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Gene: ADGRE3 |
Gene summary for ADGRE3 |
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Gene information | Species | Human | Gene symbol | ADGRE3 | Gene ID | 84658 |
Gene name | adhesion G protein-coupled receptor E3 | |
Gene Alias | EMR3 | |
Cytomap | 19p13.12 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | A1L1B9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84658 | ADGRE3 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.77e-13 | 5.82e-01 | -0.1088 |
84658 | ADGRE3 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.51e-17 | 5.80e-01 | -0.1954 |
84658 | ADGRE3 | HTA11_411_2000001011 | Human | Colorectum | SER | 7.05e-03 | 5.59e-01 | -0.2602 |
84658 | ADGRE3 | HTA11_5212_2000001011 | Human | Colorectum | AD | 7.94e-03 | 5.26e-01 | -0.2061 |
84658 | ADGRE3 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.84e-02 | 2.46e-01 | 0.096 |
84658 | ADGRE3 | HTA11_6801_2000001011 | Human | Colorectum | SER | 4.92e-05 | 6.04e-01 | 0.0171 |
84658 | ADGRE3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.93e-05 | 1.96e-01 | 0.0674 |
84658 | ADGRE3 | HTA11_7469_2000001011 | Human | Colorectum | AD | 1.06e-02 | 5.61e-01 | -0.0124 |
84658 | ADGRE3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.26e-28 | 7.14e-01 | 0.294 |
84658 | ADGRE3 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 5.79e-12 | 5.31e-01 | 0.281 |
84658 | ADGRE3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.99e-11 | 3.91e-01 | 0.3859 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADGRE3 | SNV | Missense_Mutation | novel | c.1252C>A | p.Leu418Met | p.L418M | Q9BY15 | protein_coding | deleterious(0) | probably_damaging(0.949) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ADGRE3 | SNV | Missense_Mutation | novel | c.751G>A | p.Ala251Thr | p.A251T | Q9BY15 | protein_coding | deleterious(0.02) | benign(0.028) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ADGRE3 | SNV | Missense_Mutation | novel | c.190A>G | p.Thr64Ala | p.T64A | Q9BY15 | protein_coding | tolerated(0.36) | benign(0.027) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ADGRE3 | SNV | Missense_Mutation | novel | c.569N>G | p.Asp190Gly | p.D190G | Q9BY15 | protein_coding | tolerated(0.54) | benign(0) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ADGRE3 | SNV | Missense_Mutation | novel | c.1664N>T | p.Thr555Ile | p.T555I | Q9BY15 | protein_coding | tolerated(0.56) | benign(0.028) | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ADGRE3 | SNV | Missense_Mutation | novel | c.1387A>G | p.Met463Val | p.M463V | Q9BY15 | protein_coding | deleterious(0.04) | benign(0.326) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
ADGRE3 | SNV | Missense_Mutation | c.1697N>A | p.Cys566Tyr | p.C566Y | Q9BY15 | protein_coding | deleterious(0) | possibly_damaging(0.702) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ADGRE3 | SNV | Missense_Mutation | novel | c.1862N>T | p.Ser621Phe | p.S621F | Q9BY15 | protein_coding | deleterious(0.05) | possibly_damaging(0.764) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ADGRE3 | SNV | Missense_Mutation | c.1274N>T | p.Ala425Val | p.A425V | Q9BY15 | protein_coding | tolerated(0.21) | benign(0.241) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ADGRE3 | SNV | Missense_Mutation | c.1558N>G | p.Leu520Val | p.L520V | Q9BY15 | protein_coding | deleterious(0) | possibly_damaging(0.728) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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