | Human | Breast | IDC | 4.08e-44 | 6.82e-01 | 0.1636 |
8574 | AKR7A2 | GSM4909305 | Human | Breast | IDC | 2.15e-03 | 2.86e-01 | 0.0436 |
8574 | AKR7A2 | GSM4909306 | Human | Breast | IDC | 5.10e-09 | 3.10e-01 | 0.1564 |
8574 | AKR7A2 | GSM4909318 | Human | Breast | IDC | 8.68e-06 | 5.27e-01 | 0.2031 |
8574 | AKR7A2 | GSM4909319 | Human | Breast | IDC | 7.36e-17 | 1.94e-01 | 0.1563 |
8574 | AKR7A2 | brca2 | Human | Breast | Precancer | 1.37e-03 | 6.67e-02 | -0.024 |
8574 | AKR7A2 | brca3 | Human | Breast | Precancer | 1.46e-02 | 9.31e-02 | -0.0263 |
8574 | AKR7A2 | NCCBC2 | Human | Breast | DCIS | 1.91e-02 | 1.46e-01 | 0.1554 |
8574 | AKR7A2 | P1 | Human | Breast | IDC | 2.98e-03 | -5.54e-02 | 0.1527 |
8574 | AKR7A2 | DCIS2 | Human | Breast | DCIS | 9.30e-49 | 7.53e-02 | 0.0085 |
8574 | AKR7A2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.06e-04 | 2.54e-01 | 0.0155 |
8574 | AKR7A2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.21e-12 | 6.02e-01 | -0.1808 |
8574 | AKR7A2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.14e-08 | 5.49e-01 | -0.0811 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00060918 | Breast | Precancer | generation of precursor metabolites and energy | 94/1080 | 490/18723 | 1.54e-25 | 1.64e-22 | 94 |
GO:00229008 | Breast | Precancer | electron transport chain | 42/1080 | 175/18723 | 1.37e-15 | 4.59e-13 | 42 |
GO:000609113 | Breast | IDC | generation of precursor metabolites and energy | 103/1434 | 490/18723 | 1.53e-21 | 1.74e-18 | 103 |
GO:002290013 | Breast | IDC | electron transport chain | 51/1434 | 175/18723 | 2.23e-17 | 8.43e-15 | 51 |
GO:000609123 | Breast | DCIS | generation of precursor metabolites and energy | 103/1390 | 490/18723 | 1.46e-22 | 1.65e-19 | 103 |
GO:002290023 | Breast | DCIS | electron transport chain | 51/1390 | 175/18723 | 6.01e-18 | 2.62e-15 | 51 |
GO:0006091 | Colorectum | AD | generation of precursor metabolites and energy | 209/3918 | 490/18723 | 3.17e-28 | 6.61e-25 | 209 |
GO:0022900 | Colorectum | AD | electron transport chain | 89/3918 | 175/18723 | 1.42e-18 | 8.91e-16 | 89 |
GO:0006066 | Colorectum | AD | alcohol metabolic process | 106/3918 | 353/18723 | 3.02e-05 | 5.57e-04 | 106 |
GO:0034308 | Colorectum | AD | primary alcohol metabolic process | 35/3918 | 102/18723 | 1.16e-03 | 1.05e-02 | 35 |
GO:0006081 | Colorectum | AD | cellular aldehyde metabolic process | 22/3918 | 60/18723 | 3.64e-03 | 2.60e-02 | 22 |
GO:00060911 | Colorectum | SER | generation of precursor metabolites and energy | 168/2897 | 490/18723 | 1.39e-25 | 1.70e-22 | 168 |
GO:00229001 | Colorectum | SER | electron transport chain | 77/2897 | 175/18723 | 1.77e-19 | 1.36e-16 | 77 |
GO:00060661 | Colorectum | SER | alcohol metabolic process | 79/2897 | 353/18723 | 3.50e-04 | 5.50e-03 | 79 |
GO:00343081 | Colorectum | SER | primary alcohol metabolic process | 26/2897 | 102/18723 | 5.87e-03 | 4.29e-02 | 26 |
GO:00060912 | Colorectum | MSS | generation of precursor metabolites and energy | 186/3467 | 490/18723 | 1.14e-24 | 2.15e-21 | 186 |
GO:00229002 | Colorectum | MSS | electron transport chain | 83/3467 | 175/18723 | 2.06e-18 | 1.17e-15 | 83 |
GO:00060662 | Colorectum | MSS | alcohol metabolic process | 92/3467 | 353/18723 | 2.57e-04 | 3.46e-03 | 92 |
GO:00060811 | Colorectum | MSS | cellular aldehyde metabolic process | 21/3467 | 60/18723 | 1.81e-03 | 1.60e-02 | 21 |
GO:00229003 | Colorectum | MSI-H | electron transport chain | 52/1319 | 175/18723 | 1.13e-19 | 5.21e-17 | 52 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AKR7A2 | SNV | Missense_Mutation | novel | c.928N>A | p.Gly310Arg | p.G310R | O43488 | protein_coding | deleterious(0.03) | possibly_damaging(0.744) | TCGA-D6-6516-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
AKR7A2 | SNV | Missense_Mutation | novel | c.821C>T | p.Ala274Val | p.A274V | O43488 | protein_coding | tolerated(0.08) | benign(0.275) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
AKR7A2 | SNV | Missense_Mutation | c.674N>G | p.Tyr225Cys | p.Y225C | O43488 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
AKR7A2 | SNV | Missense_Mutation | c.514N>G | p.Asn172Asp | p.N172D | O43488 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-8372-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR | |
AKR7A2 | SNV | Missense_Mutation | rs199970984 | c.890N>A | p.Arg297Gln | p.R297Q | O43488 | protein_coding | deleterious(0.03) | possibly_damaging(0.605) | TCGA-CD-A4MI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
AKR7A2 | SNV | Missense_Mutation | c.268G>T | p.Gly90Trp | p.G90W | O43488 | protein_coding | deleterious(0) | probably_damaging(0.927) | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD | |
AKR7A2 | SNV | Missense_Mutation | c.982N>A | p.Ala328Thr | p.A328T | O43488 | protein_coding | tolerated(0.2) | benign(0.04) | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
AKR7A2 | SNV | Missense_Mutation | novel | c.710N>G | p.Tyr237Cys | p.Y237C | O43488 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
AKR7A2 | SNV | Missense_Mutation | rs770904476 | c.563N>G | p.Asn188Ser | p.N188S | O43488 | protein_coding | deleterious(0.01) | benign(0.232) | TCGA-VQ-AA68-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | CR |
AKR7A2 | SNV | Missense_Mutation | rs775556235 | c.862N>A | p.Ala288Thr | p.A288T | O43488 | protein_coding | tolerated(0.39) | benign(0.003) | TCGA-VQ-AA6D-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8574 | AKR7A2 | DRUGGABLE GENOME, ENZYME | daunorubicin | DAUNORUBICIN | 20837989 | |
8574 | AKR7A2 | DRUGGABLE GENOME, ENZYME | doxorubicin | DOXORUBICIN | 20837989 |
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