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Gene: UTRN |
Gene summary for UTRN |
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Gene information | Species | Human | Gene symbol | UTRN | Gene ID | 7402 |
Gene name | utrophin | |
Gene Alias | DMDL | |
Cytomap | 6q24.2 | |
Gene Type | protein-coding | GO ID | GO:0001952 | UniProtAcc | P46939 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7402 | UTRN | CCI_1 | Human | Cervix | CC | 4.78e-04 | 9.71e-01 | 0.528 |
7402 | UTRN | CCI_3 | Human | Cervix | CC | 5.68e-08 | 7.88e-01 | 0.516 |
7402 | UTRN | L1 | Human | Cervix | CC | 3.10e-03 | -2.46e-01 | 0.0802 |
7402 | UTRN | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.66e-43 | -7.90e-01 | 0.0155 |
7402 | UTRN | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.88e-18 | -7.76e-01 | -0.1808 |
7402 | UTRN | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.95e-13 | -1.21e+00 | 0.0216 |
7402 | UTRN | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.84e-10 | -5.27e-01 | -0.0811 |
7402 | UTRN | HTA11_78_2000001011 | Human | Colorectum | AD | 2.50e-07 | -4.74e-01 | -0.1088 |
7402 | UTRN | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.37e-05 | -8.78e-01 | -0.2196 |
7402 | UTRN | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.98e-25 | -9.25e-01 | -0.1207 |
7402 | UTRN | HTA11_83_2000001011 | Human | Colorectum | SER | 5.06e-06 | -4.58e-01 | -0.1526 |
7402 | UTRN | HTA11_696_2000001011 | Human | Colorectum | AD | 3.21e-12 | -5.32e-01 | -0.1464 |
7402 | UTRN | HTA11_866_2000001011 | Human | Colorectum | AD | 7.70e-07 | -5.10e-01 | -0.1001 |
7402 | UTRN | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.08e-08 | -4.78e-01 | -0.059 |
7402 | UTRN | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.16e-05 | -6.89e-01 | -0.1706 |
7402 | UTRN | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.04e-15 | -9.73e-01 | -0.2061 |
7402 | UTRN | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.38e-04 | -6.89e-01 | -0.1462 |
7402 | UTRN | HTA11_546_2000001011 | Human | Colorectum | AD | 2.03e-04 | -4.64e-01 | -0.0842 |
7402 | UTRN | HTA11_9341_2000001011 | Human | Colorectum | SER | 2.47e-04 | -8.02e-01 | -0.00410000000000005 |
7402 | UTRN | HTA11_866_3004761011 | Human | Colorectum | AD | 3.30e-19 | -6.34e-01 | 0.096 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001081010 | Cervix | CC | regulation of cell-substrate adhesion | 69/2311 | 221/18723 | 8.57e-14 | 5.69e-11 | 69 |
GO:00315898 | Cervix | CC | cell-substrate adhesion | 96/2311 | 363/18723 | 1.48e-13 | 8.85e-11 | 96 |
GO:004578510 | Cervix | CC | positive regulation of cell adhesion | 101/2311 | 437/18723 | 1.96e-10 | 3.08e-08 | 101 |
GO:00019528 | Cervix | CC | regulation of cell-matrix adhesion | 40/2311 | 128/18723 | 1.32e-08 | 1.04e-06 | 40 |
GO:00071608 | Cervix | CC | cell-matrix adhesion | 60/2311 | 233/18723 | 1.58e-08 | 1.23e-06 | 60 |
GO:001081110 | Cervix | CC | positive regulation of cell-substrate adhesion | 34/2311 | 123/18723 | 3.66e-06 | 9.68e-05 | 34 |
GO:19023059 | Cervix | CC | regulation of sodium ion transmembrane transport | 19/2311 | 68/18723 | 4.21e-04 | 4.25e-03 | 19 |
GO:00020288 | Cervix | CC | regulation of sodium ion transport | 21/2311 | 90/18723 | 2.71e-03 | 1.85e-02 | 21 |
GO:00075173 | Cervix | CC | muscle organ development | 58/2311 | 327/18723 | 2.73e-03 | 1.85e-02 | 58 |
GO:00019548 | Cervix | CC | positive regulation of cell-matrix adhesion | 15/2311 | 58/18723 | 3.75e-03 | 2.38e-02 | 15 |
GO:20006498 | Cervix | CC | regulation of sodium ion transmembrane transporter activity | 15/2311 | 58/18723 | 3.75e-03 | 2.38e-02 | 15 |
GO:0010811 | Colorectum | AD | positive regulation of cell-substrate adhesion | 53/3918 | 123/18723 | 2.30e-08 | 1.27e-06 | 53 |
GO:0010810 | Colorectum | AD | regulation of cell-substrate adhesion | 81/3918 | 221/18723 | 4.80e-08 | 2.55e-06 | 81 |
GO:0031589 | Colorectum | AD | cell-substrate adhesion | 116/3918 | 363/18723 | 4.68e-07 | 1.76e-05 | 116 |
GO:0001952 | Colorectum | AD | regulation of cell-matrix adhesion | 50/3918 | 128/18723 | 2.05e-06 | 6.05e-05 | 50 |
GO:0001954 | Colorectum | AD | positive regulation of cell-matrix adhesion | 27/3918 | 58/18723 | 1.12e-05 | 2.55e-04 | 27 |
GO:0002028 | Colorectum | AD | regulation of sodium ion transport | 36/3918 | 90/18723 | 2.89e-05 | 5.37e-04 | 36 |
GO:0007160 | Colorectum | AD | cell-matrix adhesion | 75/3918 | 233/18723 | 3.56e-05 | 6.45e-04 | 75 |
GO:0045785 | Colorectum | AD | positive regulation of cell adhesion | 122/3918 | 437/18723 | 2.65e-04 | 3.28e-03 | 122 |
GO:1902305 | Colorectum | AD | regulation of sodium ion transmembrane transport | 27/3918 | 68/18723 | 3.19e-04 | 3.80e-03 | 27 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UTRN | SNV | Missense_Mutation | novel | c.10237G>C | p.Glu3413Gln | p.E3413Q | P46939 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-55-6968-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | unknown | PD |
UTRN | SNV | Missense_Mutation | c.3659G>A | p.Arg1220Lys | p.R1220K | P46939 | protein_coding | tolerated(0.08) | probably_damaging(0.994) | TCGA-55-6971-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UTRN | SNV | Missense_Mutation | c.5918G>T | p.Arg1973Met | p.R1973M | P46939 | protein_coding | deleterious(0.01) | possibly_damaging(0.73) | TCGA-55-8094-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
UTRN | SNV | Missense_Mutation | c.2036N>G | p.Lys679Arg | p.K679R | P46939 | protein_coding | tolerated(0.08) | benign(0.059) | TCGA-55-8097-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UTRN | SNV | Missense_Mutation | novel | c.3283N>T | p.Val1095Leu | p.V1095L | P46939 | protein_coding | tolerated(0.57) | benign(0.003) | TCGA-55-8299-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
UTRN | SNV | Missense_Mutation | c.6195N>T | p.Trp2065Cys | p.W2065C | P46939 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-64-1676-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
UTRN | SNV | Missense_Mutation | c.5797N>T | p.Asp1933Tyr | p.D1933Y | P46939 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-64-5779-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | PD | |
UTRN | SNV | Missense_Mutation | c.4426N>C | p.Asp1476His | p.D1476H | P46939 | protein_coding | deleterious(0.01) | possibly_damaging(0.633) | TCGA-69-7765-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | SD | |
UTRN | SNV | Missense_Mutation | c.1165G>C | p.Glu389Gln | p.E389Q | P46939 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-75-6214-01 | Lung | lung adenocarcinoma | Female | Unknown | III/IV | Unknown | Unknown | PD | |
UTRN | SNV | Missense_Mutation | c.7796A>G | p.Tyr2599Cys | p.Y2599C | P46939 | protein_coding | tolerated(0.12) | possibly_damaging(0.593) | TCGA-86-7711-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7402 | UTRN | NA | ENZYME INHIBITOR | 15639474 | ||
7402 | UTRN | NA | SMT-C1100 | EZUTROMID |
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