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Gene: ACTRT3 |
Gene summary for ACTRT3 |
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Gene information | Species | Human | Gene symbol | ACTRT3 | Gene ID | 84517 |
Gene name | actin related protein T3 | |
Gene Alias | ARP-T3 | |
Cytomap | 3q26.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9BYD9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84517 | ACTRT3 | P2T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.14e-01 | 0.1177 |
84517 | ACTRT3 | P4T-E | Human | Esophagus | ESCC | 8.33e-13 | 3.48e-01 | 0.1323 |
84517 | ACTRT3 | P5T-E | Human | Esophagus | ESCC | 2.03e-09 | 3.64e-01 | 0.1327 |
84517 | ACTRT3 | P11T-E | Human | Esophagus | ESCC | 3.25e-05 | 2.91e-01 | 0.1426 |
84517 | ACTRT3 | P16T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.85e-01 | 0.1153 |
84517 | ACTRT3 | P22T-E | Human | Esophagus | ESCC | 1.88e-04 | 2.22e-01 | 0.1236 |
84517 | ACTRT3 | P36T-E | Human | Esophagus | ESCC | 2.09e-07 | 3.34e-01 | 0.1187 |
84517 | ACTRT3 | P42T-E | Human | Esophagus | ESCC | 3.05e-02 | 1.05e-01 | 0.1175 |
84517 | ACTRT3 | P47T-E | Human | Esophagus | ESCC | 2.05e-07 | 2.45e-01 | 0.1067 |
84517 | ACTRT3 | P49T-E | Human | Esophagus | ESCC | 6.53e-04 | 6.20e-01 | 0.1768 |
84517 | ACTRT3 | P52T-E | Human | Esophagus | ESCC | 1.97e-10 | 4.27e-01 | 0.1555 |
84517 | ACTRT3 | P74T-E | Human | Esophagus | ESCC | 8.28e-10 | 4.96e-01 | 0.1479 |
84517 | ACTRT3 | P79T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.14e-01 | 0.1154 |
84517 | ACTRT3 | P83T-E | Human | Esophagus | ESCC | 3.53e-13 | 3.98e-01 | 0.1738 |
84517 | ACTRT3 | P89T-E | Human | Esophagus | ESCC | 3.85e-03 | 2.94e-01 | 0.1752 |
84517 | ACTRT3 | P91T-E | Human | Esophagus | ESCC | 2.11e-02 | 3.18e-01 | 0.1828 |
84517 | ACTRT3 | P107T-E | Human | Esophagus | ESCC | 2.08e-04 | 1.36e-01 | 0.171 |
84517 | ACTRT3 | P128T-E | Human | Esophagus | ESCC | 7.29e-13 | 5.29e-01 | 0.1241 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACTRT3 | SNV | Missense_Mutation | c.351G>T | p.Gln117His | p.Q117H | Q9BYD9 | protein_coding | deleterious(0.01) | benign(0.007) | TCGA-55-6969-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ACTRT3 | SNV | Missense_Mutation | c.195N>A | p.Phe65Leu | p.F65L | Q9BYD9 | protein_coding | tolerated(0.08) | benign(0.007) | TCGA-33-6737-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | gemcitabine | PD | |
ACTRT3 | SNV | Missense_Mutation | c.853N>T | p.Gly285Cys | p.G285C | Q9BYD9 | protein_coding | deleterious(0) | possibly_damaging(0.75) | TCGA-NC-A5HF-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
ACTRT3 | insertion | In_Frame_Ins | novel | c.877_878insTCCACACTG | p.Asn293delinsIleHisThrAsp | p.N293delinsIHTD | Q9BYD9 | protein_coding | TCGA-H7-8502-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | SD | ||
ACTRT3 | SNV | Missense_Mutation | c.853G>T | p.Gly285Cys | p.G285C | Q9BYD9 | protein_coding | deleterious(0) | possibly_damaging(0.75) | TCGA-BR-8081-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ACTRT3 | SNV | Missense_Mutation | c.214N>T | p.Arg72Cys | p.R72C | Q9BYD9 | protein_coding | deleterious(0) | benign(0.029) | TCGA-BR-8363-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ACTRT3 | SNV | Missense_Mutation | c.1090C>A | p.Pro364Thr | p.P364T | Q9BYD9 | protein_coding | tolerated(0.07) | possibly_damaging(0.665) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
ACTRT3 | SNV | Missense_Mutation | novel | c.31N>A | p.Asp11Asn | p.D11N | Q9BYD9 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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