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Gene: AGO1 |
Gene summary for AGO1 |
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Gene information | Species | Human | Gene symbol | AGO1 | Gene ID | 26523 |
Gene name | argonaute RISC component 1 | |
Gene Alias | EIF2C | |
Cytomap | 1p34.3 | |
Gene Type | protein-coding | GO ID | GO:0000956 | UniProtAcc | B2RAD8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26523 | AGO1 | HCC1_Meng | Human | Liver | HCC | 1.80e-51 | 1.25e-01 | 0.0246 |
26523 | AGO1 | HCC2_Meng | Human | Liver | HCC | 1.91e-11 | 7.94e-02 | 0.0107 |
26523 | AGO1 | HCC1 | Human | Liver | HCC | 3.78e-04 | 3.77e+00 | 0.5336 |
26523 | AGO1 | HCC2 | Human | Liver | HCC | 7.86e-14 | 2.92e+00 | 0.5341 |
26523 | AGO1 | S014 | Human | Liver | HCC | 4.83e-17 | 6.33e-01 | 0.2254 |
26523 | AGO1 | S015 | Human | Liver | HCC | 6.24e-21 | 7.94e-01 | 0.2375 |
26523 | AGO1 | S016 | Human | Liver | HCC | 1.20e-22 | 6.84e-01 | 0.2243 |
26523 | AGO1 | S027 | Human | Liver | HCC | 5.73e-07 | 5.43e-01 | 0.2446 |
26523 | AGO1 | S028 | Human | Liver | HCC | 6.68e-12 | 4.77e-01 | 0.2503 |
26523 | AGO1 | S029 | Human | Liver | HCC | 8.44e-11 | 5.72e-01 | 0.2581 |
26523 | AGO1 | male-WTA | Human | Thyroid | PTC | 8.34e-11 | 1.25e-01 | 0.1037 |
26523 | AGO1 | PTC01 | Human | Thyroid | PTC | 7.47e-03 | 8.52e-02 | 0.1899 |
26523 | AGO1 | PTC04 | Human | Thyroid | PTC | 1.45e-08 | 9.92e-02 | 0.1927 |
26523 | AGO1 | PTC05 | Human | Thyroid | PTC | 9.85e-04 | 3.05e-01 | 0.2065 |
26523 | AGO1 | PTC06 | Human | Thyroid | PTC | 1.62e-13 | 3.44e-01 | 0.2057 |
26523 | AGO1 | PTC07 | Human | Thyroid | PTC | 6.55e-10 | 1.95e-01 | 0.2044 |
26523 | AGO1 | ATC12 | Human | Thyroid | ATC | 1.09e-02 | 1.17e-01 | 0.34 |
26523 | AGO1 | ATC13 | Human | Thyroid | ATC | 1.16e-38 | 6.69e-01 | 0.34 |
26523 | AGO1 | ATC2 | Human | Thyroid | ATC | 4.21e-05 | 4.23e-01 | 0.34 |
26523 | AGO1 | ATC4 | Human | Thyroid | ATC | 2.28e-04 | 1.68e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:004427021 | Liver | HCC | cellular nitrogen compound catabolic process | 303/7958 | 451/18723 | 9.76e-27 | 3.64e-24 | 303 |
GO:004670021 | Liver | HCC | heterocycle catabolic process | 299/7958 | 445/18723 | 2.07e-26 | 7.29e-24 | 299 |
GO:190136121 | Liver | HCC | organic cyclic compound catabolic process | 325/7958 | 495/18723 | 6.52e-26 | 2.18e-23 | 325 |
GO:001943921 | Liver | HCC | aromatic compound catabolic process | 309/7958 | 467/18723 | 1.56e-25 | 4.94e-23 | 309 |
GO:000640121 | Liver | HCC | RNA catabolic process | 201/7958 | 278/18723 | 3.88e-24 | 1.02e-21 | 201 |
GO:003465521 | Liver | HCC | nucleobase-containing compound catabolic process | 273/7958 | 407/18723 | 4.84e-24 | 1.23e-21 | 273 |
GO:000640221 | Liver | HCC | mRNA catabolic process | 169/7958 | 232/18723 | 4.50e-21 | 6.96e-19 | 169 |
GO:007182622 | Liver | HCC | ribonucleoprotein complex subunit organization | 159/7958 | 227/18723 | 3.14e-17 | 3.06e-15 | 159 |
GO:000641722 | Liver | HCC | regulation of translation | 287/7958 | 468/18723 | 8.79e-17 | 8.08e-15 | 287 |
GO:002261822 | Liver | HCC | ribonucleoprotein complex assembly | 153/7958 | 220/18723 | 3.44e-16 | 2.91e-14 | 153 |
GO:000095621 | Liver | HCC | nuclear-transcribed mRNA catabolic process | 84/7958 | 112/18723 | 2.54e-12 | 1.18e-10 | 84 |
GO:003105021 | Liver | HCC | dsRNA processing | 38/7958 | 54/18723 | 3.15e-05 | 3.21e-04 | 38 |
GO:007091821 | Liver | HCC | production of small RNA involved in gene silencing by RNA | 38/7958 | 54/18723 | 3.15e-05 | 3.21e-04 | 38 |
GO:003519621 | Liver | HCC | production of miRNAs involved in gene silencing by miRNA | 36/7958 | 52/18723 | 8.79e-05 | 7.66e-04 | 36 |
GO:00310541 | Liver | HCC | pre-miRNA processing | 13/7958 | 14/18723 | 1.25e-04 | 1.03e-03 | 13 |
GO:003424921 | Liver | HCC | negative regulation of cellular amide metabolic process | 144/7958 | 273/18723 | 3.80e-04 | 2.61e-03 | 144 |
GO:001714821 | Liver | HCC | negative regulation of translation | 129/7958 | 245/18723 | 8.14e-04 | 4.87e-03 | 129 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AGO1 | SNV | Missense_Mutation | c.647A>G | p.Asp216Gly | p.D216G | Q9UL18 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
AGO1 | SNV | Missense_Mutation | novel | c.2555G>A | p.Arg852His | p.R852H | Q9UL18 | protein_coding | tolerated(0.25) | benign(0.003) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
AGO1 | SNV | Missense_Mutation | rs774432228 | c.262N>T | p.Arg88Cys | p.R88C | Q9UL18 | protein_coding | tolerated(0.11) | benign(0) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AGO1 | SNV | Missense_Mutation | rs748561732 | c.416N>A | p.Arg139Gln | p.R139Q | Q9UL18 | protein_coding | tolerated(0.47) | benign(0.001) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AGO1 | SNV | Missense_Mutation | novel | c.2555G>A | p.Arg852His | p.R852H | Q9UL18 | protein_coding | tolerated(0.25) | benign(0.003) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
AGO1 | SNV | Missense_Mutation | rs748561732 | c.416N>A | p.Arg139Gln | p.R139Q | Q9UL18 | protein_coding | tolerated(0.47) | benign(0.001) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
AGO1 | SNV | Missense_Mutation | c.832C>T | p.Arg278Cys | p.R278C | Q9UL18 | protein_coding | deleterious(0) | benign(0.142) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
AGO1 | SNV | Missense_Mutation | c.580C>T | p.Arg194Cys | p.R194C | Q9UL18 | protein_coding | deleterious(0.03) | probably_damaging(0.913) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
AGO1 | SNV | Missense_Mutation | rs371043471 | c.325G>A | p.Glu109Lys | p.E109K | Q9UL18 | protein_coding | tolerated(1) | benign(0.003) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
AGO1 | SNV | Missense_Mutation | c.1780N>A | p.Ala594Thr | p.A594T | Q9UL18 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-DM-A0XF-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | mayo | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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