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Gene: MED12 |
Gene summary for MED12 |
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Gene information | Species | Human | Gene symbol | MED12 | Gene ID | 9968 |
Gene name | mediator complex subunit 12 | |
Gene Alias | ARC240 | |
Cytomap | Xq13.1 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q93074 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9968 | MED12 | LZE7T | Human | Esophagus | ESCC | 9.32e-08 | 4.72e-01 | 0.0667 |
9968 | MED12 | LZE8T | Human | Esophagus | ESCC | 2.72e-03 | 1.10e-01 | 0.067 |
9968 | MED12 | LZE24T | Human | Esophagus | ESCC | 8.28e-18 | 3.57e-01 | 0.0596 |
9968 | MED12 | LZE21T | Human | Esophagus | ESCC | 8.02e-04 | 2.19e-01 | 0.0655 |
9968 | MED12 | P1T-E | Human | Esophagus | ESCC | 5.20e-08 | 2.96e-01 | 0.0875 |
9968 | MED12 | P2T-E | Human | Esophagus | ESCC | 1.07e-09 | 2.18e-01 | 0.1177 |
9968 | MED12 | P4T-E | Human | Esophagus | ESCC | 1.75e-05 | 1.15e-01 | 0.1323 |
9968 | MED12 | P5T-E | Human | Esophagus | ESCC | 3.98e-02 | 2.52e-02 | 0.1327 |
9968 | MED12 | P8T-E | Human | Esophagus | ESCC | 4.62e-14 | 2.51e-01 | 0.0889 |
9968 | MED12 | P9T-E | Human | Esophagus | ESCC | 2.30e-02 | 5.96e-02 | 0.1131 |
9968 | MED12 | P11T-E | Human | Esophagus | ESCC | 3.25e-05 | 1.73e-01 | 0.1426 |
9968 | MED12 | P12T-E | Human | Esophagus | ESCC | 9.52e-10 | 2.07e-01 | 0.1122 |
9968 | MED12 | P15T-E | Human | Esophagus | ESCC | 2.11e-03 | 7.07e-02 | 0.1149 |
9968 | MED12 | P16T-E | Human | Esophagus | ESCC | 2.04e-09 | 2.34e-01 | 0.1153 |
9968 | MED12 | P17T-E | Human | Esophagus | ESCC | 1.29e-08 | 2.65e-01 | 0.1278 |
9968 | MED12 | P21T-E | Human | Esophagus | ESCC | 5.07e-04 | 8.42e-02 | 0.1617 |
9968 | MED12 | P22T-E | Human | Esophagus | ESCC | 1.67e-17 | 1.79e-01 | 0.1236 |
9968 | MED12 | P23T-E | Human | Esophagus | ESCC | 1.99e-08 | 1.65e-01 | 0.108 |
9968 | MED12 | P24T-E | Human | Esophagus | ESCC | 1.71e-07 | 1.41e-01 | 0.1287 |
9968 | MED12 | P26T-E | Human | Esophagus | ESCC | 6.15e-08 | 2.02e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
GO:000184115 | Esophagus | ESCC | neural tube formation | 75/8552 | 102/18723 | 9.68e-09 | 1.95e-07 | 75 |
GO:000184314 | Esophagus | ESCC | neural tube closure | 66/8552 | 88/18723 | 1.98e-08 | 3.82e-07 | 66 |
GO:001402014 | Esophagus | ESCC | primary neural tube formation | 69/8552 | 94/18723 | 4.22e-08 | 7.76e-07 | 69 |
GO:006060614 | Esophagus | ESCC | tube closure | 66/8552 | 89/18723 | 4.24e-08 | 7.76e-07 | 66 |
GO:00219159 | Esophagus | ESCC | neural tube development | 101/8552 | 152/18723 | 1.78e-07 | 2.79e-06 | 101 |
GO:00163316 | Esophagus | ESCC | morphogenesis of embryonic epithelium | 98/8552 | 147/18723 | 2.12e-07 | 3.27e-06 | 98 |
GO:000183814 | Esophagus | ESCC | embryonic epithelial tube formation | 83/8552 | 121/18723 | 2.78e-07 | 4.08e-06 | 83 |
GO:009872714 | Esophagus | ESCC | maintenance of cell number | 90/8552 | 134/18723 | 3.94e-07 | 5.43e-06 | 90 |
GO:001982714 | Esophagus | ESCC | stem cell population maintenance | 88/8552 | 131/18723 | 5.23e-07 | 6.97e-06 | 88 |
GO:006007016 | Esophagus | ESCC | canonical Wnt signaling pathway | 180/8552 | 303/18723 | 9.15e-07 | 1.17e-05 | 180 |
GO:00063673 | Esophagus | ESCC | transcription initiation from RNA polymerase II promoter | 56/8552 | 77/18723 | 1.30e-06 | 1.59e-05 | 56 |
GO:003514815 | Esophagus | ESCC | tube formation | 96/8552 | 148/18723 | 1.86e-06 | 2.16e-05 | 96 |
GO:000635211 | Esophagus | ESCC | DNA-templated transcription, initiation | 86/8552 | 130/18723 | 1.88e-06 | 2.19e-05 | 86 |
GO:00721759 | Esophagus | ESCC | epithelial tube formation | 86/8552 | 132/18723 | 4.81e-06 | 5.10e-05 | 86 |
GO:006056210 | Esophagus | ESCC | epithelial tube morphogenesis | 187/8552 | 325/18723 | 9.95e-06 | 9.44e-05 | 187 |
GO:00074926 | Esophagus | ESCC | endoderm development | 54/8552 | 77/18723 | 1.20e-05 | 1.12e-04 | 54 |
GO:00017387 | Esophagus | ESCC | morphogenesis of a polarized epithelium | 63/8552 | 94/18723 | 2.34e-05 | 2.00e-04 | 63 |
GO:00420636 | Esophagus | ESCC | gliogenesis | 172/8552 | 301/18723 | 3.75e-05 | 3.04e-04 | 172 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0491928 | Esophagus | ESCC | Thyroid hormone signaling pathway | 78/4205 | 121/8465 | 6.79e-04 | 2.23e-03 | 1.14e-03 | 78 |
hsa04919113 | Esophagus | ESCC | Thyroid hormone signaling pathway | 78/4205 | 121/8465 | 6.79e-04 | 2.23e-03 | 1.14e-03 | 78 |
hsa0491912 | Liver | HCC | Thyroid hormone signaling pathway | 75/4020 | 121/8465 | 8.76e-04 | 3.38e-03 | 1.88e-03 | 75 |
hsa0491913 | Liver | HCC | Thyroid hormone signaling pathway | 75/4020 | 121/8465 | 8.76e-04 | 3.38e-03 | 1.88e-03 | 75 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MED12 | SNV | Missense_Mutation | c.2710N>C | p.Glu904Gln | p.E904Q | Q93074 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-CQ-5331-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MED12 | SNV | Missense_Mutation | novel | c.12N>G | p.Phe4Leu | p.F4L | Q93074 | protein_coding | tolerated(0.16) | benign(0.28) | TCGA-CQ-6221-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MED12 | SNV | Missense_Mutation | novel | c.5435N>G | p.Tyr1812Cys | p.Y1812C | Q93074 | protein_coding | tolerated_low_confidence(0.12) | probably_damaging(0.984) | TCGA-CR-6478-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | SD |
MED12 | SNV | Missense_Mutation | c.46N>G | p.Arg16Gly | p.R16G | Q93074 | protein_coding | deleterious(0) | possibly_damaging(0.597) | TCGA-CV-7248-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MED12 | SNV | Missense_Mutation | novel | c.3748C>T | p.Pro1250Ser | p.P1250S | Q93074 | protein_coding | tolerated(0.95) | benign(0) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MED12 | SNV | Missense_Mutation | novel | c.3749C>T | p.Pro1250Leu | p.P1250L | Q93074 | protein_coding | tolerated(0.36) | benign(0.003) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MED12 | SNV | Missense_Mutation | c.2303N>T | p.Arg768Leu | p.R768L | Q93074 | protein_coding | deleterious(0) | probably_damaging(0.928) | TCGA-F7-7848-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MED12 | SNV | Missense_Mutation | novel | c.4580N>G | p.Gln1527Arg | p.Q1527R | Q93074 | protein_coding | tolerated(0.06) | benign(0.007) | TCGA-F7-7848-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MED12 | SNV | Missense_Mutation | c.3605C>T | p.Ser1202Phe | p.S1202F | Q93074 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MED12 | SNV | Missense_Mutation | rs766598254 | c.2882N>A | p.Arg961Gln | p.R961Q | Q93074 | protein_coding | deleterious(0.01) | benign(0.42) | TCGA-IQ-7631-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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