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Gene: FLNC |
Gene summary for FLNC |
Gene summary. |
Gene information | Species | Human | Gene symbol | FLNC | Gene ID | 2318 |
Gene name | filamin C | |
Gene Alias | ABP-280 | |
Cytomap | 7q32.1 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q14315 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2318 | FLNC | HCC1_Meng | Human | Liver | HCC | 2.19e-44 | 2.51e-01 | 0.0246 |
2318 | FLNC | HCC2 | Human | Liver | HCC | 9.56e-45 | 5.24e+00 | 0.5341 |
2318 | FLNC | Pt13.b | Human | Liver | HCC | 6.02e-08 | 1.62e-01 | 0.0251 |
2318 | FLNC | S014 | Human | Liver | HCC | 3.64e-16 | 6.36e-01 | 0.2254 |
2318 | FLNC | S015 | Human | Liver | HCC | 1.83e-15 | 7.18e-01 | 0.2375 |
2318 | FLNC | S016 | Human | Liver | HCC | 2.97e-13 | 4.28e-01 | 0.2243 |
2318 | FLNC | ATC09 | Human | Thyroid | ATC | 2.66e-04 | 2.53e-01 | 0.2871 |
2318 | FLNC | ATC11 | Human | Thyroid | ATC | 5.90e-10 | 6.87e-01 | 0.3386 |
2318 | FLNC | ATC12 | Human | Thyroid | ATC | 1.15e-03 | 1.27e-01 | 0.34 |
2318 | FLNC | ATC13 | Human | Thyroid | ATC | 1.12e-33 | 6.27e-01 | 0.34 |
2318 | FLNC | ATC1 | Human | Thyroid | ATC | 4.95e-05 | 2.79e-01 | 0.2878 |
2318 | FLNC | ATC2 | Human | Thyroid | ATC | 1.60e-07 | 9.26e-01 | 0.34 |
2318 | FLNC | ATC3 | Human | Thyroid | ATC | 3.69e-12 | 5.60e-01 | 0.338 |
2318 | FLNC | ATC4 | Human | Thyroid | ATC | 2.34e-04 | 1.52e-01 | 0.34 |
2318 | FLNC | ATC5 | Human | Thyroid | ATC | 8.04e-38 | 6.72e-01 | 0.34 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004269216 | Thyroid | ATC | muscle cell differentiation | 165/6293 | 384/18723 | 7.17e-05 | 5.46e-04 | 165 |
GO:005500112 | Thyroid | ATC | muscle cell development | 81/6293 | 184/18723 | 2.02e-03 | 9.60e-03 | 81 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513242 | Liver | HCC | Salmonella infection | 178/4020 | 249/8465 | 5.90e-15 | 1.98e-13 | 1.10e-13 | 178 |
hsa0451041 | Liver | HCC | Focal adhesion | 125/4020 | 203/8465 | 3.12e-05 | 1.88e-04 | 1.04e-04 | 125 |
hsa0520521 | Liver | HCC | Proteoglycans in cancer | 121/4020 | 205/8465 | 5.22e-04 | 2.18e-03 | 1.21e-03 | 121 |
hsa0513252 | Liver | HCC | Salmonella infection | 178/4020 | 249/8465 | 5.90e-15 | 1.98e-13 | 1.10e-13 | 178 |
hsa0451051 | Liver | HCC | Focal adhesion | 125/4020 | 203/8465 | 3.12e-05 | 1.88e-04 | 1.04e-04 | 125 |
hsa0520531 | Liver | HCC | Proteoglycans in cancer | 121/4020 | 205/8465 | 5.22e-04 | 2.18e-03 | 1.21e-03 | 121 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FLNC | SNV | Missense_Mutation | c.1709G>C | p.Gly570Ala | p.G570A | Q14315 | protein_coding | deleterious(0) | possibly_damaging(0.902) | TCGA-21-5782-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FLNC | SNV | Missense_Mutation | rs200415625 | c.5954N>T | p.Ser1985Leu | p.S1985L | Q14315 | protein_coding | deleterious(0.02) | probably_damaging(0.991) | TCGA-21-5787-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
FLNC | SNV | Missense_Mutation | c.3529N>T | p.Thr1177Ser | p.T1177S | Q14315 | protein_coding | tolerated(0.49) | benign(0.06) | TCGA-22-1002-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FLNC | SNV | Missense_Mutation | novel | c.1366N>A | p.Gly456Ser | p.G456S | Q14315 | protein_coding | deleterious(0.01) | probably_damaging(0.933) | TCGA-33-AAS8-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FLNC | SNV | Missense_Mutation | c.7483N>A | p.Arg2495Ser | p.R2495S | Q14315 | protein_coding | deleterious(0.04) | possibly_damaging(0.777) | TCGA-34-5927-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
FLNC | SNV | Missense_Mutation | c.838G>T | p.Ala280Ser | p.A280S | Q14315 | protein_coding | deleterious(0.02) | probably_damaging(0.993) | TCGA-39-5027-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
FLNC | SNV | Missense_Mutation | c.5025N>T | p.Glu1675Asp | p.E1675D | Q14315 | protein_coding | tolerated(0.06) | benign(0.034) | TCGA-39-5031-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FLNC | SNV | Missense_Mutation | novel | c.5744N>A | p.Thr1915Asn | p.T1915N | Q14315 | protein_coding | deleterious(0.03) | benign(0.34) | TCGA-39-5040-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | PD |
FLNC | SNV | Missense_Mutation | c.4783G>T | p.Asp1595Tyr | p.D1595Y | Q14315 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-43-5668-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Other, specify in notesMAGE3-AS15-NSC-003 | clinical | PD | |
FLNC | SNV | Missense_Mutation | novel | c.5012N>T | p.Lys1671Met | p.K1671M | Q14315 | protein_coding | deleterious(0.02) | probably_damaging(0.986) | TCGA-43-8118-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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