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Gene: AHCTF1 |
Gene summary for AHCTF1 |
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Gene information | Species | Human | Gene symbol | AHCTF1 | Gene ID | 25909 |
Gene name | AT-hook containing transcription factor 1 | |
Gene Alias | ELYS | |
Cytomap | 1q44 | |
Gene Type | protein-coding | GO ID | GO:0000910 | UniProtAcc | Q8WYP5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25909 | AHCTF1 | CCI_1 | Human | Cervix | CC | 1.88e-05 | 7.08e-01 | 0.528 |
25909 | AHCTF1 | CCI_2 | Human | Cervix | CC | 1.08e-04 | 8.04e-01 | 0.5249 |
25909 | AHCTF1 | CCI_3 | Human | Cervix | CC | 4.71e-06 | 7.70e-01 | 0.516 |
25909 | AHCTF1 | LZE2T | Human | Esophagus | ESCC | 1.10e-03 | 6.20e-01 | 0.082 |
25909 | AHCTF1 | LZE4T | Human | Esophagus | ESCC | 4.17e-06 | 2.32e-01 | 0.0811 |
25909 | AHCTF1 | LZE5T | Human | Esophagus | ESCC | 6.71e-03 | 1.78e-01 | 0.0514 |
25909 | AHCTF1 | LZE7T | Human | Esophagus | ESCC | 2.42e-07 | 6.41e-01 | 0.0667 |
25909 | AHCTF1 | LZE8T | Human | Esophagus | ESCC | 3.87e-05 | 4.30e-02 | 0.067 |
25909 | AHCTF1 | LZE20T | Human | Esophagus | ESCC | 1.60e-02 | -4.27e-03 | 0.0662 |
25909 | AHCTF1 | LZE22T | Human | Esophagus | ESCC | 1.84e-03 | 2.83e-01 | 0.068 |
25909 | AHCTF1 | LZE24T | Human | Esophagus | ESCC | 6.04e-04 | 2.87e-01 | 0.0596 |
25909 | AHCTF1 | P1T-E | Human | Esophagus | ESCC | 5.65e-04 | 2.74e-01 | 0.0875 |
25909 | AHCTF1 | P2T-E | Human | Esophagus | ESCC | 7.10e-16 | 3.74e-01 | 0.1177 |
25909 | AHCTF1 | P4T-E | Human | Esophagus | ESCC | 3.32e-09 | 2.74e-01 | 0.1323 |
25909 | AHCTF1 | P5T-E | Human | Esophagus | ESCC | 8.20e-24 | 6.10e-01 | 0.1327 |
25909 | AHCTF1 | P8T-E | Human | Esophagus | ESCC | 1.07e-12 | 1.89e-01 | 0.0889 |
25909 | AHCTF1 | P9T-E | Human | Esophagus | ESCC | 5.32e-15 | 2.78e-01 | 0.1131 |
25909 | AHCTF1 | P10T-E | Human | Esophagus | ESCC | 4.08e-16 | 2.86e-01 | 0.116 |
25909 | AHCTF1 | P11T-E | Human | Esophagus | ESCC | 1.29e-13 | 3.45e-01 | 0.1426 |
25909 | AHCTF1 | P12T-E | Human | Esophagus | ESCC | 4.76e-22 | 4.74e-01 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00512368 | Cervix | CC | establishment of RNA localization | 39/2311 | 166/18723 | 4.76e-05 | 7.25e-04 | 39 |
GO:00506578 | Cervix | CC | nucleic acid transport | 38/2311 | 163/18723 | 7.06e-05 | 9.85e-04 | 38 |
GO:00506588 | Cervix | CC | RNA transport | 38/2311 | 163/18723 | 7.06e-05 | 9.85e-04 | 38 |
GO:000640310 | Cervix | CC | RNA localization | 43/2311 | 201/18723 | 2.00e-04 | 2.29e-03 | 43 |
GO:00510284 | Cervix | CC | mRNA transport | 31/2311 | 130/18723 | 2.05e-04 | 2.33e-03 | 31 |
GO:00513021 | Cervix | CC | regulation of cell division | 39/2311 | 177/18723 | 2.05e-04 | 2.33e-03 | 39 |
GO:00469312 | Cervix | CC | pore complex assembly | 9/2311 | 20/18723 | 3.06e-04 | 3.27e-03 | 9 |
GO:00009107 | Cervix | CC | cytokinesis | 37/2311 | 173/18723 | 5.40e-04 | 5.23e-03 | 37 |
GO:0032465 | Cervix | CC | regulation of cytokinesis | 22/2311 | 92/18723 | 1.55e-03 | 1.20e-02 | 22 |
GO:00159318 | Cervix | CC | nucleobase-containing compound transport | 43/2311 | 222/18723 | 1.72e-03 | 1.30e-02 | 43 |
GO:00069991 | Cervix | CC | nuclear pore organization | 6/2311 | 14/18723 | 4.36e-03 | 2.67e-02 | 6 |
GO:0006403110 | Esophagus | ESCC | RNA localization | 166/8552 | 201/18723 | 1.95e-27 | 6.18e-25 | 166 |
GO:005123617 | Esophagus | ESCC | establishment of RNA localization | 134/8552 | 166/18723 | 1.23e-20 | 1.81e-18 | 134 |
GO:005102815 | Esophagus | ESCC | mRNA transport | 110/8552 | 130/18723 | 2.76e-20 | 3.80e-18 | 110 |
GO:005065717 | Esophagus | ESCC | nucleic acid transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
GO:005065817 | Esophagus | ESCC | RNA transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
GO:001593117 | Esophagus | ESCC | nucleobase-containing compound transport | 162/8552 | 222/18723 | 9.87e-17 | 7.93e-15 | 162 |
GO:000699713 | Esophagus | ESCC | nucleus organization | 96/8552 | 133/18723 | 4.66e-10 | 1.21e-08 | 96 |
GO:000091016 | Esophagus | ESCC | cytokinesis | 115/8552 | 173/18723 | 2.48e-08 | 4.68e-07 | 115 |
GO:00069994 | Esophagus | ESCC | nuclear pore organization | 14/8552 | 14/18723 | 1.71e-05 | 1.52e-04 | 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301321 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0301331 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa03013 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa030131 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa030136 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
hsa0301311 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
hsa030134 | Oral cavity | EOLP | Nucleocytoplasmic transport | 34/1218 | 108/8465 | 4.24e-06 | 2.91e-05 | 1.72e-05 | 34 |
hsa030135 | Oral cavity | EOLP | Nucleocytoplasmic transport | 34/1218 | 108/8465 | 4.24e-06 | 2.91e-05 | 1.72e-05 | 34 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AHCTF1 | SNV | Missense_Mutation | c.4405N>A | p.Gly1469Ser | p.G1469S | Q8WYP5 | protein_coding | tolerated(1) | benign(0) | TCGA-E2-A1IF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
AHCTF1 | SNV | Missense_Mutation | rs756851524 | c.5227N>A | p.Val1743Met | p.V1743M | Q8WYP5 | protein_coding | tolerated(0.54) | benign(0.015) | TCGA-E9-A1R5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
AHCTF1 | SNV | Missense_Mutation | c.6456N>C | p.Leu2152Phe | p.L2152F | Q8WYP5 | protein_coding | deleterious(0.05) | benign(0.106) | TCGA-E9-A1R7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | fareston | SD | |
AHCTF1 | SNV | Missense_Mutation | c.6451N>A | p.Glu2151Lys | p.E2151K | Q8WYP5 | protein_coding | deleterious(0.03) | benign(0.222) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
AHCTF1 | SNV | Missense_Mutation | novel | c.5314N>C | p.Ala1772Pro | p.A1772P | Q8WYP5 | protein_coding | tolerated(0.17) | benign(0.047) | TCGA-OL-A5DA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AHCTF1 | insertion | In_Frame_Ins | novel | c.4926_4927insTATGAATATGAATCCTTA | p.Asp1642_Asn1643insTyrGluTyrGluSerLeu | p.D1642_N1643insYEYESL | Q8WYP5 | protein_coding | TCGA-A8-A091-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | PD | ||
AHCTF1 | deletion | Frame_Shift_Del | novel | c.1650delA | p.Glu551LysfsTer4 | p.E551Kfs*4 | Q8WYP5 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
AHCTF1 | SNV | Missense_Mutation | novel | c.6403C>T | p.Pro2135Ser | p.P2135S | Q8WYP5 | protein_coding | tolerated(0.4) | benign(0.042) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
AHCTF1 | SNV | Missense_Mutation | c.3584C>T | p.Ala1195Val | p.A1195V | Q8WYP5 | protein_coding | tolerated(0.1) | benign(0.106) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
AHCTF1 | SNV | Missense_Mutation | c.4099N>C | p.Asp1367His | p.D1367H | Q8WYP5 | protein_coding | deleterious(0.01) | possibly_damaging(0.771) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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