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Gene: FLNB |
Gene summary for FLNB |
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Gene information | Species | Human | Gene symbol | FLNB | Gene ID | 2317 |
Gene name | filamin B | |
Gene Alias | ABP-278 | |
Cytomap | 3p14.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | O75369 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2317 | FLNB | GSM4909281 | Human | Breast | IDC | 2.52e-14 | 4.93e-01 | 0.21 |
2317 | FLNB | GSM4909296 | Human | Breast | IDC | 5.82e-03 | -1.20e-01 | 0.1524 |
2317 | FLNB | GSM4909297 | Human | Breast | IDC | 2.00e-02 | -9.20e-02 | 0.1517 |
2317 | FLNB | GSM4909298 | Human | Breast | IDC | 1.72e-09 | 3.35e-01 | 0.1551 |
2317 | FLNB | GSM4909301 | Human | Breast | IDC | 2.85e-27 | 7.38e-01 | 0.1577 |
2317 | FLNB | GSM4909304 | Human | Breast | IDC | 1.03e-14 | 5.06e-01 | 0.1636 |
2317 | FLNB | GSM4909311 | Human | Breast | IDC | 1.84e-19 | 1.27e-01 | 0.1534 |
2317 | FLNB | GSM4909312 | Human | Breast | IDC | 4.41e-02 | -1.42e-02 | 0.1552 |
2317 | FLNB | GSM4909319 | Human | Breast | IDC | 7.46e-16 | -7.51e-02 | 0.1563 |
2317 | FLNB | GSM4909320 | Human | Breast | IDC | 1.37e-06 | 3.32e-01 | 0.1575 |
2317 | FLNB | GSM4909321 | Human | Breast | IDC | 1.33e-09 | 1.60e-01 | 0.1559 |
2317 | FLNB | brca3 | Human | Breast | Precancer | 3.75e-04 | 2.39e-01 | -0.0263 |
2317 | FLNB | M1 | Human | Breast | IDC | 1.27e-14 | 6.30e-01 | 0.1577 |
2317 | FLNB | NCCBC14 | Human | Breast | DCIS | 1.09e-05 | -7.28e-02 | 0.2021 |
2317 | FLNB | NCCBC2 | Human | Breast | DCIS | 7.91e-12 | 6.93e-01 | 0.1554 |
2317 | FLNB | NCCBC5 | Human | Breast | DCIS | 3.00e-06 | -1.09e-01 | 0.2046 |
2317 | FLNB | P1 | Human | Breast | IDC | 3.17e-08 | 1.52e-01 | 0.1527 |
2317 | FLNB | P3 | Human | Breast | IDC | 1.00e-09 | 8.24e-01 | 0.1542 |
2317 | FLNB | DCIS2 | Human | Breast | DCIS | 1.69e-40 | 6.47e-02 | 0.0085 |
2317 | FLNB | CCI_1 | Human | Cervix | CC | 4.47e-12 | 1.38e+00 | 0.528 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00085445 | Breast | Precancer | epidermis development | 35/1080 | 324/18723 | 2.71e-04 | 3.96e-03 | 35 |
GO:00099136 | Breast | Precancer | epidermal cell differentiation | 23/1080 | 202/18723 | 1.43e-03 | 1.50e-02 | 23 |
GO:00302163 | Breast | Precancer | keratinocyte differentiation | 17/1080 | 139/18723 | 2.71e-03 | 2.39e-02 | 17 |
GO:00605374 | Breast | Precancer | muscle tissue development | 37/1080 | 403/18723 | 3.60e-03 | 2.98e-02 | 37 |
GO:00020649 | Breast | Precancer | epithelial cell development | 23/1080 | 220/18723 | 4.28e-03 | 3.35e-02 | 23 |
GO:00147063 | Breast | Precancer | striated muscle tissue development | 35/1080 | 384/18723 | 5.10e-03 | 3.83e-02 | 35 |
GO:006053711 | Breast | IDC | muscle tissue development | 50/1434 | 403/18723 | 4.91e-04 | 6.45e-03 | 50 |
GO:000854412 | Breast | IDC | epidermis development | 41/1434 | 324/18723 | 1.03e-03 | 1.14e-02 | 41 |
GO:000991312 | Breast | IDC | epidermal cell differentiation | 28/1434 | 202/18723 | 1.62e-03 | 1.60e-02 | 28 |
GO:00147061 | Breast | IDC | striated muscle tissue development | 46/1434 | 384/18723 | 1.67e-03 | 1.63e-02 | 46 |
GO:00302161 | Breast | IDC | keratinocyte differentiation | 21/1434 | 139/18723 | 2.06e-03 | 1.95e-02 | 21 |
GO:00343414 | Breast | IDC | response to interferon-gamma | 21/1434 | 141/18723 | 2.46e-03 | 2.22e-02 | 21 |
GO:00435883 | Breast | IDC | skin development | 33/1434 | 263/18723 | 3.46e-03 | 2.87e-02 | 33 |
GO:000206414 | Breast | IDC | epithelial cell development | 28/1434 | 220/18723 | 5.53e-03 | 4.05e-02 | 28 |
GO:00075172 | Breast | IDC | muscle organ development | 38/1434 | 327/18723 | 6.63e-03 | 4.62e-02 | 38 |
GO:006053721 | Breast | DCIS | muscle tissue development | 50/1390 | 403/18723 | 2.39e-04 | 3.74e-03 | 50 |
GO:00147062 | Breast | DCIS | striated muscle tissue development | 46/1390 | 384/18723 | 8.88e-04 | 1.01e-02 | 46 |
GO:000854422 | Breast | DCIS | epidermis development | 40/1390 | 324/18723 | 1.05e-03 | 1.16e-02 | 40 |
GO:000991322 | Breast | DCIS | epidermal cell differentiation | 27/1390 | 202/18723 | 2.11e-03 | 1.97e-02 | 27 |
GO:00302162 | Breast | DCIS | keratinocyte differentiation | 20/1390 | 139/18723 | 3.24e-03 | 2.74e-02 | 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513218 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0520514 | Breast | Precancer | Proteoglycans in cancer | 30/684 | 205/8465 | 1.00e-03 | 7.18e-03 | 5.50e-03 | 30 |
hsa0513219 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0520515 | Breast | Precancer | Proteoglycans in cancer | 30/684 | 205/8465 | 1.00e-03 | 7.18e-03 | 5.50e-03 | 30 |
hsa0513224 | Breast | IDC | Salmonella infection | 55/867 | 249/8465 | 2.07e-08 | 4.49e-07 | 3.36e-07 | 55 |
hsa0520523 | Breast | IDC | Proteoglycans in cancer | 42/867 | 205/8465 | 7.69e-06 | 9.99e-05 | 7.48e-05 | 42 |
hsa045109 | Breast | IDC | Focal adhesion | 32/867 | 203/8465 | 8.60e-03 | 4.23e-02 | 3.17e-02 | 32 |
hsa0513234 | Breast | IDC | Salmonella infection | 55/867 | 249/8465 | 2.07e-08 | 4.49e-07 | 3.36e-07 | 55 |
hsa0520533 | Breast | IDC | Proteoglycans in cancer | 42/867 | 205/8465 | 7.69e-06 | 9.99e-05 | 7.48e-05 | 42 |
hsa0451013 | Breast | IDC | Focal adhesion | 32/867 | 203/8465 | 8.60e-03 | 4.23e-02 | 3.17e-02 | 32 |
hsa0513243 | Breast | DCIS | Salmonella infection | 55/846 | 249/8465 | 8.71e-09 | 1.87e-07 | 1.38e-07 | 55 |
hsa0520542 | Breast | DCIS | Proteoglycans in cancer | 39/846 | 205/8465 | 5.36e-05 | 5.58e-04 | 4.11e-04 | 39 |
hsa0513253 | Breast | DCIS | Salmonella infection | 55/846 | 249/8465 | 8.71e-09 | 1.87e-07 | 1.38e-07 | 55 |
hsa0520552 | Breast | DCIS | Proteoglycans in cancer | 39/846 | 205/8465 | 5.36e-05 | 5.58e-04 | 4.11e-04 | 39 |
hsa0513220 | Cervix | CC | Salmonella infection | 74/1267 | 249/8465 | 1.33e-09 | 2.54e-08 | 1.50e-08 | 74 |
hsa0520516 | Cervix | CC | Proteoglycans in cancer | 60/1267 | 205/8465 | 9.13e-08 | 1.18e-06 | 7.00e-07 | 60 |
hsa0451010 | Cervix | CC | Focal adhesion | 59/1267 | 203/8465 | 1.53e-07 | 1.84e-06 | 1.09e-06 | 59 |
hsa040109 | Cervix | CC | MAPK signaling pathway | 62/1267 | 302/8465 | 4.89e-03 | 1.67e-02 | 9.86e-03 | 62 |
hsa05132110 | Cervix | CC | Salmonella infection | 74/1267 | 249/8465 | 1.33e-09 | 2.54e-08 | 1.50e-08 | 74 |
hsa0520517 | Cervix | CC | Proteoglycans in cancer | 60/1267 | 205/8465 | 9.13e-08 | 1.18e-06 | 7.00e-07 | 60 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FLNB | insertion | Frame_Shift_Ins | novel | c.4523_4524insCA | p.Val1512GlnfsTer2 | p.V1512Qfs*2 | O75369 | protein_coding | TCGA-HJ-7597-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | CR | ||
FLNB | insertion | Frame_Shift_Ins | novel | c.731_732insG | p.Ala246GlyfsTer49 | p.A246Gfs*49 | O75369 | protein_coding | TCGA-HU-A4GX-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | SD | ||
FLNB | insertion | Frame_Shift_Ins | rs746105983 | c.1585_1586insG | p.His532ThrfsTer9 | p.H532Tfs*9 | O75369 | protein_coding | TCGA-HU-A4H3-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | ts-1 | PD | ||
FLNB | SNV | Missense_Mutation | c.1892N>A | p.Pro631Gln | p.P631Q | O75369 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-DJ-A2PX-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FLNB | SNV | Missense_Mutation | rs754457328 | c.7036G>A | p.Ala2346Thr | p.A2346T | O75369 | protein_coding | deleterious(0.02) | probably_damaging(0.983) | TCGA-KS-A4IB-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Hormone Therapy | cytomel | CR |
FLNB | insertion | Frame_Shift_Ins | novel | c.2390_2391insGGGGAAAGGGATGA | p.Phe797LeufsTer57 | p.F797Lfs*57 | O75369 | protein_coding | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
FLNB | insertion | Frame_Shift_Ins | novel | c.2390_2391insGGGGAAAGGGA | p.Phe797LeufsTer56 | p.F797Lfs*56 | O75369 | protein_coding | TCGA-EL-A3ZR-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
FLNB | insertion | Frame_Shift_Ins | novel | c.1724_1725insAGCTACTGTTATGTCAACAATA | p.Gly576AlafsTer10 | p.G576Afs*10 | O75369 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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