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Gene: ADH5 |
Gene summary for ADH5 |
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Gene information | Species | Human | Gene symbol | ADH5 | Gene ID | 128 |
Gene name | alcohol dehydrogenase 5 (class III), chi polypeptide | |
Gene Alias | ADH-3 | |
Cytomap | 4q23 | |
Gene Type | protein-coding | GO ID | GO:0001523 | UniProtAcc | P11766 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
128 | ADH5 | HTA11_78_2000001011 | Human | Colorectum | AD | 5.29e-03 | 4.82e-01 | -0.1088 |
128 | ADH5 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.01e-13 | 6.02e-01 | -0.1954 |
128 | ADH5 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.34e-25 | 9.87e-01 | 0.294 |
128 | ADH5 | A015-C-203 | Human | Colorectum | FAP | 8.94e-08 | -1.74e-01 | -0.1294 |
128 | ADH5 | A002-C-201 | Human | Colorectum | FAP | 4.32e-05 | -2.33e-01 | 0.0324 |
128 | ADH5 | A001-C-108 | Human | Colorectum | FAP | 4.38e-08 | -2.65e-01 | -0.0272 |
128 | ADH5 | A002-C-205 | Human | Colorectum | FAP | 5.01e-08 | -2.64e-01 | -0.1236 |
128 | ADH5 | A015-C-005 | Human | Colorectum | FAP | 2.13e-03 | -2.59e-01 | -0.0336 |
128 | ADH5 | A015-C-006 | Human | Colorectum | FAP | 8.41e-05 | -2.71e-01 | -0.0994 |
128 | ADH5 | A015-C-106 | Human | Colorectum | FAP | 6.23e-05 | -2.25e-01 | -0.0511 |
128 | ADH5 | A002-C-114 | Human | Colorectum | FAP | 7.79e-04 | -1.97e-01 | -0.1561 |
128 | ADH5 | A015-C-104 | Human | Colorectum | FAP | 2.36e-10 | -1.91e-01 | -0.1899 |
128 | ADH5 | A001-C-014 | Human | Colorectum | FAP | 5.58e-09 | -2.69e-01 | 0.0135 |
128 | ADH5 | A002-C-016 | Human | Colorectum | FAP | 3.56e-05 | -1.65e-01 | 0.0521 |
128 | ADH5 | A015-C-002 | Human | Colorectum | FAP | 1.28e-04 | -3.05e-01 | -0.0763 |
128 | ADH5 | A001-C-203 | Human | Colorectum | FAP | 1.69e-02 | -1.86e-01 | -0.0481 |
128 | ADH5 | A002-C-116 | Human | Colorectum | FAP | 3.04e-10 | -2.51e-01 | -0.0452 |
128 | ADH5 | A014-C-008 | Human | Colorectum | FAP | 3.87e-03 | -1.77e-01 | -0.191 |
128 | ADH5 | A018-E-020 | Human | Colorectum | FAP | 1.93e-05 | -2.13e-01 | -0.2034 |
128 | ADH5 | F034 | Human | Colorectum | FAP | 1.07e-08 | -2.66e-01 | -0.0665 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006091 | Colorectum | AD | generation of precursor metabolites and energy | 209/3918 | 490/18723 | 3.17e-28 | 6.61e-25 | 209 |
GO:0022900 | Colorectum | AD | electron transport chain | 89/3918 | 175/18723 | 1.42e-18 | 8.91e-16 | 89 |
GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
GO:0009636 | Colorectum | AD | response to toxic substance | 88/3918 | 262/18723 | 1.12e-06 | 3.72e-05 | 88 |
GO:0019395 | Colorectum | AD | fatty acid oxidation | 40/3918 | 103/18723 | 2.43e-05 | 4.69e-04 | 40 |
GO:0006066 | Colorectum | AD | alcohol metabolic process | 106/3918 | 353/18723 | 3.02e-05 | 5.57e-04 | 106 |
GO:0098754 | Colorectum | AD | detoxification | 53/3918 | 152/18723 | 4.63e-05 | 7.98e-04 | 53 |
GO:0006631 | Colorectum | AD | fatty acid metabolic process | 114/3918 | 390/18723 | 5.58e-05 | 9.44e-04 | 114 |
GO:0034440 | Colorectum | AD | lipid oxidation | 40/3918 | 108/18723 | 8.52e-05 | 1.32e-03 | 40 |
GO:0097237 | Colorectum | AD | cellular response to toxic substance | 44/3918 | 124/18723 | 1.24e-04 | 1.80e-03 | 44 |
GO:0030258 | Colorectum | AD | lipid modification | 67/3918 | 212/18723 | 1.66e-04 | 2.27e-03 | 67 |
GO:1990748 | Colorectum | AD | cellular detoxification | 41/3918 | 116/18723 | 2.29e-04 | 2.97e-03 | 41 |
GO:0034308 | Colorectum | AD | primary alcohol metabolic process | 35/3918 | 102/18723 | 1.16e-03 | 1.05e-02 | 35 |
GO:0006067 | Colorectum | AD | ethanol metabolic process | 11/3918 | 21/18723 | 1.43e-03 | 1.22e-02 | 11 |
GO:0006081 | Colorectum | AD | cellular aldehyde metabolic process | 22/3918 | 60/18723 | 3.64e-03 | 2.60e-02 | 22 |
GO:00060912 | Colorectum | MSS | generation of precursor metabolites and energy | 186/3467 | 490/18723 | 1.14e-24 | 2.15e-21 | 186 |
GO:00229002 | Colorectum | MSS | electron transport chain | 83/3467 | 175/18723 | 2.06e-18 | 1.17e-15 | 83 |
GO:00096362 | Colorectum | MSS | response to toxic substance | 73/3467 | 262/18723 | 1.26e-04 | 1.94e-03 | 73 |
GO:00060662 | Colorectum | MSS | alcohol metabolic process | 92/3467 | 353/18723 | 2.57e-04 | 3.46e-03 | 92 |
GO:00442822 | Colorectum | MSS | small molecule catabolic process | 94/3467 | 376/18723 | 9.85e-04 | 9.86e-03 | 94 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa01200 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa00620 | Colorectum | AD | Pyruvate metabolism | 28/2092 | 47/8465 | 3.71e-07 | 5.41e-06 | 3.45e-06 | 28 |
hsa00010 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
hsa00071 | Colorectum | AD | Fatty acid degradation | 20/2092 | 43/8465 | 1.50e-03 | 8.69e-03 | 5.54e-03 | 20 |
hsa012001 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa006201 | Colorectum | AD | Pyruvate metabolism | 28/2092 | 47/8465 | 3.71e-07 | 5.41e-06 | 3.45e-06 | 28 |
hsa000101 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
hsa000711 | Colorectum | AD | Fatty acid degradation | 20/2092 | 43/8465 | 1.50e-03 | 8.69e-03 | 5.54e-03 | 20 |
hsa006204 | Colorectum | MSS | Pyruvate metabolism | 24/1875 | 47/8465 | 1.25e-05 | 1.35e-04 | 8.27e-05 | 24 |
hsa012004 | Colorectum | MSS | Carbon metabolism | 43/1875 | 115/8465 | 1.37e-04 | 1.17e-03 | 7.19e-04 | 43 |
hsa000104 | Colorectum | MSS | Glycolysis / Gluconeogenesis | 28/1875 | 67/8465 | 2.36e-04 | 1.81e-03 | 1.11e-03 | 28 |
hsa000714 | Colorectum | MSS | Fatty acid degradation | 17/1875 | 43/8465 | 7.50e-03 | 2.86e-02 | 1.75e-02 | 17 |
hsa006205 | Colorectum | MSS | Pyruvate metabolism | 24/1875 | 47/8465 | 1.25e-05 | 1.35e-04 | 8.27e-05 | 24 |
hsa012005 | Colorectum | MSS | Carbon metabolism | 43/1875 | 115/8465 | 1.37e-04 | 1.17e-03 | 7.19e-04 | 43 |
hsa000105 | Colorectum | MSS | Glycolysis / Gluconeogenesis | 28/1875 | 67/8465 | 2.36e-04 | 1.81e-03 | 1.11e-03 | 28 |
hsa000715 | Colorectum | MSS | Fatty acid degradation | 17/1875 | 43/8465 | 7.50e-03 | 2.86e-02 | 1.75e-02 | 17 |
hsa012006 | Colorectum | FAP | Carbon metabolism | 38/1404 | 115/8465 | 1.04e-05 | 1.44e-04 | 8.76e-05 | 38 |
hsa000106 | Colorectum | FAP | Glycolysis / Gluconeogenesis | 24/1404 | 67/8465 | 1.05e-04 | 9.46e-04 | 5.76e-04 | 24 |
hsa006206 | Colorectum | FAP | Pyruvate metabolism | 17/1404 | 47/8465 | 9.18e-04 | 5.20e-03 | 3.16e-03 | 17 |
hsa000716 | Colorectum | FAP | Fatty acid degradation | 15/1404 | 43/8465 | 2.73e-03 | 1.23e-02 | 7.50e-03 | 15 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADH5 | SNV | Missense_Mutation | novel | c.58N>T | p.Leu20Phe | p.L20F | P11766 | protein_coding | tolerated(0.11) | benign(0.226) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ADH5 | SNV | Missense_Mutation | novel | c.214N>C | p.Ile72Leu | p.I72L | P11766 | protein_coding | deleterious(0.01) | benign(0.029) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ADH5 | insertion | Frame_Shift_Ins | novel | c.236_237insG | p.Val80SerfsTer3 | p.V80Sfs*3 | P11766 | protein_coding | TCGA-K7-A5RG-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
ADH5 | SNV | Missense_Mutation | novel | c.259N>T | p.Asp87Tyr | p.D87Y | P11766 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-95-7043-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ADH5 | SNV | Missense_Mutation | c.1119G>C | p.Lys373Asn | p.K373N | P11766 | protein_coding | tolerated(0.47) | benign(0.001) | TCGA-39-5028-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ADH5 | SNV | Missense_Mutation | novel | c.423N>T | p.Met141Ile | p.M141I | P11766 | protein_coding | tolerated(0.06) | benign(0.154) | TCGA-85-6798-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | PD |
ADH5 | SNV | Missense_Mutation | novel | c.70N>A | p.Glu24Lys | p.E24K | P11766 | protein_coding | deleterious(0.02) | benign(0.007) | TCGA-CN-4723-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ADH5 | SNV | Missense_Mutation | c.200N>G | p.His67Arg | p.H67R | P11766 | protein_coding | deleterious(0) | probably_damaging(0.945) | TCGA-CN-4728-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | vectibix | SD | |
ADH5 | SNV | Missense_Mutation | novel | c.166N>A | p.Asp56Asn | p.D56N | P11766 | protein_coding | tolerated(0.06) | benign(0.324) | TCGA-P3-A6T2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
ADH5 | SNV | Missense_Mutation | c.905N>T | p.Ala302Val | p.A302V | P11766 | protein_coding | deleterious(0.01) | benign(0.225) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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