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Gene: LRRIQ1 |
Gene summary for LRRIQ1 |
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Gene information | Species | Human | Gene symbol | LRRIQ1 | Gene ID | 84125 |
Gene name | leucine rich repeats and IQ motif containing 1 | |
Gene Alias | LRRIQ1 | |
Cytomap | 12q21.31 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | A0A140VJN5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84125 | LRRIQ1 | RNA-P6T1-P6T1-1 | Human | Lung | MIAC | 9.93e-08 | 1.04e+00 | -0.0238 |
84125 | LRRIQ1 | RNA-P6T1-P6T1-2 | Human | Lung | MIAC | 3.39e-12 | 1.21e+00 | -0.0186 |
84125 | LRRIQ1 | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 2.21e-10 | 1.22e+00 | -0.0296 |
84125 | LRRIQ1 | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 2.95e-10 | 1.04e+00 | -0.0263 |
84125 | LRRIQ1 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 1.74e-03 | 3.98e-01 | -0.0822 |
84125 | LRRIQ1 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 4.67e-04 | 3.88e-01 | -0.0809 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRRIQ1 | SNV | Missense_Mutation | novel | c.4943N>T | p.Arg1648Ile | p.R1648I | Q96JM4 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-CV-6951-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
LRRIQ1 | SNV | Missense_Mutation | novel | c.2108N>G | p.Ser703Cys | p.S703C | Q96JM4 | protein_coding | tolerated(0.08) | probably_damaging(0.956) | TCGA-CV-6961-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
LRRIQ1 | SNV | Missense_Mutation | novel | c.3866N>T | p.Arg1289Ile | p.R1289I | Q96JM4 | protein_coding | tolerated(0.09) | benign(0.289) | TCGA-CV-A45W-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
LRRIQ1 | SNV | Missense_Mutation | novel | c.2260N>A | p.Glu754Lys | p.E754K | Q96JM4 | protein_coding | tolerated(0.51) | benign(0.018) | TCGA-CV-A468-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LRRIQ1 | SNV | Missense_Mutation | rs778417753 | c.3336N>T | p.Leu1112Phe | p.L1112F | Q96JM4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CX-7086-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
LRRIQ1 | SNV | Missense_Mutation | novel | c.3946N>A | p.Glu1316Lys | p.E1316K | Q96JM4 | protein_coding | tolerated(0.07) | benign(0.067) | TCGA-D6-6516-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
LRRIQ1 | SNV | Missense_Mutation | c.163C>T | p.His55Tyr | p.H55Y | Q96JM4 | protein_coding | tolerated(0.28) | benign(0.005) | TCGA-KU-A6H7-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
LRRIQ1 | SNV | Missense_Mutation | novel | c.1429G>A | p.Asp477Asn | p.D477N | Q96JM4 | protein_coding | tolerated(0.08) | benign(0.107) | TCGA-TN-A7HL-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
LRRIQ1 | SNV | Missense_Mutation | novel | c.2191G>C | p.Glu731Gln | p.E731Q | Q96JM4 | protein_coding | tolerated(0.31) | benign(0.006) | TCGA-TN-A7HL-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
LRRIQ1 | SNV | Missense_Mutation | rs147514803 | c.3379G>A | p.Asp1127Asn | p.D1127N | Q96JM4 | protein_coding | tolerated(1) | benign(0) | TCGA-TN-A7HL-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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