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Gene: ABCC3 |
Gene summary for ABCC3 |
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Gene information | Species | Human | Gene symbol | ABCC3 | Gene ID | 8714 |
Gene name | ATP binding cassette subfamily C member 3 | |
Gene Alias | ABC31 | |
Cytomap | 17q21.33 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | O15438 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8714 | ABCC3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.25e-19 | 1.36e+00 | -0.1808 |
8714 | ABCC3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.39e-41 | 1.55e+00 | -0.0811 |
8714 | ABCC3 | HTA11_78_2000001011 | Human | Colorectum | AD | 5.63e-17 | 9.98e-01 | -0.1088 |
8714 | ABCC3 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.32e-53 | 1.58e+00 | -0.1954 |
8714 | ABCC3 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.88e-11 | 1.35e+00 | -0.2602 |
8714 | ABCC3 | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.17e-11 | 9.93e-01 | -0.2196 |
8714 | ABCC3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.24e-16 | 9.02e-01 | -0.1207 |
8714 | ABCC3 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.90e-38 | 1.52e+00 | -0.1526 |
8714 | ABCC3 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.95e-16 | 1.15e+00 | -0.1464 |
8714 | ABCC3 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.47e-27 | 1.15e+00 | -0.1001 |
8714 | ABCC3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.48e-15 | 1.44e+00 | -0.059 |
8714 | ABCC3 | HTA11_2992_2000001011 | Human | Colorectum | SER | 6.35e-15 | 9.63e-01 | -0.1706 |
8714 | ABCC3 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.51e-02 | 3.74e-01 | -0.2061 |
8714 | ABCC3 | HTA11_5216_2000001011 | Human | Colorectum | SER | 4.77e-05 | 6.33e-01 | -0.1462 |
8714 | ABCC3 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.17e-10 | 9.17e-01 | -0.0842 |
8714 | ABCC3 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.31e-03 | 5.01e-01 | 0.0446 |
8714 | ABCC3 | HTA11_8622_2000001021 | Human | Colorectum | SER | 7.48e-05 | 6.17e-01 | 0.0528 |
8714 | ABCC3 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.00e-08 | 8.12e-01 | -0.0177 |
8714 | ABCC3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 8.85e-03 | 4.75e-01 | 0.0338 |
8714 | ABCC3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.33e-02 | 4.05e-01 | 0.0674 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:0015698 | Colorectum | AD | inorganic anion transport | 52/3918 | 180/18723 | 6.83e-03 | 4.22e-02 | 52 |
GO:0150104 | Colorectum | MSS | transport across blood-brain barrier | 28/3467 | 87/18723 | 1.54e-03 | 1.41e-02 | 28 |
GO:0010232 | Colorectum | MSS | vascular transport | 28/3467 | 88/18723 | 1.87e-03 | 1.64e-02 | 28 |
GO:00108761 | Colorectum | MSS | lipid localization | 104/3467 | 448/18723 | 6.76e-03 | 4.38e-02 | 104 |
GO:01501041 | Colorectum | FAP | transport across blood-brain barrier | 25/2622 | 87/18723 | 2.63e-04 | 3.59e-03 | 25 |
GO:00068691 | Colorectum | FAP | lipid transport | 81/2622 | 398/18723 | 2.84e-04 | 3.76e-03 | 81 |
GO:00102321 | Colorectum | FAP | vascular transport | 25/2622 | 88/18723 | 3.19e-04 | 4.12e-03 | 25 |
GO:0003018 | Colorectum | FAP | vascular process in circulatory system | 56/2622 | 263/18723 | 7.67e-04 | 8.12e-03 | 56 |
GO:00108762 | Colorectum | FAP | lipid localization | 85/2622 | 448/18723 | 1.92e-03 | 1.63e-02 | 85 |
GO:00156981 | Colorectum | FAP | inorganic anion transport | 38/2622 | 180/18723 | 5.73e-03 | 3.67e-02 | 38 |
GO:00030181 | Colorectum | CRC | vascular process in circulatory system | 45/2078 | 263/18723 | 2.10e-03 | 2.08e-02 | 45 |
GO:00068692 | Colorectum | CRC | lipid transport | 63/2078 | 398/18723 | 2.36e-03 | 2.26e-02 | 63 |
GO:00108763 | Colorectum | CRC | lipid localization | 68/2078 | 448/18723 | 4.60e-03 | 3.58e-02 | 68 |
GO:01501042 | Colorectum | CRC | transport across blood-brain barrier | 18/2078 | 87/18723 | 6.50e-03 | 4.69e-02 | 18 |
GO:00108765 | Liver | NAFLD | lipid localization | 79/1882 | 448/18723 | 4.75e-07 | 2.92e-05 | 79 |
GO:00068694 | Liver | NAFLD | lipid transport | 71/1882 | 398/18723 | 1.16e-06 | 5.59e-05 | 71 |
GO:0015850 | Liver | NAFLD | organic hydroxy compound transport | 50/1882 | 284/18723 | 6.01e-05 | 1.32e-03 | 50 |
GO:00030182 | Liver | NAFLD | vascular process in circulatory system | 46/1882 | 263/18723 | 1.36e-04 | 2.58e-03 | 46 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04976 | Colorectum | FAP | Bile secretion | 24/1404 | 89/8465 | 8.76e-03 | 3.21e-02 | 1.96e-02 | 24 |
hsa049761 | Colorectum | FAP | Bile secretion | 24/1404 | 89/8465 | 8.76e-03 | 3.21e-02 | 1.96e-02 | 24 |
hsa015232 | Esophagus | ESCC | Antifolate resistance | 22/4205 | 30/8465 | 7.23e-03 | 1.76e-02 | 8.99e-03 | 22 |
hsa0152311 | Esophagus | ESCC | Antifolate resistance | 22/4205 | 30/8465 | 7.23e-03 | 1.76e-02 | 8.99e-03 | 22 |
hsa02010 | Liver | NAFLD | ABC transporters | 16/1043 | 45/8465 | 4.97e-05 | 1.16e-03 | 9.37e-04 | 16 |
hsa049762 | Liver | NAFLD | Bile secretion | 20/1043 | 89/8465 | 5.08e-03 | 4.43e-02 | 3.57e-02 | 20 |
hsa020101 | Liver | NAFLD | ABC transporters | 16/1043 | 45/8465 | 4.97e-05 | 1.16e-03 | 9.37e-04 | 16 |
hsa0497611 | Liver | NAFLD | Bile secretion | 20/1043 | 89/8465 | 5.08e-03 | 4.43e-02 | 3.57e-02 | 20 |
hsa01523 | Liver | HCC | Antifolate resistance | 21/4020 | 30/8465 | 1.06e-02 | 2.71e-02 | 1.51e-02 | 21 |
hsa020102 | Liver | HCC | ABC transporters | 29/4020 | 45/8465 | 1.62e-02 | 3.88e-02 | 2.16e-02 | 29 |
hsa015231 | Liver | HCC | Antifolate resistance | 21/4020 | 30/8465 | 1.06e-02 | 2.71e-02 | 1.51e-02 | 21 |
hsa020103 | Liver | HCC | ABC transporters | 29/4020 | 45/8465 | 1.62e-02 | 3.88e-02 | 2.16e-02 | 29 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ABCC3 | SNV | Missense_Mutation | c.2200N>A | p.Glu734Lys | p.E734K | O15438 | protein_coding | tolerated(0.13) | benign(0.015) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ABCC3 | SNV | Missense_Mutation | novel | c.1921N>A | p.Pro641Thr | p.P641T | O15438 | protein_coding | tolerated(0.09) | benign(0.312) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ABCC3 | SNV | Missense_Mutation | rs577213087 | c.1459N>T | p.Arg487Cys | p.R487C | O15438 | protein_coding | deleterious(0.01) | probably_damaging(0.976) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ABCC3 | SNV | Missense_Mutation | novel | c.1066N>G | p.Met356Val | p.M356V | O15438 | protein_coding | deleterious(0) | probably_damaging(0.936) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ABCC3 | SNV | Missense_Mutation | rs762463467 | c.1091N>T | p.Ser364Leu | p.S364L | O15438 | protein_coding | deleterious(0) | benign(0.207) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ABCC3 | SNV | Missense_Mutation | c.352N>A | p.Leu118Met | p.L118M | O15438 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ABCC3 | SNV | Missense_Mutation | c.1973N>A | p.Ala658Asp | p.A658D | O15438 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
ABCC3 | SNV | Missense_Mutation | rs543738423 | c.1423G>A | p.Ala475Thr | p.A475T | O15438 | protein_coding | tolerated(1) | benign(0.025) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ABCC3 | SNV | Missense_Mutation | c.3884N>T | p.Ser1295Phe | p.S1295F | O15438 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ABCC3 | SNV | Missense_Mutation | novel | c.265N>G | p.Phe89Val | p.F89V | O15438 | protein_coding | tolerated(0.12) | benign(0.254) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8714 | ABCC3 | DRUG RESISTANCE, DRUGGABLE GENOME, TRANSPORTER, ABC TRANSPORTER, CLINICALLY ACTIONABLE | EMTRICITABINE | EMTRICITABINE | 17172311 | |
8714 | ABCC3 | DRUG RESISTANCE, DRUGGABLE GENOME, TRANSPORTER, ABC TRANSPORTER, CLINICALLY ACTIONABLE | MONOMETHYL AURISTATIN E | 18593940 | ||
8714 | ABCC3 | DRUG RESISTANCE, DRUGGABLE GENOME, TRANSPORTER, ABC TRANSPORTER, CLINICALLY ACTIONABLE | methotrexate | METHOTREXATE | 22016816,21317831,21606946 | |
8714 | ABCC3 | DRUG RESISTANCE, DRUGGABLE GENOME, TRANSPORTER, ABC TRANSPORTER, CLINICALLY ACTIONABLE | CEFOPERAZONE | CEFOPERAZONE | 22166395 | |
8714 | ABCC3 | DRUG RESISTANCE, DRUGGABLE GENOME, TRANSPORTER, ABC TRANSPORTER, CLINICALLY ACTIONABLE | DOXORUBICIN | DOXORUBICIN | ||
8714 | ABCC3 | DRUG RESISTANCE, DRUGGABLE GENOME, TRANSPORTER, ABC TRANSPORTER, CLINICALLY ACTIONABLE | ABACAVIR | ABACAVIR | 17172311 | |
8714 | ABCC3 | DRUG RESISTANCE, DRUGGABLE GENOME, TRANSPORTER, ABC TRANSPORTER, CLINICALLY ACTIONABLE | CEFACLOR | CEFACLOR | 22166395 | |
8714 | ABCC3 | DRUG RESISTANCE, DRUGGABLE GENOME, TRANSPORTER, ABC TRANSPORTER, CLINICALLY ACTIONABLE | TENOFOVIR | TENOFOVIR | 17172311 | |
8714 | ABCC3 | DRUG RESISTANCE, DRUGGABLE GENOME, TRANSPORTER, ABC TRANSPORTER, CLINICALLY ACTIONABLE | DELAVIRDINE | DELAVIRDINE | 17172311 | |
8714 | ABCC3 | DRUG RESISTANCE, DRUGGABLE GENOME, TRANSPORTER, ABC TRANSPORTER, CLINICALLY ACTIONABLE | cisplatin | CISPLATIN | 25141953,22016816,31666714,27457817 |
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