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Gene: ACOT8 |
Gene summary for ACOT8 |
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Gene information | Species | Human | Gene symbol | ACOT8 | Gene ID | 10005 |
Gene name | acyl-CoA thioesterase 8 | |
Gene Alias | HNAACTE | |
Cytomap | 20q13.12 | |
Gene Type | protein-coding | GO ID | GO:0001676 | UniProtAcc | O14734 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10005 | ACOT8 | LZE4T | Human | Esophagus | ESCC | 1.10e-04 | 2.61e-01 | 0.0811 |
10005 | ACOT8 | LZE7T | Human | Esophagus | ESCC | 8.78e-04 | 3.93e-01 | 0.0667 |
10005 | ACOT8 | LZE20T | Human | Esophagus | ESCC | 5.52e-06 | 3.80e-01 | 0.0662 |
10005 | ACOT8 | LZE24T | Human | Esophagus | ESCC | 6.28e-16 | 4.69e-01 | 0.0596 |
10005 | ACOT8 | LZE6T | Human | Esophagus | ESCC | 9.29e-05 | 2.88e-01 | 0.0845 |
10005 | ACOT8 | P1T-E | Human | Esophagus | ESCC | 4.61e-02 | 3.27e-01 | 0.0875 |
10005 | ACOT8 | P2T-E | Human | Esophagus | ESCC | 9.67e-18 | 2.82e-01 | 0.1177 |
10005 | ACOT8 | P4T-E | Human | Esophagus | ESCC | 5.81e-23 | 6.53e-01 | 0.1323 |
10005 | ACOT8 | P5T-E | Human | Esophagus | ESCC | 4.29e-11 | 2.35e-01 | 0.1327 |
10005 | ACOT8 | P8T-E | Human | Esophagus | ESCC | 2.39e-24 | 3.68e-01 | 0.0889 |
10005 | ACOT8 | P9T-E | Human | Esophagus | ESCC | 1.35e-04 | 1.77e-01 | 0.1131 |
10005 | ACOT8 | P10T-E | Human | Esophagus | ESCC | 6.76e-36 | 5.65e-01 | 0.116 |
10005 | ACOT8 | P11T-E | Human | Esophagus | ESCC | 1.54e-10 | 4.15e-01 | 0.1426 |
10005 | ACOT8 | P12T-E | Human | Esophagus | ESCC | 1.02e-31 | 4.29e-01 | 0.1122 |
10005 | ACOT8 | P15T-E | Human | Esophagus | ESCC | 1.37e-11 | 3.28e-01 | 0.1149 |
10005 | ACOT8 | P16T-E | Human | Esophagus | ESCC | 2.45e-28 | 4.37e-01 | 0.1153 |
10005 | ACOT8 | P17T-E | Human | Esophagus | ESCC | 4.13e-06 | 3.77e-01 | 0.1278 |
10005 | ACOT8 | P19T-E | Human | Esophagus | ESCC | 6.74e-09 | 5.60e-01 | 0.1662 |
10005 | ACOT8 | P20T-E | Human | Esophagus | ESCC | 1.04e-25 | 6.06e-01 | 0.1124 |
10005 | ACOT8 | P21T-E | Human | Esophagus | ESCC | 2.40e-66 | 1.13e+00 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:0006753110 | Esophagus | ESCC | nucleoside phosphate metabolic process | 288/8552 | 497/18723 | 1.80e-08 | 3.50e-07 | 288 |
GO:0019693111 | Esophagus | ESCC | ribose phosphate metabolic process | 234/8552 | 396/18723 | 4.24e-08 | 7.76e-07 | 234 |
GO:0009117111 | Esophagus | ESCC | nucleotide metabolic process | 282/8552 | 489/18723 | 4.70e-08 | 8.50e-07 | 282 |
GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:0009259111 | Esophagus | ESCC | ribonucleotide metabolic process | 224/8552 | 385/18723 | 4.41e-07 | 6.00e-06 | 224 |
GO:0072521111 | Esophagus | ESCC | purine-containing compound metabolic process | 238/8552 | 416/18723 | 1.20e-06 | 1.49e-05 | 238 |
GO:0009150111 | Esophagus | ESCC | purine ribonucleotide metabolic process | 213/8552 | 368/18723 | 1.40e-06 | 1.69e-05 | 213 |
GO:0006163111 | Esophagus | ESCC | purine nucleotide metabolic process | 226/8552 | 396/18723 | 2.81e-06 | 3.21e-05 | 226 |
GO:00193958 | Esophagus | ESCC | fatty acid oxidation | 69/8552 | 103/18723 | 9.95e-06 | 9.44e-05 | 69 |
GO:00344407 | Esophagus | ESCC | lipid oxidation | 71/8552 | 108/18723 | 2.00e-05 | 1.74e-04 | 71 |
GO:00091012 | Esophagus | ESCC | glycoprotein biosynthetic process | 181/8552 | 317/18723 | 2.54e-05 | 2.15e-04 | 181 |
GO:00090628 | Esophagus | ESCC | fatty acid catabolic process | 66/8552 | 100/18723 | 3.21e-05 | 2.66e-04 | 66 |
GO:00066318 | Esophagus | ESCC | fatty acid metabolic process | 217/8552 | 390/18723 | 4.21e-05 | 3.39e-04 | 217 |
GO:00066358 | Esophagus | ESCC | fatty acid beta-oxidation | 50/8552 | 74/18723 | 1.16e-04 | 8.04e-04 | 50 |
GO:00463948 | Esophagus | ESCC | carboxylic acid biosynthetic process | 175/8552 | 314/18723 | 1.98e-04 | 1.26e-03 | 175 |
GO:00160538 | Esophagus | ESCC | organic acid biosynthetic process | 175/8552 | 316/18723 | 3.04e-04 | 1.82e-03 | 175 |
GO:00723297 | Esophagus | ESCC | monocarboxylic acid catabolic process | 74/8552 | 122/18723 | 6.03e-04 | 3.27e-03 | 74 |
GO:00338655 | Esophagus | ESCC | nucleoside bisphosphate metabolic process | 77/8552 | 128/18723 | 6.71e-04 | 3.55e-03 | 77 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa041467 | Esophagus | ESCC | Peroxisome | 55/4205 | 82/8465 | 1.04e-03 | 3.27e-03 | 1.68e-03 | 55 |
hsa0414612 | Esophagus | ESCC | Peroxisome | 55/4205 | 82/8465 | 1.04e-03 | 3.27e-03 | 1.68e-03 | 55 |
hsa041464 | Liver | HCC | Peroxisome | 58/4020 | 82/8465 | 1.57e-05 | 1.05e-04 | 5.85e-05 | 58 |
hsa001202 | Liver | HCC | Primary bile acid biosynthesis | 14/4020 | 17/8465 | 3.49e-03 | 1.12e-02 | 6.22e-03 | 14 |
hsa041465 | Liver | HCC | Peroxisome | 58/4020 | 82/8465 | 1.57e-05 | 1.05e-04 | 5.85e-05 | 58 |
hsa001203 | Liver | HCC | Primary bile acid biosynthesis | 14/4020 | 17/8465 | 3.49e-03 | 1.12e-02 | 6.22e-03 | 14 |
hsa041466 | Oral cavity | OSCC | Peroxisome | 47/3704 | 82/8465 | 9.01e-03 | 2.01e-02 | 1.03e-02 | 47 |
hsa0414611 | Oral cavity | OSCC | Peroxisome | 47/3704 | 82/8465 | 9.01e-03 | 2.01e-02 | 1.03e-02 | 47 |
hsa0414621 | Oral cavity | LP | Peroxisome | 33/2418 | 82/8465 | 1.48e-02 | 4.69e-02 | 3.03e-02 | 33 |
hsa0414631 | Oral cavity | LP | Peroxisome | 33/2418 | 82/8465 | 1.48e-02 | 4.69e-02 | 3.03e-02 | 33 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACOT8 | SNV | Missense_Mutation | novel | c.778N>C | p.Trp260Arg | p.W260R | O14734 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-34-2605-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | PD |
ACOT8 | SNV | Missense_Mutation | rs750307207 | c.682G>A | p.Ala228Thr | p.A228T | O14734 | protein_coding | deleterious(0.02) | probably_damaging(0.987) | TCGA-34-7107-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ACOT8 | SNV | Missense_Mutation | c.190N>G | p.Leu64Val | p.L64V | O14734 | protein_coding | deleterious(0.02) | possibly_damaging(0.71) | TCGA-46-3769-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | SD | |
ACOT8 | SNV | Missense_Mutation | c.172N>G | p.Gln58Glu | p.Q58E | O14734 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-51-4079-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ACOT8 | SNV | Missense_Mutation | novel | c.556N>A | p.Glu186Lys | p.E186K | O14734 | protein_coding | deleterious(0) | possibly_damaging(0.864) | TCGA-CQ-7063-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ACOT8 | SNV | Missense_Mutation | novel | c.663N>C | p.Lys221Asn | p.K221N | O14734 | protein_coding | tolerated(0.08) | benign(0.153) | TCGA-CV-A6K1-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ACOT8 | SNV | Missense_Mutation | novel | c.507N>C | p.Lys169Asn | p.K169N | O14734 | protein_coding | deleterious(0.02) | benign(0.082) | TCGA-TN-A7HJ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
ACOT8 | SNV | Missense_Mutation | rs749132839 | c.826N>A | p.Glu276Lys | p.E276K | O14734 | protein_coding | deleterious(0.01) | probably_damaging(0.974) | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD |
ACOT8 | SNV | Missense_Mutation | rs746146702 | c.818A>G | p.Tyr273Cys | p.Y273C | O14734 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-HU-A4H8-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | didox | PD |
ACOT8 | deletion | Frame_Shift_Del | novel | c.583delC | p.Leu195Ter | p.L195* | O14734 | protein_coding | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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