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Gene: ZNF208 |
Gene summary for ZNF208 |
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Gene information | Species | Human | Gene symbol | ZNF208 | Gene ID | 7757 |
Gene name | zinc finger protein 208 | |
Gene Alias | PMIDP | |
Cytomap | 19p12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | M0QYK4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7757 | ZNF208 | HCC1 | Human | Liver | HCC | 2.90e-08 | 2.82e+00 | 0.5336 |
7757 | ZNF208 | HCC2 | Human | Liver | HCC | 2.94e-26 | 3.97e+00 | 0.5341 |
7757 | ZNF208 | male-WTA | Human | Thyroid | PTC | 2.12e-07 | 1.42e-01 | 0.1037 |
7757 | ZNF208 | PTC01 | Human | Thyroid | PTC | 2.09e-04 | 1.40e-01 | 0.1899 |
7757 | ZNF208 | PTC04 | Human | Thyroid | PTC | 1.04e-12 | 2.83e-01 | 0.1927 |
7757 | ZNF208 | PTC05 | Human | Thyroid | PTC | 6.87e-11 | 4.08e-01 | 0.2065 |
7757 | ZNF208 | PTC06 | Human | Thyroid | PTC | 2.67e-27 | 6.23e-01 | 0.2057 |
7757 | ZNF208 | PTC07 | Human | Thyroid | PTC | 1.67e-30 | 4.95e-01 | 0.2044 |
7757 | ZNF208 | ATC13 | Human | Thyroid | ATC | 9.45e-20 | 4.74e-01 | 0.34 |
7757 | ZNF208 | ATC5 | Human | Thyroid | ATC | 3.64e-23 | 5.14e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF208 | END | Thyroid | Healthy | HES5,MIR181A1HG,PIM2, etc. | 2.38e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF208 | SNV | Missense_Mutation | rs199604702 | c.2053G>A | p.Val685Ile | p.V685I | O43345 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-YL-A8SR-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
ZNF208 | SNV | Missense_Mutation | c.2582N>G | p.Tyr861Cys | p.Y861C | O43345 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ZNF208 | SNV | Missense_Mutation | novel | c.1392G>A | p.Met464Ile | p.M464I | O43345 | protein_coding | tolerated(0.44) | benign(0.041) | TCGA-BR-4369-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF208 | SNV | Missense_Mutation | c.2807A>T | p.Lys936Met | p.K936M | O43345 | protein_coding | tolerated(0.06) | probably_damaging(0.996) | TCGA-BR-6563-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | doxorubicin | CR | |
ZNF208 | SNV | Missense_Mutation | novel | c.2892N>T | p.Lys964Asn | p.K964N | O43345 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-BR-6802-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | CR |
ZNF208 | SNV | Missense_Mutation | novel | c.2883N>G | p.Ser961Arg | p.S961R | O43345 | protein_coding | tolerated(0.35) | benign(0.005) | TCGA-BR-7197-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF208 | SNV | Missense_Mutation | c.1715N>C | p.Lys572Thr | p.K572T | O43345 | protein_coding | deleterious(0.01) | probably_damaging(0.986) | TCGA-BR-7197-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF208 | SNV | Missense_Mutation | c.2455N>T | p.Thr819Ser | p.T819S | O43345 | protein_coding | tolerated(1) | benign(0.049) | TCGA-BR-8080-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ZNF208 | SNV | Missense_Mutation | c.2530N>G | p.Lys844Glu | p.K844E | O43345 | protein_coding | tolerated(0.24) | benign(0.264) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ZNF208 | SNV | Missense_Mutation | rs372427595 | c.659A>G | p.Lys220Arg | p.K220R | O43345 | protein_coding | tolerated(0.27) | probably_damaging(0.96) | TCGA-BR-8366-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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